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Biomedical subjects

H E Eckel

Publications and source records attributed to H E Eckel.

113 records · Page 7Linked to original sources
PubMed1990

[Endolaryngeal laser surgery in the treatment of laryngeal cancers. The current Cologne concept].

Tumors can be resected in two different ways using endolaryngeal laser surgery. 1. After taking a biopsy from the lesion for histological purposes, the remaining tumor is completely vaporized. This method is only to be used in the treatment of premalignant lesions, as it does not allow a clear histological examination of the boundaries of such lesions. 2. The laser is used as a "scalpel", allowing a complete resection of laryngeal tumors in one block and a histological assessment of the margins. In the treatment of carcinoma in situ and severe dysplasia, we perform a laser-decortication of one or both vocal cords, leaving the vocal muscle intact (endolaryngeal laser-resection type I). Limited carcinomas of one vocal cord undergo a cordectomy, leaving the anterior commissure behind (endolaryngeal laser-resection type II). Extended and bilateral vocal cord carcinomas are treated by an extended cordectomy, which can comprise resection of one of the arytenoid cartilages if necessary (endolaryngeal laser-resection type III). Vocal cord carcinoma with extension to one or both false cords (stage T2) require a complete resection of one or both vocal and false cords in combination with an arytaenoidectomy, if necessary. The resection comprises the inner perichondrium of the thyroid and cricoid cartilages as well as the cricothyroid membrane (endolaryngeal laser-resection type IV, endolaryngeal exenteration).

Follow-Up Studies↗
PubMed1990

[Preliminary results of endolaryngeal laser resections of laryngeal cancers].

From 1986 to 1988 ninety four patients with carcinoma of the larynx were treated by endoscopic laser surgery. Follow-up ranges from 3 to 39 months with a mean value of 23 months. Ninety patients were operated on with curative intent and 4 with palliative intent. In 7 cases of T3 tumors a complete removal of the tumor was not possible, so that a total laryngectomy could not be avoided. In all cases of T2 cancers of the glottic and subglottic level a definite resection was possible. Follow-up investigations showed 3 recurrences in the larynx so far. These were treated by laryngectomy. Recurrences in the cervical nodes were seen in two patients following resection of a supraglottic and a subglottic tumor. The authors believe that laser surgery may obviate the need for total laryngectomies in certain stages of laryngeal cancer, especially in T2 tumors. T3 tumors should not be treated by endolaryngeal laser surgery. At present, the number of recurrences and the rate of survival show no significant difference to those after conventional surgery. The phonatory function is not always predictable, and still needs to be investigated.

Adult↗
PubMed1988

[Prevention and therapy of synechia following laser resection of laryngeal tumors].

Laser resection of vocal cord carcinomas often requires the exstirpation of the ventral commissure and exposure of the thyroid cartilage to ensure complete excision of the tumour. The appearance of synechia near the commissure is a frequent complication of such operations. Even intensive conservative postoperative treatment does not effectively combat this complication. A newly developed operative technique is presented for the prevention and/or treatment of such synechia or granulation after endolaryngeal laser surgery. The method is also documented photographically.

Aprotinin↗
PubMedDate not supplied

Morphometry of the larynx in horizontal sections.

PURPOSE: Until recently, only few studies on laryngeal morphometry in the horizontal plane, which used unreliable techniques, have been reported. The established methods of whole-organ serial sectioning of the larynx serve the purpose of histological investigation very well. Because they cause major tissue shrinkage, these techniques are not useful for morphometry. Nevertheless, normal data of laryngeal horizontal anatomy are of great surgical and diagnostic interest. Data on endolaryngeal angles, airway lumina, and the thickness of parts of the laryngeal skeleton can be helpful in the planning of endolaryngeal surgical intervention or the transcutaneous placement of electrodes for laryngeal electromyography. The aim of this study was to establish a method for the production of whole-organ serial sections that allows for the collection of exact and reliable morphometrical data. MATERIALS AND METHODS: A total of 20 fresh human cadaver larynges were investigated in this study. Nineteen measurements on three different planes were obtained in each larynx. The larynges were shock-frosted using liquid propane and nitrogen and then cut with a slicing machine. Measurements were obtained using a computer-aided analyzing system. RESULTS: The collected data give an exact and extensive description of the morphometrics of laryngeal structures such as thyroid and cricoid cartilage, arytenoid cartilages, vocal cords, and endolaryngeal airways at different section levels. CONCLUSION: This study is the first to provide detailed anthropometric data on whole-organ sections of the larynx following a new method. This technique of using serial sections of the investigated specimen avoids artifacts caused by tissue fixation. Thus, it may be considered being particularly suited to the conduction of anthropometric studies on human larynges.

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