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Biomedical subjects

H Dahl

Publications and source records attributed to H Dahl.

At least 55 records · Page 3Linked to original sources
PubMed1984

Zinc therapy of acetazolamide-induced side-effects.

A double-blind cross-over trial extending over 4 weeks with administration of 0.2 g zinc sulphate 3 times daily and a placebo was carried out on 12 patients having grave acetazolamide-induced side-effects manifesting themselves as gustatory disorder, anorexia, and paraesthesia. All the patients had S-zinc levels within the normal range. These rose during zinc therapy periods, to fall again within placebo periods. Recording of the degrees of subjective side-effects based on interviews showed the side-effects to abate towards the conclusion of the trial period, independently of the randomizing programme. In other words, no significant difference was demonstrable between zinc period and placebo period. Taste tests according to Börnstein showed the gustatory disorders to be related exclusively to beverages containing carbon dioxide. However, in no more than 3 out of 10 patients did the gustatory sense return to normal after administration of zinc and one after placebo. Thus, this controlled trial has not served to disclose any statistically significant effect of zinc administration on acetazolamide-induced side-effects.

Acetazolamide↗
PubMed1983

Human interferon and cell growth inhibition. VII. Reversibility of interferon activities.

Interferon (IFN) components isolated from human leukocyte-derived alpha IFN preparations were tested for reversibility of activities in four different human cell lines. As expected, antiviral activity was not reversed by removal of the IFN-containing medium. Growth inhibition by the anticellular component was completely reversible by washing of the cultures, while that of the antiviral component could not be reversed even after careful washing. The results with the components are in agreement with the findings with IFN in the different cell lines. The present study support earlier suggestions that at least two mechanisms of action are involved in growth regulation by IFN in various cell lines.

Antiviral Agents↗
PubMed1978

Countertransference examples of the syntactic expression of warded-off contents.

This is a preliminary statement of the hypothesis that syntax in speech may act as an "incidental stimulus" in the communication of mental contents which the speaker is motivated both to conceal and to express. Ten clinical examples, taken from verbatim transcripts of one psychoanalyst's interventions in a recorded case, illustrate the expression of countertransference attitudes by syntactic and other linguistic properties such as: the agentless passive, pronominal ambiguity, yes/no questions, extraposition, the pseudocleft construction, delaying tactics, the passive construction and conceptual focus, lists and logical complexity, foregrounding, syntactic and lexical ambiguity, subordinate clauses and syntactic opacity.

Communication↗
PubMed1977

Human interferon and cell growth inhibition. II. Biological and physico-chemical properties of the growth inhibitory component.

Human leukocyte interferon (IF) inhibits the growth rate of homologous cells in culture. The growth inhibitory component, formerly separated from the antiviral component of human leukocyte IF by adsorption chromatography on albumin-agarose, is investigated. The properties of the component are compared with the accepted characteristics of IF. The growth inhibition is caused by a small molecule, unstable to pH 2 treatment with HCl, but stable to trichloro-acetic acid (TCA) and to proteolytic enzymes. The siolated growth inhibitor seems to be a dimer of molecular weight (mol wt.) approximately 2300. It is activated by heat treatment and lacks species specificity. The discrepancies in the properties of the growth inhibitor before and after separation from IF are discussed.

Animals↗
PubMed1977

Differentiation between antiviral and anticellular effects of interferon.

The antiviral and anticellular activities can be differentiated by biological, genetical, biochemical, and physico-chemical methods. The investigations on physical separation of activities suggest the anticellular effects to reside in a low MW molecule firmly associated with the antiviral molecule. Whether all or just some of the anticellular effects reside in this molecule is still unsolved.

Cell Division↗
PubMed1976

Interferon in the serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders.

The presence of interferon (IF) was investigated in serum and cerebrospinal fluid (CSF) from neurological patients. Significant titres of IF were found both in the serum and in the CSF in about half of the patients suffering from acute encephalitis and from multiple sclerosis (MS), but not in patients suffering from various non-inflammatory disorders in the central nervous system (CNS) or in the peripheral nervous system (PNS), and not in the serum of healthy blood donors. Significant IF titres in the CSF were regularly associated with significant titres in the serum, but the converse was not true. Interferon levels were not correlated to cell counts in the CSF; nor to concentration of IgG and albumin in serum and CSF; nor to presence of electrophoretically oligoclonal IgG patterns; nor to hemagglutinating and gel-precipitation antibodies against measles. IF levels were lower in the serum of patients having reduced serum/CSF ratios for measles antibody than those with normal ratios. The data may indicate that MS is linked to factors which induce IF production in the CNS.

Antibodies↗
PubMed1976

The effect of ascorbic acid on production of human interferon and the antiviral activity in vitro.

The effects of ascorbic acid on interferon production and on the antiviral effect of interferon in cultures of human cells were investigated. Ascorbic acid enhanced the interferon levels produced by human embryo skin and human embryo lung fibroblasts, induced by Newcastle disease virus and by polyinosinic-polycytidylic acid. The same concentrations of ascorbic acid had no effect on interferon production in two lymphoblastoid cell lines induced by Sendai virus. Leucocyte interferon assayed in lung fibroblasts titrated 0.2-0.3 log10 units higher in the presence of 5 mug ascorbic acid than in the absence of the latter.

Ascorbic Acid↗
PubMed1976

Human interferon and cell growth inhibition. I. Inhibitory effect of human interferon on the growth rate of cultured human cells.

Human interferon inhibited the growth rate of cultured human cells. These included diploid fibroblast cells from embryonal lung and skin, established lines of HeLa and U-amnion cells, all grown in monolayer; and the established lymphoblastoid line P3HR1 grown in suspension. Cells growing fast were inhibited to a higher degree than those growing slowly. The inhibitory effect was dose dependent but the dose-dependency was different in various cell types. The inhibitory effect of leukocyte interferon and fibroblast interferon was quantitatively comparable.

Cell Count↗
PubMed1973

Enhanced effect of repeated administration of bacterial vaccine against viral respiratory infection.

Administration of a standard bacterial vaccine (SBV) affords some protection against influenza infection in mice if given 4 to 5 h before inoculation of the virus. This effect was enhanced by repeated injections of SBV 7 and 14 days earlier, as measured by the length of survival, mortality rate, development of gross pneumonia, and virus multiplication in the lungs. Serum interferon levels were likewise enhanced by immunization with SBV, which may, at least in part, explain the increased preventive effect.

Animals↗