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Biomedical subjects

H Creutzig

Publications and source records attributed to H Creutzig.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Differential nuclear medicine diagnosis of intrahepatic space-occupying diseases].

The use of ultrasonography has led to an increase of symptom-free carriers of intrahepatic masses. Whereas follicular nodular hyperplasia and haemangioma does not require further treatment, all other tumours should be resected. In a prospective study involving 81 patients with intrahepatic masses the value of nuclear medical methods for such a differentiation was assessed. In 21 out of 23 patients with follicular nodular hyperplasia and in 17 out of 18 cases of haemangioma a correct classification was achieved. In addition, all 3 adenomas and 36 out of 37 malignant tumours could be attributed correctly. Sequential and blood pool scanning of the liver as non-invasive methods thus permit differential diagnosis of intrahepatic masses with sufficient accuracy.

Diagnosis, Differential↗
PubMed1984

Scintigraphic imaging of renal angioma.

Renal angiomyolipomas are frequent findings in patients with tuberous sclerosis. They must be localized before a biopsy is done. Radionuclide blood pool scintigraphy is a simple noninvasive procedure for the localization of hemangiomatous tumours. A patient is presented with four renal angiomas shown by this technique.

Child↗
PubMed1984

Splenic regeneration and blood flow after ligation of the splenic artery or partial splenectomy.

In normal, young miniature piglets, either the major arteries and the veins were ligated or three quarters of the spleen was resected using three different techniques. These techniques served as an animal model for splenic salvage in human subjects. After arterial ligation, no signs of infarction could be seen 1 and 4 weeks later, and after 6 months, normal sized spleens with enlarged vessels in the gastrolienal ligaments were found. When the splenic remnant was left at the main vessels, no obvious growth could be demonstrated after 6 months. The splenic tissue left at the smaller vessels, however, increased in size. Measurements of splenic blood flow in unanesthetized piglets 6 months after operation resulted in greater differences in perfusion per gram among the experimental groups. Not only splenic mass, but also blood flow to the whole splenic tissue seems to be an important factor in the protective function of the spleen.

Animals↗
PubMed1984

[Scintigraphy in chronic micturition disorders].

Partial functions of the kidney, i.e. renal blood flow, GFR etc, can be estimated with radionuclide techniques as safe and non-invasive methods. Many methods have been published to distinguish between obstructive and non-obstructive hydronephrosis. A simple and highly relevant technique is the diuretic radionuclide urography which should be done in all patients with questionable urographic or sonographic findings. The evaluation of split renal function is somewhat difficult because tissue absorption will influence uptake determination. In hydronephrosis this absorption cannot be predicted by sonographic measurement of the kidney's depth and mass. A solutions is to calculate the absorption in these patients by stepwise scintigraphy. Continuous quality control of the technique is emphasized.

Adult↗
PubMed1984

[Cholescintigraphy for determining focal nodular hyperplasia of the liver?].

The preoperative diagnosis of a focal nodular hyperplasia (FNH) is of special interest as in case of non-malignancy of this tumor no extirpation has to be carried out. 86 patients - 19 of them suffered from FNH - have been examined by 3 phasecholescintigraphy. There were no false positive findings (specifity 100 per cent). 2 out of 23 examined FNH were not recognized as such (sensitivity 87 per cent) because the tumor had been changed regressive largely. Cholescintigraphy is an excellent method to prove FNH not bothering the patient too much. Cholescintigraphy should be the first measure of differential diagnostic clarification whenever a benign tumor is suspected.

Adolescent↗
PubMed1984

[Nuclear medicine diagnosis of pulmonary capillary protein leakage].

Pulmonary extravascular albumin extravasation in patients with adult respiratory distress syndrome can be quantified with radionuclide techniques. While imaging procedures with a computerized gamma camera will allow reproducible ROIs, this will be the main limitation in nonimaging measurements with small scintillation probes. Repeated positioning by one operator results in a mean spatial variation of position of about 2 cm and a variation in count rate of 25%. For the estimation of PCPL the small probes must be positioned under scintigraphic control. Under these conditions the results of both techniques are identical. The upper limit of normal was estimated to be 1 x E-5/sec. The standard deviation of abnormal measurements was about 10%. The pulmonary capillary protein leakage can be quantified by radionuclide techniques with good accuracy, using the combination of imaging and nonimaging techniques.

Blood Proteins↗
PubMed1983

Frequencies of segmental perfusion and ventilation abnormalities in lung scintigraphy.

The segmental ventilation-perfusion mismatch is almost invariably a sign of pulmonary embolism (PE). As ventilation scintigraphy is an expensive and time-consuming procedure, it is rarely performed in patients presenting as emergencies. In such patients PE is diagnosed by the presence of a segmental perfusion defect (SPD) in combination with a normal chest X-ray. However, little is known about SPD frequencies in different groups of patients or its value in predicting a mismatch. To determine this frequency, as well as its predictive value for a mismatch (PVM), we examined 764 patients with suspected Pe (PE? group), 359 patients at low risk for PE (low risk group), and 234 patients without suspected PE but at high risk for PE (high risk group), all by perfusion and ventilation scintigraphy. Frequencies of SPD were determined in each group as a function of age. PVM was calculated for each age subgroup using Bayes' theorem. In the low risk group the frequency of segmental mismatches (SM) was about 4%, while one-third of patients at high risk had a SM. This was not age dependent in contrast to the PE? group, where the frequency decreased with age. In the youngest subgroups the PVM for a SPD was higher than 0.9 as well as in a subgroup of the PE? group with a known thrombo-embolic disease. In these subgroups a ventilation scintigraphy is not required for the scintigraphic diagnosis of PE; in all other patients an additional ventilation study is necessary.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

[Scintigraphic image of bile reflux following gastric and intestinal surgery].

Bile reflux may occur after a variety of reconstructive procedures in the gastro-intestinal tract and biliary system. The present paper deals with reflux into the duodenum, jejunum, stomach, oesophagus and into blind loops. The demonstration of reflux by 99mTc labelled IDA acid derivatives, and a possible quantitative approach, are discussed. The advantages of an isotope method are: 1. Direct demonstration of bile reflux without any intervention in the physiological process and with little trouble to the patient, 2. The ability to use the method for various reconstructive procedures and 3. The additional information obtained which may help in the differential diagnosis of blind loops, biliary obstructions, cholecystitis or liver metastases if there has been a gastrectomy for a malignant tumour. In combination with a second administration of a radio-isotope tracer, one may be able to demonstrate abnormalities in the motility of the stomach or gut, or pyloric stenosis or gastro-oesophageal reflux.

Bile Reflux↗
PubMed1983

[Quantitative measurements of regional extra-vascular lung water in dogs using positron emission tomography].

A new method for quantifying regional variations in extravascular lung water (rELW) has been developed. The positron source 15O (T1/2 = 2.0 min.) was provided as H215O 'on line' by constant intravenous injection. Tomographic images (PET) of the water distribution were obtained during equilibrium. The distribution of blood volume was obtained by marking erythrocytes (carboxyhaemoglobin) using a bolus inhalation [C-11)-CO; T1/2 = 20.4 min). Absorption is calculated from transmission tomography. The rELW is defined as: total lung water minus intravascular space. The method was carried out in five intubated and anaesthetised dogs before and after induction of pulmonary oedema with oleic acid (0.06 ml./kg.). Mean ELW (PET) rose from 0.13 +/- 0.02 g./cm.3 to 0.24 +/- 0.04 g./cm.3. There was good correlation with a simultaneously performed thermo-dye method (7.1 +/- 1.3 ml./kg. KG to 13.3 +/- 1.9 ml./kg. KG; r = 0.94). Gravimetric estimations resulted in 13.7 +/- 2.6 ml./kg. KG. The development and distribution of the pulmonary oedema was non-homogeneous and varied regionally.

Animals↗
PubMed1983

Regeneration and function of autologous splenic grafts in pigs.

The growth kinetics, perfusion and immune response of autotransplanted splenic tissue were studied in pigs. Splenic fragments were transplanted subfascially or in the greater omentum and regenerated to small splenules with a normal histologic structure 6 months later. The grafts showed a normal function of the white pulp after antigenic stimulation, and of the red pulp as demonstrated scintigraphically. The blood flow was reduced. The growth kinetic was less rapid than in rodents and resulted in a relatively lower mass of splenic tissue, but these results are closer to findings in human splenosis.

Animals↗
PubMed1983

[Ferrokinetics in 1-dimensional whole-body profiles in hematologic diseases].

Quantitative whole-body linear profile scans of 59Fe, obtained by a whole-body counter, conventional ferrokinetics and hematological parameters are investigated in patients (n = 208) with various hematological-oncological diseases. Linear whole-body profile scans in controls, obtained 24 h after i.v. injection of 59Fe-transferrin, give quantitative information about sites of the erythropoietic system. Early profile scans (1 h p.i.) in patients with anemia show a typical 'iron-suction' corresponding to the fast outflow of 59Fe from the blood compartment. We found no typical change of iron distribution in Hodgkin and Non-Hodgkin lymphomas, even in patients with anemia or hemolysis there was no evidence of expansion of erythropoiesis to distal marrow sites. Our investigation does not contribute to staging of patients with Hodgkin's disease. Osteomyelofibrosis is characterized by a centrifugally expanded erythropoiesis. The value of increased iron uptake 24 h p.i. in leg regions for differential diagnosis of hemolytic anemia, chronic myelocytic leukemia, and pancytopenia where a similar pattern of iron distribution is observed will be discussed. Quantitative iron kinetics with one dimensional 59Fe profile scans give additional information in patients with displaced erythropoietic system.

Erythropoiesis↗
PubMed1982

[Metabolic changes after whole gut washout with an electrolyte solution (author's transl)].

Colonic lavage with physiological saline causes undesirable side effects. A solution as first described by Hewitt was modified and used clinically for whole gut lavage. In comparison with the original solution an unchanged high fluid resorption of 22% of the total was seen. However, changes in acid-base and electrolyte balance were less than after washout with normal saline. Hypokalaemia or metabolic acidosis were not seen any longer. The modified solution thus seems more suitable than saline but does not yet fulfill all the requirements of an optimal solution.

Acid-Base Equilibrium↗
PubMed1982

HLA-B27 in possible ankylosing spondylitis with peripheral arthritis.

Among 86 patients selected as possibly having ankylosing spondylitis because of clinical symptoms and radiologically normal sacroiliac joints. HLA-B27 was positive in 41%. Four years later a representative sample of 38 individuals were re-examined and radiographed. HLA-B27 positive patients developed sacroiliitis as defined by radiological criteria twice as often (P less than 0.05). They also showed increased uptake of technetium 99 m upon quantitative scintigraphy with a region of interest method and more often probable or definite ankylosing spondylitis as defined by the New York criteria. Further differences between the HLA-B27 positive and negative follow-up groups concerned the frequency of clinical symptoms and peripheral arthritis. It is suggested that HLA-B27 typing may be helpful both in diagnosis and in judging the prognosis of possible or abortive ankylosing spondylitis.

Adult↗