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Biomedical subjects

H E Hart

Publications and source records attributed to H E Hart.

17 recordsLinked to original sources
PubMed1980

Multiple photon coincidence tomography.

Coincidence scanning devices that measure the distribution of radioisotopes emitting multiple photons in nuclear cascade decays offer a possible supplementary approach to tomography in nuclear medicine. Design factors that serve to determine resolution, sensitivity, and statistical noise for the multiphoton coincidence linear scanner (MCLS), the total organ kinetic imaging monitor (TOKIM), and related systems have been well studied. Focused collimator coincidence scanner (FCCS) systems are capable of extremely high resolution--spherical cold lesions of less than 0.2 cu cm volume being easily detectable. Although FCCS scan speeds are too slow for imaging of large organs, scan times for small organs or for the rescanning of suspicious or ambigous regions appearing on conventional scans are well within practical clinical limits. In view of recent developments in the on-site cyclotron production of short-lived radioisotopes and the current interest in high resolution localization of neurologic receptors in vivo, FCCS systems may prove also to be of value in basic neurophysiologic studies.

Elementary Particles↗
PubMed1979

Scintillation-proximity assay of antigen-antibody binding kinetics: concise communication.

Tritiated latex particles and scintillant latex particles have been covalently coated with an antigen (human albumin) and both types of particles are than combined in dilute aqueous suspensions. The formation of antibody-induced dimer and higher-order aggregation resulted in scintillations that could be measured in a standard liquid-scintillation counter, energy-gated for H-3. Rabbit anti-human antiserum was easily detected at a titer of 1:10(6). Human albumin, in the inhibition mode, was also easily detected at 0.1 ng/ml. Since the samples are nondestructively assased, it was possible to examine the kinetics of aggregation under a variety of conditions.

Albumins↗
PubMedDate not supplied

General practice registration networks in the Netherlands: a brief report.

In the Netherlands, several general practice registrations exist. Groups of general practitioners register elements of patient care according to agreed-upon criteria, and these data are collected in a central database. By means of a questionnaire the authors interviewed the managers of all nine computerized registration networks extensively about the possibilities and limitations of their registration. In addition, respondents answered some questions with data from the central database of their network. Various items are collected by nearly all the registration networks, while other items are collected by only one network. Answering questions with data from the central database turned out to be difficult. Organization and manpower are the main obstacles.

Databases, Factual↗