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Biomedical subjects

H D Curtin

Publications and source records attributed to H D Curtin.

At least 73 records · Page 4Linked to original sources

Imaging of the larynx and cervical trachea.

Few new concepts have been introduced recently into the literature on imaging of the larynx and cervical trachea. Instead, the applications of recent technical advances have been further investigated. Most of the interest was directed at imaging of laryngeal cancer using CT and MR imaging. Several papers addressed ways in which imaging makes an impact on case management by detecting tumor extension not obvious to the clinician who uses a mirror or endoscope to directly visualize the larynx.

Humans↗

The effect of clinical history on chest radiograph interpretations in a PACS environment.

The effect that accompanying patient information has on diagnostic accuracy in radiologic interpretation has been studied by many researchers but remains a matter of contention. Experiments in the past emphasized the chest film because this procedure is the one done most frequently in radiology. However, with the increasing importance of digital imaging, the role of patient history in these procedures should be assessed. The use of a model computerized patient history in the interpretation of digitized chest images that were displayed on a high-resolution workstation was studied. Two hundred forty-seven selected posteroanterior chest images that indicated disease and that indicated no disease were interpreted in random sequence by five board-certified radiologists, with and without accompanying patient histories. Readers were prompted by the response forms to evaluate images for the possible occurrence of interstitial diseases, nodules, or pneumothorax. No significant differences (P = .05) in the detection of these abnormalities were noted between case readings with and without history for any of the radiologists or for the group as a whole. However, this methodology reflects a direct interpretation approach. The results of this study may not necessarily be applicable to individual prompts, different imaging procedures, or other abnormalities.

Hospital Information Systems↗

Malignant external otitis: utility of CT in diagnosis and follow-up.

Malignant external otitis is a severe bacterial infection of the bone and soft tissues of the base of the skull that is frequently difficult to diagnose. The effectiveness of antibiotic therapy is likewise difficult to assess. Serial computed tomographic (CT) scans were obtained in 11 consecutive patients with malignant external otitis at time of diagnosis and periodically after conclusion of antibiotic therapy. All patients demonstrated abnormalities of the external auditory canal, with or without bone destruction. Soft tissue or fluid in the middle ear and mastoid, around the eustachian tube, and in the parapharyngeal space (both pre- and poststyloid) was seen in greater than 50% of the cases. While remineralization of bone was not seen, soft-tissue disease improved dramatically, and recurrence or persistence could be corroborated by detection of more extensive soft-tissue changes. By delineating the extra- and intracranial extent of disease, serial CT scans enable one to make the diagnosis, determine the extent of infection, document recurrence, exclude progression, and confirm resolution of malignant external otitis.

Blood Sedimentation↗

Hypointense paranasal sinus foci: differential diagnosis with MR imaging and relation to CT findings.

Despite the plethora of information provided by magnetic resonance (MR) imaging that allows differentiation of some substances that are indistinguishable at computed tomography (CT), there are diagnostic problems. In particular, there are several quite disparate substances that all appear as either low signal intensity or signal void on T1-weighted images and even lower signal intensity or signal void on T2-weighted images. These substances include air, desiccated secretion, mycetomas, acute hemorrhage, calcium, bone, and enamel. When they are surrounded by material that has long T1 and T2 relaxation times, a not uncommon MR appearance in the sinonasal cavities, they may be impossible to differentiate from one another. The current explanations for the low signal intensities are presented, the similarities in the MR appearance are illustrated, and the use of CT to resolve diagnostic problems is discussed. CT appears to be the best modality for initially examining patients with suspected routine inflammatory disease or fungal infection.

Aspergillosis↗

Magnetic resonance imaging of the paranasal sinuses.

MRI has been very helpful in evaluating tumors in the paranasal sinuses. MRI can differentiate retained secretions from tumors. The multiplanar capabilities of MRI are also very helpful in identifying tumor margins. Although a specific diagnosis can be suggested in most cases, demonstration of the extent of the disease and specifically the relationship to key surgical landmarks is more important. Structures of thin cortical bone are better seen with CT than MRI. For several reasons, CT is still the examination of choice for evaluation of the osteomeatal complex and inflammatory disease of the sinuses.

Carcinoma, Squamous Cell↗

Otologic manifestations of Langerhans' cell histiocytosis.

Eighteen of 62 children diagnosed with Langerhans' cell histiocytosis at the Children's Hospital of Pittsburgh (Pa) between 1970 and 1986 demonstrated ear and temporal bone involvement. In six children, such otologic disease was their sole presenting manifestation. Common signs and symptoms included aural discharge, postauricular swelling, and conductive hearing loss. The otologic findings in these children, if not investigated properly, could easily be attributed to acute or chronic infectious ear disease. Computed tomography with contrast enhancement proved to be particularly valuable as a diagnostic study because of its clear delineation of both osseous and soft-tissue temporal bone involvement. Computed tomographic findings could also be used to enhance local treatment by guiding surgical biopsy and curettage procedures or defining low-dose radiation therapy portals. Eleven of these 18 children with otologic Langerhans' cell histiocytosis additionally required chemotherapy due to the systemic nature of their disease.

Child↗

Imaging of the larynx: current concepts.

Not every laryngeal abnormality requires imaging. If a lesion is small and there is no evidence of deep extension, the clinician can derive all visual examination. Similarly, when a lesion is large and obviously involves both true and false cords (transglottic), the clinician already knows that a total laryngectomy is necessary and imaging is of little value unless there is a question about nodal involvement. The real value of imaging is in the questionable cases in which a decision must be made about the feasibility of speech conservation therapy. The radiologist must understand the various conservation techniques and the key information needed to determine the feasibility of each. In cases in which patients are able to cooperate with the examination, MR with multiplanar imaging capabilities and increased tissue differentiation has, in my view, an edge over CT. However, many patients cannot cooperate, and in these cases CT provides a more consistently good examination. Some centers rely totally on CT and some rely completely on MR imaging units with low or middle field strength. Either can give excellent laryngeal imaging. At my institution, with a high-field-strength unit, MR imaging is the first choice if the patient is fairly cooperative and is thought able to undergo the examination. Even if the patient cannot tolerate the entire protocol, the examination usually provides enough necessary information. If the patient has major problems with secretions or has difficulty cooperating, we do not try MR imaging but use CT; the examination is almost always adequate even though restricted to one plane. The imaging modality used is less important than the radiologist's knowledge of the key anatomic landmarks. The most important landmarks, from a surgeon's perspective, are the ventricle, anterior commissure, and the cricoid cartilage. The structures most helpful in identifying the position of the ventricle are the paraglottic fat, the thyroarytenoid muscle, and the arytenoid cartilage. The clinician remains responsible for evaluating the mucosal surface. The goal of the radiologic examination is to find deep tumoral extension that the clinician cannot see.

Glottis↗

Floating petrous bone fracture.

Floating petrous bone fracture appears to occur when the elastic pediatric skull is subjected to large compressive forces. Unlike a longitudinal fracture, a floating petrous bone fracture does not involve the ear canal and squamous cortex. Rather, the fracture line runs through the middle ear, separating the petrous apex from its lateral and inferior bony attachments. Characteristic clinical findings include immediate onset of conductive hearing loss, with ipsilateral sixth and seventh cranial nerve paralysis. This article details the third known occurrence of this type of fracture, and includes a discussion of the pathophysiologic mechanism and treatment rationale.

Child↗

Bilateral optic disc colobomas with orbital cysts and hypoplastic optic nerves and chiasm.

A 3-month-old boy with bilateral optic disc colobomas and orbital cysts is presented. Both eyes appeared relatively normal in size. Ultrasonography on one side demonstrated a communication between the globe and cyst by way of the optic disc coloboma. On computed tomography and magnetic resonance imaging, the cysts' contents were similar to vitreous. The optic nerves and chiasm appeared markedly hypoplastic on neuroimaging tests. Fluorescein angiography, electroretinography, and visual evoked responses suggested that the visual deficit primarily was ascribable to optic nerve or anterior visual pathway dysfunction.

Coloboma↗

MR of the salivary glands.

MR has become the examination of choice for imaging salivary gland neoplasms. The improved soft tissue contrast of MR represents a significant improvement over CT, particularly for extension outside the gland. The appearance of various tumors and inflammatory processes is described.

Cysts↗

Congenital anomalies of the temporal bone.

Inner ear anomalies are a rare but important cause of sensorineural hearing loss. Combined external and middle ear anomalies are more common, causing conductive hearing loss and cosmetic deformity. The course of the facial nerve canal is altered in many temporal bone anomalies. Its location is of great importance when surgical therapy is anticipated. Vascular anomalies and bone dysplasias occasionally affect the temporal bone. High resolution CT, using thin sections and edge enhancement techniques, is capable of demonstrating the finer bony details of these temporal bone anomalies.

Ear↗

Modern imaging in ear, nose and throat problems.

Advances in imaging have had a considerable effect on the workup of many ear, nose and throat problems. The traditional plain films and tomography gave a limited amount of information compared to the more recent advances of ultrasound, computed tomography and magnetic resonance. The rapid advances in imaging further complicate the decision-making process with respect to the most appropriate imaging modality for each clinical situation. A brief description of the more frequently used examination is followed by an approach to imaging in various clinical problems.

Diagnostic Imaging↗

Fungal sinusitis: diagnosis with CT and MR imaging.

Of 293 patients who underwent computed tomography (CT), surgery, and pathologic examination for chronic sinusitis, 25 had a diagnosis of fungal sinusitis at pathologic examination. Of these, 22 had foci of increased attenuation at CT (in four patients the mean representative CT number [Hounsfied unit] was 122.2 HU [SD, 8.2 HU]), and three did not. Of the 22, 19 patients (76%) met the CT criterion of this study (there was a 12% false-positive and a 12% false-negative diagnostic rate). Six of the 19 patients and one additional patient underwent magnetic resonance (MR) imaging, and all demonstrated remarkably hypointense signal characteristics on T2-weighted images. The findings at MR imaging therefore appear more characteristic of fungal sinusitis than the findings at CT. Furnace atomic absorption spectrometry showed increased concentrations of iron and manganese in mycetoma compared with their concentrations in bacterially infected mucus. This finding and the presence of calcium in the fungal concretion may explain the hypointense T2-weighted signal on MR images.

Adult↗

Facial paralysis: traumatic neuromas vs. facial nerve neoplasms.

Traumatic neuromas (TN) are benign proliferations of neural tissue that may occur without disruption of the facial nerve. The clinical presentation, as well as the radiographic appearance, may suggest neoplastic involvement of the facial nerve. Histologically, they may closely resemble neurilemomas (Schwannomas) or neurofibromas. Three cases of TN of the facial nerve associated with facial paralysis are presented here. Unlike previously reported cases, these tumors were not associated with chronic inflammatory middle ear disease. TN must be considered in the differential diagnosis and treatment of facial paralysis.

Adolescent↗

Assessment of salivary gland pathology.

At this institution, inflammatory problems and calculous disease are evaluated by plain films or sialography. CT can be used for stone evaluation but is not usually necessary. Although CT has been the mainstay of tumor evaluation, magnetic resonance imaging has several very definite advantages and is likely to supercede CT as the procedure of choice.

Diagnostic Imaging↗

Congenital malformations of the ear.

Either CT or pluridirectional tomography is capable of demonstrating bony anomalies of the ear. For a variety of reasons, high-resolution "bone algorithm" CT is used as the first imaging procedure at our institution, and pluridirectional tomography is done only on rare occasion, usually when there is an ambiguity on the CT images.

Bone Diseases, Developmental↗