Biomedical subjects
Publications and source records attributed to H Dadan.
69 patients with rectal cancer were operated in years 1987-1996. Anastomosis was performed using stapler in 35 patients or hand suture in 34 patients. The authors analysed influence of the anastomosis technique and additional treatment on early and long-term postoperative results.
The authors have made a review of the present literature relating to lithogenic bile as the main pathogenic factor in the creation of cholelithiasis. Lithogenic bile is formed in result of complex biochemical reactions taking place in bile under physiological conditions, as well as in pathology of the liver and the biliary tract. Significant clinical implications result from the analysis.
In the years 1972-1995 41 patients suffering from prolapse of the rectum were operated according to the Moore method. The method is based on the observations which suggest that the cause of prolapse is intestinal intussusception which can be prevented by translocating the anus under the pubic joint. The observation time is from 1 to 23 years. Two patients were reoperated; one-as a result of a recurrence of rectal prolapse and one due to a post-operative adhesive ileus. One patient died as result of peritonitis following an overlooked microperforation in the rectal wall. In the case of the remaining patients, the treatment was fully successful. Regular defecation cycle as well as incontination of stool and flatus returned and the anal sphincters almost fully regained their tension in comparison to the pre-operative state. Early and distant results of surgery of prolapse of the rectum are satisfactory.
On the basis of biochemical and morphological research, the authors decided to attempt to determine the degree of lithogenicity of the bile among patients suffering from cholecystolithiasis (100 patients) and those not suffering from this disease (31 patients). Having analyzed the obtained data, it can be concluded that the degree of lithogenicity of bile is influenced by the concentration of cholesterol, bile acids and phospholipids as well as the damage of the liver and of the wall of the gallbladder as well as its kinetics. Lithogenic bile was noticed in 84% of the patients of group I and in 54% in group II. However, the degree of lithogenicity was significantly higher in patients suffering from cholecystolithiasis. According to the authors, the degree of lithogenicity is the deciding factor in the creation of bile stones.
The purpose of the study was evaluation of laparoscopy in the diagnosis of cirrhosis and chronic hepatitis. The studied material comprised 197 cases of cholestasis in which for diagnostic-prognostic purposes laparoscopy was done. During visual observation of the abdominal cavity in 81 cases cirrhosis and in 25 chronic hepatitis was diagnosed. The reliability of the laparoscopic diagnosis was verified by the microscopic verification of the material obtained by guided biopsy of the liver or during operation. Among 81 cases of cirrhosis diagnosed during laparoscopy histological confirmation was obtained in 68 cases (83.9%). In the group of 25 cases with laparoscopic diagnosis of chronic hepatitis the diagnosis was confirmed histologically in 21 (84%) cases. The authors believe that laparoscopy extends the diagnostic possibilities in liver diseases. However reliable diagnosis can be obtained by microscopic examination of liver fragments obtained by guided biopsy or operation.
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Histochemical researches on livers of 19 dogs were carried out. The dogs suffered from extrahepatic cholestasis which lasted for 28 days and was surgically induced. The dogs were divided into three groups, out of which two were given phenobarbital for 21 or 28 days. In all groups biliary obstruction was removed by surgical operation. It was shown that a combined surgical treatment with the application of phenobarbital has given better results than a surgical treatment alone.
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