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Biomedical subjects

H Doi

Publications and source records attributed to H Doi.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

Hepatocellular carcinoma with tumor thrombus in the inferior vena cava and right atrium.

Tumor thrombus (TT) in the inferior vena cava (IVC) and right atrium (RA) is rarely encountered. We have diagnosed before death and treated a case of hepatocellular carcinoma (HCC) with TT in the IVC and RA, accompanied by a brain metastasis. The image characteristics on computed tomography (CT), magnetic resonance imaging (MRI), and conventional angiography are discussed.

Brain Neoplasms↗
PubMedDate not supplied

Hemodynamics of small hepatocellular carcinomas (5 cm or less in diameter): cases with discrepant findings between dynamic MR images and hepatic arteriograms.

BACKGROUND: The degrees and patterns of contrast enhancement of small hepatocellular carcinomas (HCCs) on dynamic magnetic resonance (MR) images were compared with those on hepatic arteriograms in 61 patients. METHODS: Dynamic MR imaging was performed within 1 week before hepatic angiography prior to treatment, 3-4 weeks after treatment, and then once every 1-3 months if necessary. Hepatic arteriography was carried out with a coaxial microcatheter inserted into the proper hepatic artery or its distal branches. RESULTS: In 58 of 61 cases, the degrees of contrast enhancement of the tumor in dynamic MR imaging were roughly consistent with those in hepatic arteriography before treatment. In the remaining three cases, however, the tumors were depicted as hyperintense in the arterial dominant phase of the dynamic MR imaging, whereas the tumors were not detected by hepatic arteriography. The tumor detectability is 97% by dynamic MR imaging and 92% by hepatic arteriography. Furthermore, when an HCC nodule was not clearly enhanced by hepatic arteriography after treatment, it was possible by dynamic MR imaging to obtain accurate information on whether the HCC nodule had parasitic arteries. CONCLUSIONS: Dynamic MR imaging was superior to hepatic angiography in contrast resolution. It was therefore considered to be useful in assessing the degrees and patterns of contrast enhancement of small HCCs before and after treatment.

Aged↗
PubMedDate not supplied

Lipiodol retention and massive necrosis after lipiodol-chemoembolization of hepatocellular carcinoma: correlation between computed tomography and histopathology.

This retrospective study examined the computed tomography (CT) criteria for judging the effectiveness of transcatheter arterial Lipiodol-chemoembolization (Lp-chemo-TAE) in 35 cases with hepatocellular carcinoma (HCC). Massive necrosis, defined as involving 97% or more of the HCC nodule, was observed in 15 cases after Lp-chemo-TAE, whereas nonmassive necrosis, defined as involving < or = 96% of the HCC nodule, was observed in the remaining 20 cases. In 12 of 15 cases (80%) with massive necrosis, uniform dense retention of Lipiodol (Lp) was observed throughout the HCC nodule on CT images 3-4 weeks after Lp-chemo-TAE as opposed to only one (5%) of 20 cases with nonmassive necrosis (p < 0.01). Eight of nine cases (89%) with massive necrosis had tumor attenuation values of 365 Hounsfield units (HU) or greater on CT images 3-4 weeks after embolization, as opposed to only four (27%) of 15 cases with nonmassive necrosis (p < 0.01). We conclude that the effectiveness of the Lp-chemo-TAE can be judged on CT from the degree and duration of Lp retention in the HCC nodule and the measurement of the attenuation value of the HCC nodule.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Macrophage depletion prevents anti-graft antibody production and results in long-term survival in xenotransplantation.

Liposome-encapsulated dichloromethylene diphosphonate (clodronate) is known to deplete macrophages. We examined the effect of clodronate on xenoreactive antibody production and xenograft rejection. Hamster cardiac grafts were transplanted into Lewis rats. Clodronate (4 mL/kg) was injected intravenously on the day before transplantation. In some groups, cyclosporine A (CsA) at a dose of 15 mg/kg was given daily intramuscularly until the end of each experiment. Untreated Lewis rats rejected the grafts at 2 and 3 days after transplantation. Neither CsA treatment alone nor clodronate treatment alone prolonged graft survival. Five of 7 Lewis recipients treated with clodronate and CsA did not reject hamster hearts for 100 days. Antibody production in the CsA plus clodronate-treated group was suppressed compared with control groups.

Animals↗
PubMedDate not supplied

Tumor thrombus in the branches of the distal portal vein: CT demonstration.

Punctate and linear low density structures adjacent to the tumor nodules in the CT images of eight patients with hepatocellular carcinomas were followed for greater than 5 months to investigate the evolution of these low density structures. During the period of follow-up, patients were given anticancer therapy. Computed tomographic, angiographic, and autopsy examinations indicated that the CT finding of punctate or linear low density structures represented a tumor thrombus in the portal branches of the third and more distal orders. In two cases that showed punctate or linear low density structures adjacent to the distal side of the tumor nodules to the porta hepatis, a daughter nodule was detected by CT at 6.5 and 9.2 months, respectively, after the appearance of the low density structures. In two cases that showed punctate or linear low density structures adjacent to the proximal side of the tumor nodules to the porta hepatis, rapid and extensive tumor growth was found by CT at 5.4 and 8.0 months, respectively, after the appearance of the low density structures.

Aged↗
PubMedDate not supplied

Dynamic MRI of the diaphragm.

OBJECTIVE: To demonstrate the appearance of the diaphragm on single-slice dynamic MRI. MATERIALS AND METHODS: We evaluated the diaphragm using gadolinium-enhanced single-slice dynamic MR in 53 patients. RESULTS: The diaphragm was partially depicted in 49 cases (92.5%). Its thickest part measured 4.4 +/- 2.2 mm, range 3 to 15 mm. Enhanced high-intensity thin layer structures were partially identified between the diaphragm and liver parenchyma in 46 cases (86.8%) at 16 to 144 s (mean +/- SD, 65.7 +/- 32.6 s) after intravenous injection of Gd-DTPA. CONCLUSION: Dynamic MR has value and limitations in demonstrating the diaphragm.

Carcinoma, Hepatocellular↗