Search PubMed⌕ Search

Biomedical subjects

H D Becker

Publications and source records attributed to H D Becker.

At least 253 records · Page 14Linked to original sources
PubMed1984

Pancreatic polypeptide response to sham feeding in man.

The relationship between gastric acid secretion and the release of pancreatic polypeptide (PP) during modified sham feeding was studied in 29 duodenal ulcer patients and 10 healthy controls. Ulcer patients showed higher basal plasma PP levels than age-matched controls (p less than 0.01). Acid secretion and PP levels were stimulated in the majority of patients and controls during sham feeding; however, no correlation was found between basal and vagally stimulated acid secretion and basal PP levels. Gastrin levels did not change in both groups. It is concluded from the present study that changes in plasma PP levels do not reflect sham feeding induced stimulation of the parietal cells.

Adult↗
PubMed1983

[Surgery of hemorrhaging peptic ulcer].

Surgical therapy in upper gastrointestinal bleeding is preferred, if bleeding does not stop spontaneously or an increased risk of recurrent bleeding exists. Absolute indications for surgical intervention is given after blood replacement of 1500 ml/24 hs or 1000 ml in 4 hs, a recurrent bleeding after an initial stop, a continuous bleeding for 24 hours especially in patients over 50 years, the coincidence of bleeding and perforation, and an endoscopically proven visible vessel in the ulceration. A relative indication for surgical intervention is given in patients over 50 years of age, severe second illness in chronic ulceration, pain during active bleeding and problems in blood replacement. Principles of surgical therapy consist of local ligation, devascularisation of the bleeding area of the stomach, gastric resection or vagotomy in different forms. In most cases several therapeutical principles are used. Mortality of operations in active upper gastrointestinal bleeding is around 14%. Recurrent bleeding after operation will happen in about 9%. Bleeding stress ulcerations have a bad prognosis. At the Department of Surgery, University of Göttingen, 178 patients have been operated during the last years because of actively bleeding gastrointestinal ulceration. Total mortality was 12.9% (gastric ulceration 18.6%, duodenal ulceration 9.3%). The surgical therapy of choice has been ligation of bleeding vessel in gastric ulceration and local ligature of the afferent vessel together with stitching of the bleeding vessel under preservation of the pylorus in duodenal ulcer patients. In stress ulceration operation has to be avoided otherwise a vagotomy and resection is performed.

Age Factors↗
PubMed1983

[Hemobilia].

Hemobilia is caused by a pathological communication between the biliary tract and the intra- and extrahepatic blood vessels; multifarious pathogenetical mechanisms of this syndrome have to be considered. The trias of colicky upper abdominal pain, jaundice and haemorrhage in the upper gastrointestinal tract determinates the clinical picture. To ensure the diagnosis and to localize the source of bleeding sonography, endoscopic retrograde cholangiography (ERC) and coeliacography are indispensable. Besides the transvasal selective embolization ligature of the hepatic artery resection of the affected part of the liver just as reconstructive vascular operations serve as therapeutical tools in this disease. A patient complaining of intrahepatic hemobilia is described who was successfully treated by highly selective ligature of the respective vessel after intraoperative angiography through the stump of the cystic artery. Using this procedure the resection of the affected part of the liver could be avoided.

Adult↗
PubMed1982

Antral gastrin-producing G-cells and somatostatin-producing D-cells in different states of gastric acid secretion.

The number of G- and D-cells per area and the ratio of G/D-cells were investigated in biopsy specimens of the pyloric antrum from normochlorhydric subjects without peptic ulcer, from patients with duodenal ulcer, gastrinoma, pernicious anaemia, and after selective proximal vagotomy. Compared with normochlorhydric subjects antral G-cell density was significantly raised in pernicious anaemia, unchanged in duodenal ulcer, and diminished in gastrinoma patients. After vagotomy G-cell density was found to be raised if compared with patients with duodenal ulcer. D-cell density was significantly increased in gastrinoma patients, unchanged in duodenal ulcer, and diminished in pernicious anaemia and after vagotomy. The G/D-cell ratio was increased in pernicious anaemia and after vagotomy, unchanged in duodenal ulcer, and decreased in gastrinoma patients. It is concluded that the antral pH governs the ratio of G- and D-cells. Therefore, the G/D cell ratio increases in states of reduced acid secretion and decreases in massive hyperchlorhydria. Hypergastrinaemia as such does not affect the G/D-cell ratio.

Adult↗
PubMed1982

[Selective proximal vagotomy with ulcer excision or Billroth I resection in chronic stomach ulcer. A prospective randomized multicenter study].

In a prospective randomised multicenter study in 41 patients with chronic gastric ulcer type I according to Johnston we compared selective proximal vagotomy (SPV) plus ulcerectomy (21 patients) with a standardised Billroth I gastrectomy (20 patients). The follow-up period was at least 2 years. Preoperative characteristics of both groups did not differ. Intraoperatively, in 5 patients of the SPV group technical problems during dissection of the lesser curvature occurred. The main postoperative complaints were pain and epigastric fullness after SPV and bile vomiting, early dumping or diarrhea after Billroth I gastrectomy. 3 of 21 patients after SPV developed recurrent ulceration, whereas after BI resection no recurrence was observed. This study indicates a higher recurrence rate in gastric ulcer patients after SPV compared to Billroth I gastrectomy.

Clinical Trials as Topic↗
PubMed1982

[(Studies on intragastric titration in man) ].

The method of intragastric titration uses food particles for stimulation of gastric acid secretion and is characterised by an excellent reproducibility. The food stimulated gastric acid secretion is influenced by the pH-value of the stimulus, whereas concentration of the peptone solution and volume of the test meal is less important. Postprandial gastrin release, however is altered by pH of the stimulus concentration and volume of the test meal. Intragastric titration represents an excellent method for measuring gastric acid secretion and should mainly be applied to clinical pathophysiological studies.

Female↗
PubMed1980

Somatostatin and gastrin release from canine stomach.

Somatostatin and gastrin release into the veins draining the stomach was studied in 27 anaesthetized dogs. Basal somatostatin-like immunoreactivity (SLI) in corpus veins (136 +/- 36 pg/ml) was significantly higher than in antrum veins (83 +/- 20 pg/ml; p less than 0.05) and the femoral artery (58 +/- 15 pg/ml; p less than 0.02). During peptone, pH 6.5, perfusion of the stomach, SLI concentration increased significantly in the corpus veins to approximately four times basal and in the antrum veins to three times basal, whereas SLI levels in the peripheral circulation remained constant. Peptone, pH 3.5, and sodium oleate did not stimulate gastric SLI. Gastric distension increased significantly SLI release from the corpus. In gel filtration studies 50%--70% of SLI from gastric vein plasma samples but greater than 90% from femoral artery samples eluted in the void volume of Sephadex G-25 columns. Gastrin secretion was stimulated significantly only by peptone, pH 6.5.

Animals↗
PubMed1980

[Therapy of bleeding mucosal erosion of the stomach with secretin].

In a prospective study patients with bleeding from acute gastric mucosal lesions were treated by i.v. infusions of secretin. 67 patients received natural secretin (Karolinska-Institut Stockholm), 14 patients received synthetic secretin (Firma Hoechst Frankfurt). In 64 of the 67 patients (95%) who received natural secretin, bleeding stopped within the first 12 hours. In 18 of these 64 patients (28%) bleeding recurred after cessation of secretin infusion; all recurrences were stopped by secretin. In one of the 14 patients who received synthetic secretin, bleeding could not be stopped. In three of the remaining 13 patients bleeding recurred after cessation of secretin infusion, but could be stopped again by continuation of secretin infusion. Severe side effects were not observed. Secretin seems to be an effective drug in the treatment of stress ulcer bleeding.

Gastric Mucosa↗
PubMed1980

[Gastric acid response to food in duodenal ulcer patients before and after selective proximal vagotomy (SPV) (author's transl)].

In duodenal ulcer patients the maximal acid secretion induced by pentagastrin is significantly higher than the meal-induced acid secretion (10% peptone, pH 5.5). Three months after SPV there is no difference in pentagastrin and meal-induced stimulation. There is a reduction of 56% in insulin-negative patients after SPV, but only of 9% in insulin-positive patients. Basal serum gastrin levels increased significantly after SPV, but there is no difference in postprandial serum gastrin levels and in insulin-positive and insulin-negative patients. Intragastric titration seems to be a subtle method for testing the completeness of SPV.

Duodenal Ulcer↗