Search PubMed⌕ Search

Biomedical subjects

H D Perry

Publications and source records attributed to H D Perry.

At least 91 records · Page 5Linked to original sources
PubMed1986

Systemic tetracycline hydrochloride as adjunctive therapy in the treatment of persistent epithelial defects.

Recent evidence shows tetracyclines have anticollagenolytic activity that may be clinically effective in disease treatment. This led us to use systemic tetracycline (oral tetracycline hydrochloride 1 g daily divided into 4 doses) as adjunctive therapy in treating 18 patients with persistent corneal epithelial defects. Fourteen of 18 patients healed their defects; within 48 hours (9 patients) and within two weeks (the other 5 responding patients). Two patients showed no effect and two showed disease progression.

Adolescent↗
PubMed1986

Chronic lymphangiectasis in Turner's syndrome.

A 3 1/2-year-old female presented with Turner's syndrome and Nonne-Milroy-Meige disease. Ocular findings included strabismus and bilateral chemosis which was unchanging and persisted throughout the four years the patient was followed up. Histopathological findings included diffuse lymphangiectasia and dense connective tissue surrounding the dilated lymph channels. Although the association between congenital lymphoedema and Turner's syndrome is common, the lymphoedema usually disappears by the first year of life. The persistence of the lymphoedema beyond this age is rare, as is the presence of the persistent chemosis. This report represents the first histopathological documentation of congenital lymphangiectasis in association with Turner's syndrome.

Child, Preschool↗
PubMed1986

Serious corneal complications associated with extended-wear soft contact lenses for myopia.

Three patients wearing extended wear contact lenses for correction of myopia presented with severe corneal complications including corneal ulcers and corneal infiltrates. All cases were assembled over a four-month period, reflecting the alarming rise in severe corneal complications related to increased usage of these lenses. We feel indiscriminate dispensing and lack of proper follow-up care are primary contributing factors in the near epidemic rise in severe corneal problems related to this usage. Two of our three patients had significant permanent visual loss following resolution of their contact lens problems.

Adolescent↗
PubMed1986

Retinal arteriolar occlusion in multiple sclerosis.

A 25-year-old white man presented with acute multiple sclerosis manifested by right blindness, difficulty urinating, and paresthesias and weakness of both legs. Retinal examination revealed a distal occlusion of the descending branch of the superior temporal arteriole leading to an area of retinal ischemia of the right eye. The optic disc was edematous, and there were focal areas of periphlebitis. All retinal signs resolved in three weeks, and the only abnormality that persisted was a pale right optic disc. The finding of small arteriolar disease is unusual and may represent another possible pathogenetic mechanism in multiple sclerosis.

Adult↗
PubMed1985

A clinicopathologic study of contact-lens-related keratoconus.

A patient, initially examined at the age of 16 years and monitored for almost two decades, had corneal warpage and keratoconus associated with contact lens wear. Although the patient was advised repeatedly of the risk of continued contact lens use, she persisted. Contact-lens corrected visual acuity continued to deteriorate in the left eye (from 20/20 to 20/200) and keratometric readings continued to increase (from 43.50/44.12 to 56/59). The patient eventually required a corneal transplant in the left eye because of advanced keratoconus. The host button was subjected to light and electron microscopy, which disclosed keratoconus of the round cone type. Spectacle-corrected visual acuity was 20/20 18 months postoperatively.

Adolescent↗
PubMed1985

Epithelioid cell nevus of the iris.

A 21-year-old woman had a progressively enlarging pigmented tumor of the iris and anterior chamber angle in the right eye. Because the lesion was suspected to be a malignant melanoma, it was removed by an iridocyclectomy. Histopathologic examination disclosed the tumor to be a benign epithelioid cell nevus. This article describes the clinical and pathologic features of this rare iris tumor.

Adult↗
PubMed1985

Superficial reticular degeneration of Koby.

Koby in 1927 described a progressive, superficial corneal degeneration in a middle-aged woman that led to a painless loss of vision. This condition was characterized by the appearance of a central, fine, white reticulum at the level of Bowman's layer. The epithelium was thickened and bedewed, giving a faint brownish opalescence and providing a striking contrast to the white reticulum. We evaluated a patient with this rare corneal degeneration, and present clinical findings as well as the results of a superficial corneal biopsy. The biopsy was evaluated by light and electron microscopy and provides the initial documentation of this entity as an atypical form of band keratopathy.

Aged↗
PubMed1985

Systemic tetracyclines in the treatment of noninfected corneal ulcers: a case report and proposed new mechanism of action.

Corneal melting refers to a condition in patients whose corneas undergo progressive necrosis of stromal tissue despite being culture negative. Recent evidence has shown that systemic tetracyclines demonstrate anti-collagenolytic activity that may have clinical effectiveness in disease treatment. The evidence led us to try this modality as adjunct therapy in the treatment of an 80-year-old white man with a noninfected corneal ulcer. One gram of tetracycline in four divided doses led to a dramatic resolution of the corneal ulcer. This positive result supports the new concept that tetracycline therapy inhibits tissue collagenolytic enzyme activity by a mechanism unrelated to its antibacterial efficacy and may prove useful in the treatment of nonspecific corneal ulceration.

Administration, Oral↗
PubMed1984

A new method for inferior capsulotomy in the face of ruptured zonules.

During routine planned extracapsular cataract extraction, rupture of the inferior zonules was noted while performing the superior portion of the anterior capsulotomy. After the nucleus expression and cortical aspiration, a Sheets glide was placed in the anterior chamber between the anterior and posterior capsule, deep into the capsular bag. This provided a platform for the performance of a controlled inferior capsulotomy in the face of weakened zonular support.

Cataract Extraction↗
PubMed1982

Iris nodules in von Recklinghausen's Neurofibromatosis. Electron microscopic confirmation of their melanocytic origin.

A 75-year-old man had generalized neurofibromatosis (NFT) with bilateral iris nodules and a mature cataract with elevated intraocular pressure in his left eye. At the time of intracapsular cataract extraction, a sector iridectomy was performed. Electron microscopic studies of the iris nodules within the iridectomy specimen unequivocally established that the spindle-shaped cells within the nodules were of melanocytic origin. We believe that the iris nodules in NFT represent melanocytic hamartomas.

Aged↗
PubMed1982

Isolated episcleral neurofibroma.

A 22-year-old white woman presented with an epibulbar tumor of the right eye first noted seven years previously. Clinical examination showed a 6 x 8 mm lobulated yellowish white tumor rising 3-4 mm off the inferior bulbar surface. An excisional biopsy revealed the tumor to be free of conjunctival attachments and be firmly fixed to the sclera. Smaller nodules were noted away from the main tumor and posterior to the equator. The histopathologic evaluation revealed the tumor to be an isolated episcleral neurofibroma. Although rare, isolated episcleral neurofibromas should be thought of in the differential diagnosis of epibulbar tumors and treated conservatively.

Adult↗
PubMed1981

Subconjunctival lymphoma: a review of six suspected cases and the use of immunologic surface markers.

Six cases of subconjunctival tumor clinically compatible with the appearance of subconjunctival lymphoma were evaluated. Two of the patients, Cases 1 and 2, were under treatment with either prednisone or gold therapy for severe rheumatoid arthritis. Patient 3 manifested further evidence of systemic disease (auxillary lymph node). Of the remaining cases, patient 4 had no further evidence of systemic involvement, whereas patient 5 was suspected of having a gastrointestinal tumor. The last case, a patient known to have pulmonary lymphoma, presented with dry eye and multiple subconjunctival lymphomatous masses. Immune surface marker studies demonstrated a B-cell monoclonal subconjunctival lymphoma, suggestive of an improved survival when compared to null cell-type lesions. Immune surface marker studies offer a new commercially available method for classifying and prognosticating subconjunctival lymphomas.

Aged↗