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Biomedical subjects

H D Brede

Publications and source records attributed to H D Brede.

At least 37 records · Page 2Linked to original sources
PubMed1985

Seroepidemiology of HTLV-III (LAV) in the Federal Republic of Germany.

In 1984 10,281 sera were collected in the FRG and examined for antibodies to HTLV-III (LAV) with an enzyme-linked immunosorbent assay and confirmative tests. Of the German AIDS patients 81% have antibodies. Individuals belonging to AIDS risk groups, homosexuals, haemophiliacs and i.v. drug abusers, have antibody frequencies between 25%-72%. The detection of HTLV-III antibodies in blood donors indicates that the virus is being transmitted by blood transfusions.

Acquired Immunodeficiency Syndrome↗
PubMed1984

[Active immunization against hepatitis B].

The efficacy of the hepatitis B vaccine Hevac B Pasteur was assessed in 277 persons over a period of 6 months. HBs antigen of 5 micrograms/dose was administered three times in monthly intervals. Before each vaccination and after 6 months 18 chemical pathology data and a clinical assessment were performed and all important serologic hepatitis markers (anti-HBs, anti-HBc, HBs antigen, HBc antigen, anti-HBe) were determined radioimmunologically. Within two months antibodies against the surface antigen (anti-HBs) had developed in 85.7% of vaccinees. After 6 months 93.1% of vaccines had become seropositive. Within the first two months anti-HBs-positive findings and higher anti-HBs concentrations occurred significantly more frequently (P less than 0.048) in females than in males. These differences had largely disappeared at the follow-up assessment in the sixth month. In contrast, both parameters (seroconversion rate and anti-HBs concentration) were age-dependent. Among vaccines of less than 25 years of age and of more than 35 there were significant differences after 6 months (P less than 0.005). The hepatitis B vaccine of the Pasteur institute can be considered immunogenic and safe.

Adult↗
PubMed1984

[Viral hepatitis B markers in physicians and medical personnel in the Rhein-Main region].

HBs antigen, anti HBs and anti HBc were determined radioimmunologically on 314 medical students, 585 doctors, 151 medical laboratory personnel and 307 nursing staff. Hepatitis B markers were present in 5.1% of medical students, 23.4% of doctors, 17.9% of laboratory personnel and 18.6% nursing staff. In the different groups there were up to 1.3% HBs antigen-positive persons. A large majority of persons with signs of previous hepatitis B infection had concentrations of both antibodies (anti-HBs and anti-HBc). Between 0.6 and 5.5% of persons were merely anti-HBc positive. Among doctors the number of positive results increased with age and professional exposure, no age dependence as to seropositive or seronegative being found in the other groups. None of the persons tested had been aware of a preceding hepatitis infection. These results indicate that doctors and medical personnel even today are at risk of an undetected viral hepatitis B.

Adult↗
PubMed1980

The human factor--the weakest link?

The German Animal-Laboratory-Information-System (ALIS) was used to assist the laboratory animal care program. The transmission of disease from man is a hazard to the health of laboratory animals. Mycoplasmas, Escherichia coli, staphylococci and Listeria were considered as hazards to laboratory animals. Special consideration was given to Escherichia coli strains of O groups 7 and 146 and to different lysotypes of Staphylococcus aureus. Important areas where human mistakes can be prevented are discussed. These include distance of animal quarters from processing areas, the diameter of sanitary sewers, air conditioning, noise, drinking water, cage changing procedures, wetting of animals, quarantine areas and separation of species. Training of laboratory animal technicians in Germany consists of both in-service and formal types. The formal training lasts 2 years. People selected for formal training should be tested to assure they are not allergic to laboratory animal dander.

Animal Husbandry↗
PubMed1976

The Enterobacteriaceae of South African baboons.

The results of routine rectal swab examinations, carried out on 776 baboons on the day of arrival at the colony and also on 394 animals which subsequently developed diarrhoea, are described. A dramatic increase was observed in the incidence of both pathogenic and non-pathogenic organisms during the diarrhoeic phase. The significance of bacterial species which are not pathogenic under normal circumstances as the possible cause of disease in animals subjected to stress is discussed.

Animals↗