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Biomedical subjects

H E Geissler

Publications and source records attributed to H E Geissler.

29 records · Page 2Linked to original sources
PubMed1977

[Serotonin].

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Animals↗
PubMed1977

[On the determination of azapropazone from plasma by direct quantitative thin-layer chromatography (author's transl)].

For the purpose of investigating drug interactions, a new selective method for determination of 5-dimethylamino-9-methyl-2-propyl-1H-pyrazolo[1,2-a] [1,2,4]benzotriazine-1,3(2H)-dione-dihydrate (azapropazone, Prolixan 300) was developed. The method is based upon the direct quantitation of the drug by thin-layer chromatography using remission measurement. The method is well suited for routine analysis of numerous samples, because of its simplicity and rapidity. The standar deviation of the method is about +/-4% at therapeutic plasma concentrations.

Administration, Oral↗
PubMed1977

[Azapropazone plasma levels under simultaneous treatment with an antacid or laxative].

Azapropazone is a non-steroid antirheumatic drug, commonly used in long-term treatment of inflammatory and non-inflammatory rheumatic diseases. Since antacids and laxatives are often taken simultaneously the present study was concerned with the influence of a concomitant treatment with medium doses of dihydroxy-aluminium sodium carbonate, magnesium aluminum silicate, bisacodyl and anthraquinone cathartics on steady-state plasma levels of azapropazone when azapropazone was given as an oral dose 3 times daily to 15 patients. Azapropazone plasma levels were determined 5 h after azapropazone administration by a direct quantitative thin-layer chromatographic method. Azapropazone plasma levels during simultaneous treatment with antacids were 70.3 +/- 14.1 microgram/ml in comparison to 75.4 +/- 16.5 microgram/ml after azapropazone alone (p = 0.10). After the administration of the laxatives a mean plasma concentration of 68.2 +/- 10.1 microgram/ml was obtained, without laxative the average plasma level of azapropazone accounted for 65.1 +/- 8.1 microgram/ml (p greater than 0.05). There were virtually no effects of simultaneous treatment on azapropazone plasma levels. The results suggest that azapropazone can be given together with antacids and laxatives since there is no significant interaction.

Adult↗
PubMed1976

[On the determination of triamterene, hydroxythiamterene and hydroxytriamterene sulphate ester in biologica material by direct evaluation of thin-layer chromatograms (author's transl)].

The quantitative measurement of 2,4,7-triamino-6-phenylpteridine (triamterene), as well as its metabolites hydroxytriamterene and hydroxytriamterene sulphate ester, is described. Estimation of urine, plasma and faecal samples was achieved by a direct fluorometric method following separation on kieselgel plates. The procedure allows the simultaneous assay of the three substances on the plate without the need for previous chromatographic separation or derivatisation.

Chromatography, Thin Layer↗
PubMed1975

[The content of free serotonin in urine after resection of part of the gastro-intestinal-tract (author's transl)].

The elimination of free serotonin (5-hydroxytryptamine) in 24 h urine, from patients with gastric carcinoma before operation and from patients following 2/3 gastrectomy (Billroth II), intestinal- or colon-rectum-resection, was measured using direct quantitative thin-layer chromatographic-fluorometry. By comparison with a heterogeneous control group a lowered elimination of free serotonin was observed in patients with gastric carcinoma and following colon-rectum-resection. The remaining groups showed no significant difference with the control group.

Colectomy↗