Search PubMed⌕ Search

Biomedical subjects

H Creutzig

Publications and source records attributed to H Creutzig.

At least 73 records · Page 4Linked to original sources
PubMed1977

[Comparative investigations of osteotropic radiopharmaceuticals. V. Demonstration of abnormal uptake with various scanners (author's transl)].

Experiments with phantoms have shown that there is a higher probability of showing areas of increased uptake when using a camera than with a scanner. In 49 patients with suspected bone metastases, scans were performed during their pre-operative work-up, under identical conditions, using a whole body scintigraphic scanner with a 5-inch double head and a scintillation camera with total body facility. The scintillation camera showed a significantly higher sensitivity to bone metastases, but there was no difference in the pick-up rate of distant metastases. Despite the possibly more frequent use of the camera, its cost is no higher than that of the scanner. Both on diagnostic and economic grounds, we consider the scintillation camera, with a total body facility, to be the instrument of choice for total skeleton scintigraphy.

Bone Neoplasms↗
PubMed1977

[Methodological observations on double radionuclide technics in joint scintigraphy].

Double-radionuclide scintigraphy for the differentiation between inflammatory and degenerative diseases of the joint ought to be performed with a radiopharmaceutical that remains within the intravascular space as an indicator of blood flow, and an osteotropic radiopharmaceutical. The former ought not to leave the intravascular space even in inflammatory disease. This condition is, however, not met by 113mIn-labelled transferrin as shown by measurements of plasma volumes as well as of its local kinetics. On the other hand, the biological behavior of 99mTc-labelled red cells does not, up to 30 min p.i., differ from that of 51Cr-labelled red cells so that they may be used as an intravascular tracer even in inflammatory disease. In that case, the osteotropic radiopharmaceutical to be employed should be 113mIn-EDTMP.

Arthritis↗
PubMed1976

Bone imaging after total replacement arthroplasty of the hip joint. A follow-up with different radiopharmaceuticals.

Bone imaging was done in patients after total replacement arthroplasty of the hip joint every 3rd month using 99mTc-HEDP and 18F. Uptake ratios were estimated over cup/normal hip and femur prosthesis/normal thigh. Ratios decline rapidly and reach a stable level 6-9 months, postoperatively. Eight cases of late infection were predicted correctly 1-3 months before any radiologic evidence was present. In four cases there had been false-positive results with 99mTc-HEDP while 18F gave always correct information except in cases of soft tissue inflammation. Here both 99mTc-HEDP and 18F ratios were elevated. The early diagnosis of late complications after replacement arthroplasty seems to be possible. The clinical significance, however, is low: only one out of eight patients with manifest infection is still on conservative treatment. Bone imaging should be done to exclude late infection as a cause of pain after total replacement arthroplasty of the hip joint only.

Arthroplasty↗
PubMed1976

[Salivary gland scintigraphy after radio-iodine therapy. Functional scintigraphy of the salivary gland after high dose radio-iodine therapy (author's transl)].

Following high dose radio-iodine therapy, some radiation damage to the salivary glands is to be expected since iodine is taken up by these glands. The great individual variation in the uptake makes it impossible to predict the severity of the damage. T max and maximal excretion capacity after stimulation were therefore estimated by a camera functional scintigram with digital read out in patients following radioiodine therapy (0.1-3.2 Ci); the excretion index was used as an indirect measure of salivary flow. After a dose up to 0.3 Ci there is a change of T max and maximal excretion capacity in 30% of patients; after a dose of 0.5 to 1 Ci it is found in 60 and 80% and after very high doses of 1.1 to 3.2 Ci an abnormal Tmax was found in two-thirds of all patients and reduced or absent excretion capacity in all nine patients in this group. The excretion index also depended significantly on the cumulative dose. All patients who had received very high doses showed marked hyposialia or asialia. The early results of interim examinations suggest, similar to radio-iodine induced hypothyroidism, a cumulative risk of reduced function. In view of the long survival period of patients with differentiated thyroid carcinomas attention should be drawn to this side effect.

Dose-Response Relationship, Drug↗
PubMed1976

[Is a dosage calculation for radio-iodine therapy possible?].

When trying a single-dose 131I therapy in thyrotoxic patients a dose calculation must be done to avoid an overtreatment raising the risk of posttherapeutic hypothyroidism. The calculation is based on the diagnostic 131I uptake, the thyroid weight, and the effective intrathyroidal halflife of the diagnostic 131I dose. In 46 thyrotoxic patients the radiation dose was calculated with 7000 R for small and 10 000 R for large (50--100 g) glands using the formula of Billion. Iodine-131 was given in a single dose. Therapeutic dose uptake was measured every day and the effective T 1/2 calculated using a least squares computer fitting to an monoexponential decrease. The radiation dose was then recalculated using the same formula. Small glands received 10 700 +/- 4300 R (SEM 1008 R) instead of calculated 7000 R; large glands 8600 +/- 4100 R (SEM 860) instead of 10 000 R. There was a significant correlation: the smaller the gland the higher the radiation dose. The smallest glands received 12 000 to 16 000 R. There might be such a great difference between calculated and received radiation dose than an individual prediction will be impossible. In our patients a careful calculation for the single-dose treatment was done; nevertheless in some cases an overtreatment of more than 100% was seen. A comparison of responding or overresponding to therapy with the radiation dose is only reliable using individual dosimetry with the therapeutic 131I dose.

Adult↗
PubMed1976

[Behavior of reactive shaft pseudarthroses of the canine radius in the electric and electromagnetic fields].

In 27 beagles, 19 radius shaft pseudarthroses and 8 tibia were stimulated either by directly applied alternating current of low frequency and strength, delivered from an implanted battery source, or by a pulsing electromagnetic field inductively coupled to bone. Increase of periosteal callus was only found beneath parallel sling electrodes placed on pseudarthroses parallel to the radius shaft. Stimulation by transverse electrodes implanted into bone produced no significant increase of osteogenesis and bone healing, evaluated by x-rays, scintigrams, and morphometry when compared with contralateral leg controls.

Animals↗
PubMed1975

[A comparison of osteotropic radiopharmaceuticals. II. Plasma clearance of 18F and 99mTc-EHDP (author's transl)].

Renal and extra-renal clearance of 18F and 99mTc-EHDP were compared in the same individuals. The 18F space is twice that of 99mTc-EHDP, as is its renal clearance. 99mTc undergoes glomerular filtration, 18F is excreted by glomerular filtration and tubular secretion. Extraction rate was determined indirectly by a comparison with extra-renal clearance, and for patients without bone disease it was four times as high for 18F as it was for 99mTc-EHDP. In patients with secondary hyperparathyroidism extra-renal clearance is greatly increased. This is explained by an increased extraction rate, which may be different for the two substances.

Bone Diseases↗
PubMed1975

[Comparative investigations concerning osteotropic radiopharmaceuticals. III. Scanning with 18F and 99mTc-malignant diseases (author's transl)].

Total body scans under identical conditions and using 18F and 99mTc-EHDP were carried out in patients with known, or subsequently proven, metastases. There was no statistical evidence for any difference in the number of scintigraphically demonstrable lesions. Patients with internal prostheses who developed infections of the prosthesis show no significant difference in the uptake of either nucleid. Soft tissue lesions showed a significantly higher uptake of 99mTc-EHDP than of 18F. 18F can be replaced for nearly all problems by 99mTc-EHDP without loss of diagnostic information.

Abscess↗
PubMed1974

[Letter: Goiter].

Explore the source record for details and available documents.

Diagnosis, Differential↗