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Biomedical subjects

H Dehen

Publications and source records attributed to H Dehen.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Stress-induced analgesia (author's transl)].

The effects of a repetitive stress (expectation of severe pain) on the threshold of a nociceptive flexion reflex of the lower limb (Rlll, Bi) were investigated in normal subjects. A progressive and significant rise of the Rlll, Bi Threshold was observed as the stress was repeated several times over a 60 to 90 minutes' period. This effect was entirely reversed by naloxone, with fall of the threshold below initial values. In a double-blind test, the injection of a placebo had no significant effect on the reflex threshold when compared with control values. These results are in agreement with those reported in animals. They provide experimental evidence for an involvement of endogenous opiate systems in the mechanism of stress in normal subjects.

Adult↗
PubMed1982

[Clinical and electrophysiological study of isaxonine in peripheral facial paralysis (author's transl)].

In a double-blind survey carried out versus a placebo, the action of isaxonine was examined with 42 patients suffering from peripheral facial paralysis, most often a frigore. The statistical analysis of the clinical and electrophysiological results shows a significantly higher improvement for the isaxonine group, both in quality and speed of recovery of the nervus facialis functions. Clinical and biological tolerance posed no particular problem.

Double-Blind Method↗
PubMed1981

Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes.

The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. Tha data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.

Adult↗
PubMed1981

Cutaneous reflexes in the avoidance reaction.

An electrophysiological study of cutaneous reflexes in a patient exhibiting an avoidance reaction in the upper limb has essentially demonstrated simultaneous activation of flexor and extensor muscles. The avoidance reaction is not the electrophysiological reciprocal of the grasp reflex; the former shows, in at least one aspect, a much more fundamental disturbance of segmental reflex systems controlling muscle contraction.

Aged↗
PubMed1979

[Failure of voluntary eyelid closure, motor impersistence and hemispheric functional specialization. A report on 3 cases (author's transl)].

The impossibility of voluntary closing of the eyelids is usually reported in the published literature as being associated with bilateral cerebral lesions. In the three cases reported by the authors, this rare symptom was caused by unilateral lesions of the right hemisphere. The inability to close the eyelids voluntarily is, with these types of lesion, a transient sign which is rapidly replaced by difficulty in maintaining the consign. The physiopathology of motor impersistence (neglect of instructions), and of absence of voluntarily closing of the eyelids may be connected. Two associated mechanisms are discussed : preferential activation of the left hemisphere during a verbal consign and a fault in interhemispheric inhibition.

Aged↗
PubMed1979

[Electrophysiological study of cutaneous reflexes during avoidance reaction of the arms (author's transl)].

Electrophysiological studies of the cutaneous reflexes during avoidance reaction of the arms demonstrate more particularly the presence of facilitation of late reflex responses and stimultaneous activation of flexor and extensor muscles. The avoidance reaction is not the inverse electrophysiological image of pathological prehension, as it produces, at least in one of its aspects, a much more fundamental modification of the segmental reflex systems of muscle contraction regulation. This motor disorganization is rarely observed, and could result from a disequilibrium between proprioceptive sensitivity and skin sensitivity: the loss of proprioceptive control would facilitate contact reactions.

Aged↗
PubMed1978

Congenital insensitivity to pain and the "morphine-like" analgesic system.

Congenital insensitivity to pain remains without a satisfactory physiopathological explanation. In an electrophysiological study on a nociceptive flexion reflex of the lower limb, the effects of naloxone and of placebo were compared in 8 normal subjects and in a patient with congenital insensitivity to pain. In normal subjects, no significant change in the reflex threshold was observed with naloxone or with placebo. In contrast, two electrophysiological abnormalities characterized the patient: (1) spontaneous elevation in the nociceptive reflex threshold of 350% as compared to control, and (2) a large (67%) and rapid (2--3 min) fall of this threshold for about 10 min following the administration of naloxone. These results raise the problem of the relationship between congenital insensitivity to pain and an hyperactivity of a naturally occurring "morphine-like" pain-inhibitory system.

Adult↗
PubMed1978

[Insensitivity to pain: electrophysiological study of the nociceptive reflex. Influence of naloxone (author's transl)].

Electrophysiological studies of the nociceptive reflex (R3) were carried out in eight normal subjects, and one patient with congenital insensitivity to pain, in order to compare the effects of naloxone and a placebo. No significant variation in the reflex threshold was seen in the normal subjects. Two electrophysiological abnormalities were observed in the patient: a 350 per cent spontaneous elevation in the R3 threshold compared to the control group; a rapid and large drop (67 per cent) in the threshold lasting for about ten minutes after the injection of Naloxone. These results suggest that in this particular case the insensitivity to pain could be related to the permanent hyperactivity of a morphine-like inhibitory system.

Adult↗
PubMed1977

[The action of acupuncture on pain. Physiological basis].

A review of experimental studies concerning acupuncture gives a current indication as to the neurophysiological mechanisms of its hypoalgesic effects. In man, these effects are demonstrated by study of the nociceptive flexion reflex. Other methods for the study of pain threshold have revealed a hypoalgesic action in man and in the animal. The authors analyse the pathways and structures necessary to analgesia: peripheral afferent pathway, ascending pathways, suprasegmental controls. The inhibitory mechanisms activated by acupuncture appear to be identical to those involved in analgesia by morphine and by central stimulation.

Acupuncture Therapy↗