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Biomedical subjects

H Cuche

Publications and source records attributed to H Cuche.

30 records · Page 2Linked to original sources
PubMed1979

[Biochemical prospects in treatment of depressive illness (author's transl)].

Biochemistry of the brain has to avoid the dead-end where psychopharmacology is trapped at the present time. First of all it is needed to draw of the lack of efficacy of the antidepressants of today. Brain biochemical research must go beyond the moamine models and take into considerations the afferent and efferent influences. The sutdy of ECT and ions like lithium, rubidium, and cesium may open up new perspectives to the knowledge of new psychotropic drugs and to their mecanisms of action. Starting from clinical observations new indications for already known non psychotropic drugs could appear.

Antidepressive Agents↗
PubMed1979

[Classification of the antidepressants (author's transl)].

The antidepressants can be classified chemically. The standard division is between the tricyclic antidepressants and the chemically heterogeneous MAOIs. Many other compounds can be included among the antidepressants, e.g. the bicyclics and possibly also the beta-stimulants, the alpha-blockers and ions such as rubidium. As regards the mechanisms of action, we have the antidepressants which act selectively upon serotonin and those which act more particularly upon noradrenaline. This notion must be extended. Dopamine may be involved in certain depressive syndromes and also other systems may have a role, such as electrolyte systems, cell permeability and the multiple influences which have a bearing upon the monoamines. Finally, the effect upon receptors and their nature are discussed. A third type of classification refers to the therapeutic spectrum of the drug. We have the sedative antidepressants, active in agitated depression and the stimulant antidepressants which are active in retarded depression. However, the two categories of antidepressants have the same global antidepressant action.

Antidepressive Agents↗
PubMed1979

[Value of pharmacokinetic data during the treatment of psychoses with haloperidol].

Pharmacokinetic data of psychotropic drugs should allow a better understanding of therapeutic results and side effects. The different factors influencing liberation, absorption, protein binding, distribution, metabolism and excretion are reviewed. Then, the principal pharmacokinetic data of haloperidol are exposed with a special emphasis on the lack of information about the correlations between plasma levels and clinical effects. The role of pharmacokinetic informations in the interpretation of responses to treatment is detailed, wishing that the monitoring of haloperidol plasma levels will be more developped in a next future.

Haloperidol↗
PubMed1975

[A French experience with methadone].

Methadone chlorhydrate has been administred to opiate addicts either for a short period with a decreasing dosage as a withdrawal cure, or for longterm treatments as a basis of a maintenance program. The analysis of precise clinical criteria regarding the socio-professional states, the family-life, the general health and the psychopathological diagnosis, allows an evaluation of the success of the cure and of its elective indications. The study of the personnality of the drug-addicts shows the importance of this factor in the potential success of a methadone cure. Urinary biological controls are regularly performed. This limitations and promises of this treatment discussed form a basis of a year's experience.

Administration, Oral↗
PubMedDate not supplied

[Biological treatments of depression (author's transl)].

The different biological treatments of depression are first reviewed from an analytical point of view. The drugs are divided in three groups: the classical tricyclic antidepressants, the MAO inhibitors and the recent antidepressants. Some drugs with potential antidepressant properties are also studied. The other biological treatments of depression include electroconvulsive therapy and sleep deprivation. In a second step, the characteristics of these different treatments are detailed. Finally, the strategy of a drug treatment is considered with regard to the choice of the best drug and the best dosage for a given depressed patient.

Antidepressive Agents↗
PubMedDate not supplied

[Psychotropic drugs in primary care].

Nowadays psychiatrists and general practitioners are confronted with two realities which seem to be conflicting: psychotropic drugs are too largely prescribed while many depressed patients are not treated adequately. Any approach based upon clinical and/or pharmacological criteria is likely to oversimplify the medical practice in as much it generates too many clinical entities and shrinks drugs-induced effects to responses of isolated target. The specificity of any symptoms has to be evaluated within the limits of other associated symptoms and patient's personality. The treatment has to be carried out on a joined basis; the patient who has to be informed and the doctor who is also the patient's adviser. Patient's demand is changing, looking for permanent improvement of their well-being as well as improvement of their performances. The answer is clearly complicated and needs more knowledges and also deep concern on mankind.

Anti-Anxiety Agents↗