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Biomedical subjects

H D Rott

Publications and source records attributed to H D Rott.

At least 91 records · Page 5Linked to original sources
PubMed1975

[Present situation of prenatal diagnosis of neural tube defects].

Anencephaly and spina bifida both are malformations of unknown etiology which are caused by an absent or incomplete closure of the neural tube. The risk of recurrence for the malformations is 5% in families with one child with a neural tube defect and 10%, if two such children have already been born. Neural tube defects can be diagnosed already before 20th week of gestation by ultrasonics and alpha-fetoprotein measurement in amniotic fluid, if an underdeveloped neurocranium or a free communication between amniotic and cerebrospinal fluid is present. By these diagnostic techniques and possibly following interruption the probability in risk families can be significantly lowered.

Abortion, Legal↗
PubMed1975

[Incidence and etiology of omphaloceles (author's transl)].

Omphaloceles are congenital malformations with herniation of the abdominal viscera into the umbilical cord. The incidence in newborns is 1:4300, the sex ratio 1.24:1 in favour to boys. Children with this malformation are neither more frequent at the beginning nor at the end of the sibship; the average maternal age is not increased. In about 50% other different malformations are found. All those omphaloceles, which are found as an obligatory symptom in the EMG syndrome (Wiedemann-Beckwith syndrome) to be probably in most cases autosomal recessively inherited or which are seen within a chromosomal malformation syndrome are of etiologically known origin. Omphaloceles without other malformations are mainly sporadic, less frequent in sibs, possibly due to a polygenic or multifactorial mode of inheritance. Findings in population genetics and animal experiments suggest that exogenous factors, too, can be the cause of malformation syndromes with omphaloceles.

Abdominal Muscles↗