[Sperma immunity in the female].
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Antibodies↗
Biomedical subjects
H Donat
Publications and source records attributed to H Donat.
[Identification and characterisation of immune cells in the ejaculate of infertile and fertile men].
Using the immunoperoxidase technique with monoclonal antibodies the ejaculates of 20 infertile and 15 fertile men were examined for lymphocyte subsets and activation markers to know more about the cellular mucosal immunity in the male genital tract. The results have shown that there are small differences of T-helper (CD4), T-suppressor (CD8), B- (CD19) and Natural Killer cells (CD57) between both groups. The number of monocytes (CD14), activated T- and B-cells and macrophages (CD25), the LCA-positive cells (CD45) and the HLA-DR-positive cells were remarkably increased in fertile patients. It has been established that the number of NK-cells (CD57) correlated with mycoplasma infection and the B-cells (CD19) correlated with the testosterone level. It seems that the increased testosterone value improved the cellular immunity. Infertile men have a disturbed mucosal immunity and a higher rate of genital infections.
Antigens, CD↗
[Fertility of workers exposed to herbicides and pesticides].
Twenty-one workmen exposed to herbicide as organic mercury compounds and to pesticide as halogenic hydrocarbon has been investigated concerning their fertility. If the concentrations of organic mercury compounds increase in the air of the place of employment then the levels of this heavy metal are also higher in the urine and in the ejaculate, and the fertility is reduced. It could also be established that a correlation exists between the concentration of pesticide in the place of employment and the male fertility, especially in cases with an excess of maximum permitted concentrations.
Adult↗
[Immunoglobulins in human seminal plasma].
Immunoglobulins were determined by radial immunodiffusion in seminal plasma of 168 men of infertile couples. IgA and IgG were found in all samples in measurable concentrations. IgM was seen only in 61 (36,3%) samples of seminal plasma. Whereas the IgG-level is constant in various qualities of ejaculates, the IgA-level decreases at azoospermia and increases at oligozoospermia and bad morphologia. Autoimmune reactions are discussed as cause of these changes in testes, epididymis or accessory glands.
Humans↗