Inzolen, a combination of the potassium, magnesium, copper, manganese and cobalt salts of aspartic acid, inhibits the second phase of ADP-induced aggregation probably by affecting the membrane-located adenylatecyclase/phosphodiesterase system. Correspondingly inzolen affects the activation of platelet factor 3 (PF3), which is also located in the platelet membrane. Thus spontaneous as well as kaolin-induced platelet factor availability is reduced by inzolen. The significant inhibition of factor 3 availability can be interpreted by a magnesium-mediated activation of phosphoryltransferases.

Aspartic Acid↗

PubMed1979

Comparative investigations on the quantitative determination of ADP-and adrenaline-induced aggregation by means of a microscopic test and an electronic platelet counting method.

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Adenosine Diphosphate↗

PubMedDate not supplied

[Drugs of plant origin and the vascular system].

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Animals↗