PSYCHOACTIVE DRUGS.
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Biomedical subjects
Publications and source records attributed to H E HIMWICH.
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Exacerbations of schizophrenic behavior are associated with elevations of urinary tryptophan metabolites. Free tryptophan and methionine possibly arising from the breakdown of muscle protein may act like an endogenous metabolic factor which enhances behavioral worsening. Some of the apparently spontaneous activations of psychotic symptoms may be intensified by the endogenous liberation of these two compounds.
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In studies with reserpine and with etryptamine, quite opposite electroencephalographic effects were obtained when either of these two drugs was administered to rabbits prior to surgical preparation for EEG recording as opposed to the drug being given after the rabbits had been fully prepared for EEG recording. With the one method, EEG rhythms indicative of sleep were obtained, while with the other method, EEG rhythms indicative of central nervous system stimulation were obtained, although with both methods, the amount of drug, duration of drug in animal, and type of acute preparation were identical for both sets of findings. The presurgical injection procedure produced EEG results more in accordance with behavioral and biochemical findings, even though the conventional procedure is to administer the experimental drug after the animal has been prepared for EEG recording.
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