Antigen driven selection for Fc receptors of enhancing antibody on macrophages during an alloimmune response.
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Animals↗
Biomedical subjects
H D Whitten
Publications and source records attributed to H D Whitten.
Facilitation of macrophage-mediated destruction of allogeneic fibrosarcoma cells by tumor-enhancing IgG 2 in vitro.
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Animals↗
Prolonged survival of murine fibrosarcoma allotransplants by anti-enhancing Fab alloantibody.
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Absorption↗
A synergistic immunosuppressive effect of endotoxin and PHA-M on immunologic enhancement in mice.
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Animals↗
Dissection of the immunosuppressive effect of the Fc region of tumor-enhancing IgG.
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Animals↗
Immunological dysfunction in Alzheimer's disease.
Peripheral blood lymphocytes from Alzheimer's patients and apparently healthy elderly individuals were examined for interleukin-1 (IL-1) production. Our results indicate severely low production of IL-1 by patient's peripheral blood monocytes. The low production of IL-1 in vitro correlated with patients' symptoms and therapy with 1-acetamide,2-pyrrolidone (1a,2p). In addition to low IL-1 production, the number of autologous rosette forming cells (ARFC) was significantly decreased in all Alzheimer's patients whereas B-cell glucose metabolism was significantly higher than age-matched healthy individuals.
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