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Biomedical subjects

H Dedichen

Publications and source records attributed to H Dedichen.

At least 37 records · Page 2Linked to original sources
PubMed1976

The papaverine test for blood flow potential of ileo-femoral arteries.

To establish drug and an optimal dose for a pharmacological test of the blood flow potential of an artery, the effect of intra-arterial injection of papaverine in varying doses was observed. The response to papaverine was then compared with that of other vasodilating drugs and with the physiological vasodilation of sympathectomy, exercise and postischemic hyperemia. In reconstructed atheromatous arteries, the injection of 40 mg papaverine HCl was found to induce a maximal local flow response, increasing blood flow in artery by approximately 250%. In normal arteries the response was higher. Tolazoline and isoxuprine induced a lower blood flow response and a higher fall in systemic blood pressure. The flow induced by papaverine was higher than flow after sympathectomy and light exercise and amounted to 88% of the maximum seen after 5 minutes ischemia. It is concluded that the blood flow induced by intra-arterial injection of 40 mg papaverine HCl represents a useful reference for flow potential of this artery.

Adult↗
PubMed1976

Hemodynamics in arterial reconstructions of the lower limb. I. blood flow.

In order to establish normal and critical rates for peroperative, arterial blood flow, measurements were performed on 230 ileo-femoro-popliteal arteries subjected to reconstruction for atherosclerosis. Mean, basal blood flow after reconstruction was 134, 254 and 372 ml/min in the s. femoral, c. femoral and c. iliac arteries in vessels remaing open. These flow rates increased to a maximum of 375, 822 and 975 ml/min after intra-arterial injection of 40 mg papaverine. Flow rates were significantly lower in operations followed by early failure. In successfully reconstructed arteries, the mean, basal flow was restored to normal, but flow amplitude was still reduced, diastolic backflow was rarely seen and the flow-response to intra-arterial papaverine was significantly less than in normal arteries. Critical flow rates could not be defined but the frequency of primary failure increased significantly when basal blood flow after reconstruction was less than 100 ml/min or the papaverine induced flow was less than 200 ml/min. Preoperative blood flow was found to correlate well with the primary results of the operation while correlation with late results was less evident.

Adult↗
PubMed1976

Hemodynamics in arterial reconstructions of the lower limb. II. Blood pressure.

In order to demonstrate common pressure gradients and peripheral arterial pressure in ileo-femoro-popliteal arteries before and after reconstruction for atherosclerosis, intra-operative pressure measurements were performed on 204 patients. Before reconstruction, the pressure differential was 44.3 mmHg in femoro-popliteal arteries and 29.0 mmHg in the iliac arteries. This was reduced to 8.4 and 4.1 mmHg by the reconstructions. In patients with femoro-popliteal disease, the pressure gradient was higher when gangrena or rest pain were present than when claudication was the principal symptom. When the iliac arteries were mainly involved, no such difference was seen. Postoperative gradients were slightly higher in arteries subjected to primary failure than in vessels remaining patent. The blood flow increase from intra-arterial papaverine injections accentuated existing pressure gradients and frequently disclosed gradients not manifest at basal flow rates.

Adult↗
PubMed1975

Reactive hyperaemia of the human lower limb. A comparison between the effect of tourniquet occlusion, selective arterial occlusion and intra-arterial papaverine injection.

Reactive hyperaemia of the lower limbs in 30 non-atherosclerotic subjects and in 24 patients operated for arterial occlusive disease was investigated preoperatively by electromagnetic flowmetry of the femoral artery. In normal limbs maximal flow values after 5 minutes of tourniquet occlusion averaged 482% of basal flow. Maximal flow increased little when occlusion time was extended beyond 2 minutes. This indicated that occlusion times shorter than the conventional 5 minutes were sufficient in clinical reactive hyperaemia tests. Selective occlusion of the normal femoral artery induced a maximal flow, which was about 50% of that obtained by tourniquet occlusion. The flow increase observed after papaverine injection in this group was 88% of the response induced by 5 minutes of tourniquet occlusion. After arterial reconstruction 5 minutes of selective occlusion of the reconstructed artery induced a maximal flow, which was only 150% of basal flow, whereas papaverine injection increased blood flow to 261.0% of basal level in this group. It is concluded that the hyperaemia induced by intraarterial papaverine injection is considered a useful index of the possibility of flow increase after arterial reconstructions.

Femoral Artery↗
PubMed1972

[Septic shock].

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Acid-Base Equilibrium↗