[Diagnosis and therapy of bone metastases].
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Biopsy↗
Biomedical subjects
H E Schratt
Publications and source records attributed to H E Schratt.
[Diagnosis and therapy of bone metastases].
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Biopsy↗
Foot fractures in restrained front seat car occupants: a long-term study over twenty-three years.
OBJECTIVES: To analyze the mechanism of injury for foot and ankle fractures resulting from automobile accidents to create a basis for developing an improved design for protection. DESIGN: Retrospective. SETTING: Level I trauma center with accident research unit. PATIENTS: Automobile accident reports and medical records of individuals injured in the accidents. MAIN OUTCOME MEASUREMENTS: Technical indicators (collision type, impulse angle, deltav, and extent of vehicle deformation) and clinical data (injury location and severity [abbreviated injury scale and injury severity score] and long-term outcome). RESULTS: From 1973 to 1996, 15,559 car accidents were analyzed. Two hundred sixty-one front seat occupants sustained fractures of the foot and ankle (ankle, 41 percent; forefoot, 29 percent; midfoot, 20 percent; and hindfoot, 10 percent). Seventy-five percent of the fractures were classified abbreviated injury scale(foot) 2. The incidence, location, and abbreviated injury scale(foot) category of fractures were similar between driver (n = 210) and front seat passenger (n = 51). Fifty percent of the fractures occurred in head-on collisions and 34 percent occurred in accidents with multiple collisions. The deltav ranged in 82 percent of car crashes between fifteen and sixty kilometers per hour. The deltav and extent of foot compartment deformation correlated with the abbreviated injury scale. During our investigation, deltav increased; the injury severity score decreased; and the extent of deformation did not differ significantly. CONCLUSIONS: Although overall car passenger safety has improved, the relative incidence of foot and ankle fractures has increased. Comparing drivers and front seat passengers, the foot pedals, steering wheel, or the asymmetric design of the dashboard did not influence injury incidence, mechanism, or severity. Foot fractures are mainly caused by the foot compartment deformation in head-on collisions, and therefore improvements in foot compartments are essential for fracture prevention.
Abbreviated Injury Scale↗
Fractures and fracture dislocations of the midfoot: occurrence, causes and long-term results.
Etiology and outcome of 155 patients with midfoot fractures between 1972 and 1997 were analyzed to create a basis for treatment optimization. Cause of injuries were traffic accidents (72.2%), falls (11.6%), blunt injuries (7.7%) and others (5.8%). Isolated midfoot fractures (I) were found in 55 (35.5%) cases, Lisfranc fracture dislocations (L) in 49 (31.2%), Chopart-Lisfranc fracture dislocations (CL) in 26 (16.8%) and Chopart fracture dislocations (C) in 25 (16%). One hundred and forty eight (95%) of the midfoot fractures were treated operatively; 30 with closed reduction, 115 with open reduction, 3 patients had a primary amputation. Seven (5%) patients were treated non-operatively. Ninety seven (63%) patients had follow-up at an average of 9 (1.3-25, median 8.5) years. The average scores of the entire follow-up group were as follows: AOFAS - sum of all four sections (AOFAS-ET): 296, AOFAS-Midfoot (AOFAS-M): 71, Hannover Scoring System (HSS): 65, and Hannover Questionnaire (Q): 63. Regarding age, gender, cause, time from injury to treatment and method of treatment no score differences were noted (t-test: p>0.05). L, C or I showed similar scores and CL significantly lower scores (AOFAS-ET, AOFAS-M, HSS, Q). The highest scores in all groups were achieved in those fractures treated with early open reduction and operative fixation. Midfoot fractures, particularly fracture dislocation injuries, effect the function of the entire foot in the long-term outcome. But even in these complex injuries, an early anatomic (open) reduction and stable (internal) fixation can minimize the percentage of long-term impairment.
Adolescent↗
[Healing of autologous cancellous bone transplants and hydroxylapatite ceramics in tibial segment defects. Value of ultrasonic follow up].
The aim of this study was to develop and test a scoring system based on real-time ultrasonography (US), which is able to predict the healing of a bone defect filled with a bone graft substitute or cancellous bone graft. We implanted porous hydroxy-apatite (HA) ceramic blocks into a segmental defect in the tibia of 51 sheep; 14 sheep received autologous bone graft from the iliac crest. Follow-up times were 3, 6 and 12 months. With the exception of the 12-month animals, there was a minimum of 6 animals in each group. At the end of follow-up the tibiae were tested in torsion to failure. These results were correlated with radiographic and ultrasound scores measured on the same specimens. With the scoring system it was possible to describe the osseous integration of the HA ceramic or mineralisation of the cancellous bone graft. Sheep with ceramic implant that developed non-unions showed a significantly lower score than sheep with a sufficient implant integration. A significant correlation between these scores and the biomechanical results was found. We were able to define a cut-off within the scoring system which made the prediction of instability/non-union possible. In our model we were able to predict the osseous integration of HA ceramics and autologous cancellous bone grafts with the use of real-time ultrasound.
Animals↗
[Subtalar fusion after conservative or surgical treatment of calcaneus fracture. A comparison of long-term results].
In a long-term follow-up we evaluated 40 patients out of 55 (73%) with a subtalar fusion. The operations took place from 5/84 to 5/91. In all cases the indication for the fusion was a post-traumatic arthritis after an intra-articular os calcis fracture. The evaluation of the overall results was carried out with three different scoring systems: a. The Hannover Scoring System. b. The Outcome-questionnaire, rating patient's complaints and the functional status based on the severity-symptom scale and functional status described for Carpaltunnel-syndrome by Levine et al. c. The clinical rating system (CRS) described by Kitaoka et al. The statistical evaluation was performed by analysis of variance (ANOVA). Level of significance was based on P = 0.05 and calculation of Pearson's correlation coefficient. The Os calcis fracture was the cause for the subtalar arthritis in all 40 patients (33 males and 7 females). The primary treatment of the calcaneal fracture was conservative (cons.) using a plaster in 23 patients (57.5%), while 17 patients (42.5%) underwent open reduction and plate fixation (op.). The interval between trauma and subtalar fusion averaged 3.5 years (3 months to 20 years). The interval between subtalar fusion and follow-up averaged 5.2 years (4-14 years). The mean age at the time of reexamination was 47 years (26-61 years). In the present study, complete pain relief could be achieved in 21 (52.5%; 58% op., 50% cons.) patients. A relevant restriction in the range of motion in the ankle joint was found in 26 (65%; 76% op., 58% cons.). In 23 patients (62%; 65% op., 59% cons.) the radiological evaluation revealed a grade 1 degree arthritis of the ankle joint, in the talonavicular joint in 17 patients (42.5%; 41% op., 45% cons.), and in the calcaneo-cuboid joint in 14 patients (35%; 47%., 27% cons.). The statistical analysis revealed a better outcome in the operative group compared with the conservative group, although the operated os calcis fractures in the majority were the more severe fracture types. In all evaluation systems a score between 61 and 69 points could be achieved with no significant difference between the operatively and conservatively treated groups and between the newly developed questionaire and the clinical-radiological scoring systems. For the questionaire this fulfills the requirements for a reliable outcome evaluation.
Adult↗
[Treatment of intraarticular calcaneal fractures in adults. A treatment algorithm].
Significant progress has been made in terms of the management of calcaneal fractures. This is reflected in the marked decrease in complication rates associated with the current intervention of these potentially devastating injuries. The treatment priorities that, in the authors opinion, are key to achieve best results in a displaced calcaneal fracture are anatomic reconstruction of the entire calcaneus: articular surfaces, height, alignment, and length, with a function directed postoperative management. The value of these priorities are confirmed by the authors longterm follow-up results as presented here. To reemphasize, conservative treatment should be considered only in cases of extraarticular fractures, minor displaced intraarticular fractures in nonambulatory patients, and in cases where there is a clear contraindication for surgery. Regarding the technical requirements for an anatomic reconstruction, the os calcis fracture should be categorized as a procedure for experts. In two-part fractures, according to the Sanders classification, an anatomical reduction is obtainable in more than 80%-90% of cases. However, in consideration of the articular cartilage damage, a 70% rate of good to excellent clinical results seems realistic. In three-part fractures, anatomic reduction is attainable in about 60% of cases with a 70% rate of good results. These two subgroups comprise about 90% of all calcaneus fractures. It is the authors recent experience to optimize the extended lateral approach using posteromedial and anterolateral windows, so that an anatomic reduction in more than 60% of Sanders Type III os calcis fractures can be achieved. Further scientific work in this area of trauma orthopedics would benefit most from a general consensus on a fracture classification system and on a clinical scoring system, with 5 year follow-up studies using these treatment methods and evaluation systems.
Adult↗
The influence of hydroxyapatite granules on the healing of a segmental defect filled with autologous bone marrow.
Hydroxyapatite(HA) ceramics are frequently used as a bone graft substitutes for the filling of bony defects. The addition of autologous bone marrow to HA ceramics does improve defect healing. There is conflicting evidence in the literature whether autologous bone marrow transplantation alone is as effective as the combination of HA ceramics and bone marrow combined. It was the purpose of this study to identify the role of additional HA ceramic granules on the healing of a sheep tibia segmental defect filled with autologous bone marrow. After permission of the local animal rights committee was obtained, a 3 cm segmental defect in the midshaft of 31 adult sheep was stabilized with an unreamed tibia nail. The animals were divided into 4 groups according to the mode of defect filling: HA plus autologous bone marrow (HA + MAR) (n = 8), autologous bone marrow (MAR) (n = 9), empty defect (DEF) (n = 6), cancellous bone graft (CAN) (n = 8). After three months follow up animals were sacrificed and analysed for the key parameters of union and maximum torque at failure. One nonunion was present in each of the HA + MAR, MAR, and CAN groups. Four of the six animals in the DEF group developed a nonunion. Maximum torque at failure was reported as percentage of the intact contralateral tibia: HA + MAR 39% +/- 24%, MAR 26% +/- 17%, DEF 22% +/- 13%, CAN 41% +/- 20%. The difference between the groups was statistically significant, but appeared to be relevant. We conclude from our data, that HA ceramics do improve healing of a segmental defect in the sheep tibia filled with autologous bone marrow. The results of this combination are comparable to cancellous autograft.
Animals↗
[Fractures of the pediatric foot].
Some 13% of fractures in children are in the foot. Of these fractures, 50% involve the metatarsals and the phalanges. These are treated conservatively and do not cause therapeutic problems in general. In contrast, fractures and dislocations of the midfoot and hindfoot occur very rarely, so profound therapeutic expertise is lacking. The present paper takes stock and provides a critical assessment of the therapeutic concepts presented hitherto and new approaches to different problematic fractures. The long-term results of the literature and our own follow-up of dislocated intraarticular talus and calcaneus fractures which were not reduced anatomically has shown important problems in terms of pain, limited range of motion and malalignment in adolescence. In contrast to the findings in adults, no arthrosis was apparent in the radiological examinations. The findings were similar in mishealed Chopart dislocation and Lisfranc dislocation. The treatment of complex foot trauma is a multidisciplinary team approach. These challenging injuries should be treated only in centers where vascular and plastic surgeons are constantly available. The precise scientific assessment of foot fractures in children is confronted with the problem that so far too few cases have been evaluated. Rare problematic fractures (i.e. talus, calcaneus) require scientific work-up to establish a "gold standard" for operative and conservative treatment. This can only be accomplished in a multicenter study.
Adolescent↗
Management of calcaneal fractures in adults. Conservative versus operative treatment.
Significant progress had been made in the management of calcaneal fractures. This is reflected in the marked decrease in complication rates associated with the current intervention of these potentially devastating injuries. The treatment priorities that are key to achieve best results in a displaced calcaneal fracture are an anatomic reconstruction of the entire calcaneus including articular surfaces, height, alignment, and length, with a function directed postoperative management. The value of these priorities is confirmed by long term followup results. Conservative treatment should be considered only in cases of extraarticular fractures, in cases of minor displaced intraarticular fractures in patients who are nonambulatory, and in cases where there is a clear contraindication for surgery. An anatomic reconstruction of an os calcis fracture is difficult to obtain. In two-part fractures, according to the classification described by Sanders et al, an anatomic reduction is obtainable in more than 80% of cases. However, if the articular cartilage damage that is typically present is considered, a 70% rate of good to excellent clinical results is more realistic. In three-part fractures, anatomic reduction is attainable in approximately 60% of cases with a 70% rate of good results. These two subgroups comprise approximately 90% of all calcaneal fractures. It has been put into practice recently to optimize the extended lateral approach using posteromedial and anterolateral windows, so that an anatomic reduction can be achieved in more than 60% of os calcis fractures considered as Type III according to the classification described by Sanders et al. Additional scientific work in this area of trauma orthopaedics would benefit most from a general consensus on a fracture classification system and on a clinical scoring system, with 5-year followup studies using these treatment methods and evaluation systems.
Algorithms↗
[Experimental studies of healing and antigenicity of sterilized bone transplants].
UNLABELLED: The aim of our study was to observe the incorporation and induced immune response of sterilized bone allografts. We performed an orthotopical tibial segment transplantation using two different inbred rat strains. We compared irradiated (25 kGy), autoclaved (134 degrees C) and cryopreserved (-80 degrees C) bone grafts. The observation took place 6 and 12 weeks post-operatively. RESULTS: The incorporation of irradiated grafts took longer than cryopreserved transplants. Autoclaved grafts were not incorporated and only bridged by new callus formation. A cell-mediated immune response against the cryopreserved grafts could be demonstrated. Irradiated grafts induced a major immune response; autoclaved grafts did not. CONCLUSION: There seems to be a correlation between loss of antigenicity and failure of graft incorporation. Therefore, it seems probable, that some bone antigenicity is necessary for the induction of cellular mechanisms during graft incorporation.
Animals↗
[Complications of spongiosa harvesting of the ilial crest. A retrospective analysis of 1,191 cases].
We analyzed retrospectively 1191 cases of bone graft harvesting of the iliac crest which had been performed at our hospital between 1982 and 1991. There was an operative revision rate of 2.8%. For further study, we analyzed the clinical reports of all autograft (iliac crest) donors in a representative year (1991) and re-examined all those who still had symptoms. A total of 104 grafts were taken from 97 patients. Of these, 18 developed postoperative complications (19.6%), such as hematoma, which could usually be treated with local procedures such as aspiration. The rate of hematoma tended to be lower in those patients who had received a local coagulant, but this was not significant. Of the patients 55% still had problems 1 year after operation at the time of re-examination, but in most cases they were minor, for example, local irritation or discomfort. Serious problems developed in those patients who had a palpable defect of the iliac crest. We advise using local coagulants to decrease the rate of postoperative complications, although we cannot statistically prove the effect. When large grafts are harvested, the iliac crest should be reconstructed for better long-term results.
Adolescent↗
[Malignant bone tumors].
Owing to advances in adjuvant therapy, the outlook for patients with primary malignant bone tumors has improved dramatically in recent decades. This applies both to improved survival and to increased limb salvage rates. The diagnostic strategies and a staging system for malignant bone tumors are outlined. Technical aspects of the standard limb salvage procedures, such as Tikhoff-Linberg resection at the shoulder, internal hemipelvectomy, proximal and distal femur resection and rotation plasty are presented. The use of soft tissue procedures such as flaps and the use of modular implant systems has reduced the complication rates of limb salvage procedures. In the future we hope to further improve prognosis and quality of life for such patients by the application of risk-adapted strategies for chemotherapy and surgery.
Adolescent↗
[HIV infection caused by cold preserved bone transplants].
We reporting four cases of HIV infection caused by bone allografts from one donor. All transplantations were performed between November 1984 and January 1985. In all, 12 recipients had bone allografts from the HIV-infected donor, 7 of whom are now HIV-negative and 4, HIV-positive. One of the patients died a natural death in her 10th decade. The donor was not been tested before the grafts were harvested, as HIV-antibody detection was not possible at the time (October 1984); no HIV-antibody kits had yet been developed. Subsequent testing of the asservated serum for HIV antibodies gave a positive result. The chronological course of the case is described and the case is discussed in detail.
Adolescent↗
[Organization of a bone and tissue bank. Consequences for organization of bone and tissue banks after HIV and hepatitis C infections].
The use of non-treated cryopreserved bone allografts has been criticized following the publication of new cases of HIV and hepatitis-C infection caused by such grafts. However, the "new" cases of HIV infection arose in 1984/1985. when HIV testing was not possible. A critical analysis of the German bone bank procedures shows that the official guidelines are not adequate. Furthermore, new sterilization techniques are propagated for clinical use. This leads to a false feeling of security, and does not help to solve the problem of virus transmission by way of bone allografts. It is therefore essential that new guidelines for bone bank management be developed as a matter of urgency, with due consideration for everything known about this problem to date. Our current bone bank procedure is presented and the various points in the official guidelines that need updating are discussed, including the necessity for 6-month HIV and hepatitis testing modified donor screening, and special guidelines for multiple organ donors.
Bone Banks↗
[Intestinal cytokine liberation after intestinal ischemia in the rat--studies in the Ussing chamber system].
UNLABELLED: Intestinal ischemia, frequently found in clinical states such as aortic bypass operations or hemorrhagic shock, is associated with loss of gut barrier function. Subsequent translocation of indigenous bacteria and endotoxin have been implicated as a major contributor to a systemic immuno-inflammatory response, which finally leads to multiple organ failure. There is increasing evidence that intestinal injury can result in the gut becoming a cytokine generating organ. This study was designed to show direct evidence of the gut as a major source of proinflammatory cytokines after intestinal ischemia and to further relate this cytokine response to the extent of intestinal ischemia/reperfusion. Additionally the potential role of the altered intestinal barrier function after intestinal ischemia for this cytokine response was investigated. METHODS: Rats were subjected to occlusion of the superior mesenteric artery for 45 min. (SMAO45), 75 min. (SMAO75), SMAO for 45 min. and 30 min. reperfusion (SMAO45/30), or sham SMAO, and then killed. Mucosal membranes from the terminal ileum were mounted in a Ussing chamber. E. coli C25 was added to the mucosal side of the stripped gut epithelium in half of the chambers. TNF and IL-6 levels on mucosal and serosal side of the stripped gut epithelium were assessed serially over 3 hrs. Gut barrier function was assessed by in vitro bacterial translocation (BT) and the transepithelial resistance (TER) of the mucosal membrane. RESULTS: The TNF response was greatest in the SMAO75 group, the IL-6 response in the SMAO75 and SMAO45/30 groups. In the absence of E. coli C25. IL-6 was produced to a greater extent on the serosal side, while addition of bacteria led to a significantly increased TNF/IL-6 response at the mucosal side of the stripped gut epithelium. BT was increased in SMAO75 and SMAO45/30 rats. Baseline TER was decreased in all experimental compared to sham SMAO groups. Although gut barrier function was impaired after intestinal ischemia/reperfusion there was no correlation between intestinal cytokine response and gut permeability. CONCLUSIONS: The gut becomes a cytokine liberating organ alter intestinal ischemia/reperfusion. This cytokine response is affected by certain conditions, but is not directly related to an impaired intestinal barrier function.
Animals↗
[Bone healing--an immunoreactive process?].
Cell mediated immune reactions, demonstrated by leukocyte migration assay and histological analysis of spleen and lymph nodes, could be observed after fresh autografting of cortical segments in rats. The detected immune answer showed a bone-specific reaction pattern. In consideration of the temporal correlation of the observed immune reactions and the histological signs of graft incorporation, a connection of bone healing and immune system may be possible.
Animals↗