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Biomedical subjects

H D Bolte

Publications and source records attributed to H D Bolte.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Immunological examinations in dilated cardiomyopathies].

Immunological data in dilated cardiomyopathies can differentiate the nosology of these diseases. In nearly one half of these dilated cardiomyopathies, binding of immunoglobuline in myocardial structures (biopsies) can be demonstrated. By immunohistological techniques collagen I in myocardial biopsies has been predominantly shown. In lymphocytes of the diseases patients the T-cell-suppressor activity is low. This phenomenon seems to play an important role in the pathogenesis of dilated cardiomyopathies and can explain numerous humoral immunological findings. As conclusion the hypothesis can be drawn: several cases of dilated cardiomyopathies and myocarditis can be regarded as different stages of a single underlying disease, in which a low T-cell-suppressor activity seems to act as a predisposing factor.

Antibody Formation↗
PubMed1981

Acute negative inotropic effect of adriamycin (doxorubicin).

The muscle mechanical and haemodynamic effects of adriamycin were investigated in guinea pigs and rats by use of isolated myocardium (isometric contractions of papillary muscles of guinea pigs and rats) and in situ preparations (haemodynamic parameters in thoracotomized rats). 1. Adriamycin (10-6 to 10-3 M) produced a concentration-dependent negative inotropic effect in papillary muscles of 21 guinea pigs (decrease of T max and dT/dt max to 80% of control) and in papillary muscles of 15 rats (decrease of T max and dT/dt max to 25% of control for maximally effective concentrations). 2. The haemodynamic parameters left ventricular pressure (LVP), dLVP/dt max, arterial pressure and cardiac output of thoracotomized rats (N = 12) decreased dose-dependently following i.v. injections of adriamycin at doses of 2-30 mg/kg until a lethal haemodynamic shock occurred. 3. "Low-dose-effects" were reversible within min, whereas "high-dose-effects" were not up to an observation period of 1 h. 4. In the haemodynamic experiments, the ionized serum calcium fell excessively after adriamycin (from 2.1 mEq/l for controls to 0.5 mEq/l after doses of 25 mg/kg adriamycin). 5. An antagonistic interaction was seen between the cardio-depressant effect of adriamycin and the positive inotropic effect of calcium and vice versa. 6. It is concluded that the acute muscle mechanical and haemodynamic effects of adriamycin result from an interaction between adriamycin and calcium.

Animals↗
PubMed1981

Computed tomography in constrictive pericardial disease.

Thirteen patients with pericardial abnormalities and a question of constrictive hemodynamics underwent contrast enhanced cardiac computed tomography (CT). Those with clinical and catheterization evidence of restricted cardiac filling demonstrated three CT signs: a dilated IVC, a deformed ventricular contour, and an angulated interventricular septum. Patients with pericardial fluid, thickening, or calcification but without evidence of constriction showed none of these signs. Cardiac CT also defined sites of particular constriction for subsequent resection.

Adult↗
PubMed1980

[Myocardial involvement in Fabry's disease (author's transl)].

Definitely impaired coronary reserve, as recorded in cases with coronary microangiopathy, was demonstrated in a 48-year-old female non-smoker with angina, positive ECG exercise tolerance test and negative coronary angiography with normal coronary circulation at rest. Myocardial biopsy from the right ventricle demonstrated electron-microscopically the lamellar, intracytoplasmic inclusion bodies described in Fabry's disease. This diagnosis of an X-chromosomal recessive metabolic disorder with prominent myocardial involvement was confirmed by the results of further investigations.

Angina Pectoris↗
PubMed1980

[Long-term therapy of tumor patients. Secondary cardiomyopathies (author's transl)].

Secondary cardiomyopathies may necessitate limitation of planned cytostatic or other drug therapy in tumor patients. Highly active cytostatics such as adriamycin, cyclophosphamide, ifosfamide, tricyclic antidepressants, beta-receptor blockers, antiarrhythmic substances may be mentioned among others. These noxae have a particularly harmful effect when secondary myocardial diseases of different etiology are present. A variety of different methods are available for the earliest possible detection of a secondary cardiomyopathy. Should functional disorders of the heart appear during longterm therapy it will be necessary to find out in the individual case what modifications of treatment are advisable, taking into account the benefits and risks.

Angiotensin II↗
PubMed1980

Dose-response relationship for a positive inotropic effect of insulin on isolated papillary muscle.

Beneficial effect of glucose and insulin on the myocardium are still a matter of discussion. The influence of insulin on isometric force of contraction of right ventricular papillary muscles of guinea pigs was studied. The papillary muscles were mounted vertically in a 95% O2, 5% CO2 modified Krebs-Hensuleit solution (31.5 degrees C, 5.5 mM glucose) and stimulated l/s. A positive inotropic effect of insulin was dedectable at a concentration of 5 x 10(-4) IU/ml insulin, was half maximal (52% above controle force of contraction) at 8 x 10(-3) IU/ml and maximal at 10(-1) IU/ml. The maximal positive inotropic effect was observed 4.7 +/- 0.6 min after addition of insulin. After the maximum there was a decrease to a steady state level of 109.8 +/- 8.5% of control (p less than 0.05) in 14.6 +/- 1.3 min. Higher glucose (16.5 mM) only shifted the half maximal positive inotropic effect to 5.5 x 10(-3) IU/ml insulin (n.s.). Inhibition of glycolysis with hypoxia or jodoacetate (5 x 10(-5) M) did not prevent the positive inotropic effect as known as 75% of control force was retained. When glucose transport was blocked with phlorizin (5 x 10(-3) M) or phloritin (5 x 10(-4) M) no positive inotropic action of insulin was observed. Therefore we conclude that the positive inotropic effect of insulin in isolated papillary muscles is mediated by inhanced glucose transport.

Animals↗
PubMed1980

Enzymatic analysis and collagen content in endomyocardial biopsy samples of patients with congestive cardiomyopathy of unknown etiology.

Endomyocardial biopsy samples from patients suffering from congestive cardiomyopathy of unknown etiology (COCM) were analyzed for lactate dehydrogenase (LDH) isoenzyme distribution by microisoelectric focusing. In addition, the concentration of collagen in the biopsy samples was estimated by determination of hydroxyproline and proline. The results were correlated with the clinical and hemodynamic data of the patients. Increased activities of total LDH and LDH5--the worse the hemodynamic parameters, the higher the concentration of LDH5--indicate an enhanced anaerobic glycolysis in the myocardium of COCM patients. The close correlation between the hemodynamic data and the LDH isoenzyme pattern suggests an association between severity of COCM and impairment of aerobic metabolism. The results of the alteration in the LDH isoenzyme pattern were not influenced by the collagen content in the myocardial biopsy samples. Varying isoenzyme patterns in the different parts and wall layers of the normal heart show the necessity of analyzing biopsy samples only from comparable localizations.

Biopsy↗