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Biomedical subjects

H D Riley

Publications and source records attributed to H D Riley.

At least 73 records · Page 4Linked to original sources
PubMed1977

"Gentamycin"--no!

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Gentamicins↗
PubMed1976

Pharmacokinetic model for serum concentrations of ampicillin in the newborn infant.

The time course of ampicillin concentrations in the sera of three newborn infants during and upon termination of intravenous infusion at a constant rate can be described by a two-compartment pharmacokinetic model. The parameters of the model were determined by simultaneously fitting the serum concentration data obtained during and after the infusion by means of a nonlinear regression program with the aid of a digital computer. The half-life of ampicillin in the infants ranged from 2.1 to 2.9 hr; these values are more than twice those observed in adults with normal renal function.

Ampicillin↗
PubMed1976

Antibiotic susceptibilities of 120 strains of Staphylococcus aureus isolated from patients at a Children's Hospital. Decline of hospital staphylococci as compared with staphylococci in outpatients. A reversal.

The antibiotic sensitivities of 120 strains of Staphylococcus aureus isolated from both hospitalized patients and outpatients at Children's Memorial Hospital, Oklahoma City were studied. The proportions of strains resistant to the commonly used antibiotics were considerably lower than that found by other workers in earlier years, except for penicillin G. Of the 120 strains, 98 (81.7%) were resistant to penicillin G, 13 (10.8%) to tetracycline, 9 (7.5%) to erythromycin, and 3 (2.5%) to clindamycin. No strains resistant against cephalothin, chloramphenicol, gentamicin, or oxacillin were found. Sixteen strains (13.3%), of which 5 were inpatient strains and 11 were outpatient strains, were found to be resistant to more than one drug. Phage group 1 or type 80/81 staphylococci were not found among multiple resistant strains from hospitalized patients.

Anti-Bacterial Agents↗
PubMed1975

Effect of enrichment procedure upon auxotroph recovery in Escherichia coli K-12.

Proline-requiring auxotrophs are recovered preferentially after mutant enrichment procedures (e.g., penicillin) which perturb the cell envelope, but not after procedures (e.g., thymineless death) which affect other cellular targets. This probably stems from effects of penicillin and similar antibiotics upon proline metabolic and transport enzymes associated with the cell envelope.

Escherichia coli↗