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Biomedical subjects

H Courtois

Publications and source records attributed to H Courtois.

At least 145 records · Page 8Linked to original sources
PubMed1985

[Medical treatment of prolactin-secreting pituitary adenomas. Influence of the size of the adenoma].

Forty-two patients with prolactin-secreting pituitary adenoma (prolactinoma) demonstrated by a radiologically abnormal sella turcica and hyperprolactinaemia were treated with bromocriptine. Baseline serum prolactin levels, which before treatment correlated with the size of the adenoma, returned to normal under bromocriptine in 30 out of 36 cases; in 6 female patients, however, they were lowered but remained moderately high. The dose of bromocriptine and the time required for normalization of prolactinaemia correlated with the size of the tumour. In 11 patients with macroadenoma bromocriptine dosage and prolactinaemia were inversely correlated; in 8 of these the adenoma was reduced in size. In 12 cases where the long-term treatment was interrupted, prolactinaemia rose again, suggesting that the medical treatment alone has no lasting curative effect.

Adenoma↗
PubMed1985

[Fasting and postprandial blood glucose in subjects with crural pain and sciatica].

The search for diabetes in a patient with crural neuralgia is well established practice. The prevalence of diabetes in the general population is not known, and studies attempting to demonstrate a relationship between diabetes and radiculopathies have been inconclusive. In the present study, fasting and postprandial blood glucose determinations, as well as 14 other parameters, were analyzed in 88 patients with classical sciatica, 27 with crural neuralgia, and 42 with only back pain. Multidimensional statistical analysis revealed that patients with crural neuralgia were older than those with classical sciatica or only back pain, and that there were no differences in blood glucose regulation. The concept that diabetes is found more frequently in patients with crural neuralgia should be revised, since age appears to be the only factor responsible for changes in glucose regulation.

Adult↗
PubMed1984

[Hematologic repercussions of disorders of thyroid secretion].

The effects on blood of abnormal thyroid hormone secretion were investigated in a prospective study involving 80 patients. Anaemia, when present, could usually be ascribed to association with another pathology. In non-anaemic patients an excess or a deficiency of thyroid hormones had opposite effects on erythrocytes. Leucocytes as a whole were not influenced by hypothyroidism, but untreated hyperthyroidism seemed to be responsible for a relative decrease in the number of neutrophils and a relative increase in the number of eosinophils and mononucleate cells. Platelet counts were unaffected by variations in thyroid hormone levels. Excluding the effects on blood of synthetic antithyroid drugs, the changes observed were generally reversible after correction of the abnormal hormone secretion.

Adult↗
PubMed1984

[Association of familial hyperparathyroidism and Cushing's disease].

Five members of one family had been operated on for primary hyperparathyroidism. One of them also had Cushing's disease (i.e. pituitary tumor). An association between familial hyperparathyroidism and Cushing's disease is quite unusual. Such a combination of rare diseases is not fortuitous though; it probably is but a special type of multiple endocrine neoplasia.

Adult↗
PubMed1981

[Multiple admission to hospital of diabetic patients (author's transl)].

Within an 8 years' period, 29 insulin-dependent diabetic patients were admitted to hospital on more than 5 occasions, which represents 177 admissions for a total of 3407 days. In almost 70% of the cases loss of control of diabetes was the only reason for admission, and in 33% there was no urgency. Diabetes was unquestionably severe in all patients and truly unstable in 6, but socio-economic reasons accounted for at least one admission in 17 patients and for all admissions in 8. The remaining 64 admissions for uncontrolled diabetes were mostly due to the patients' carelessness. Twelve patients totalling 97 admissions never attended the out-patient clinic. Such carelessness seems to have arisen partly from reactive depression and partly from personality disorders, but the physicians's responsibility cannot be dismissed. In order to reduce the number of unnecessary admissions, diabetologists should provide improved patients' training, pay more attention to their psycho-affective problems and demand regular out-patient attendance.

Adult↗
PubMed1981

Blood sugar regulation during treatment with indapamide in hypertensive diabetics.

Eleven insulin-dependent and 30 maturity onset diabetics with essential hypertension were treated with indapamide for 4 and 9 months respectively, to assess its effect on blood sugar regulation. The hypertension responded well to this drug, and fasting and postprandial blood sugar levels did not change significantly. There was no change in the diabetic treatment. Triglycerides, cholesterol and uric acid did not change significantly. Potassium levels fell significantly, but the mean level remained within the normal range.

Adult↗
PubMed1978

[Renal dlabetes and chemical diabetes. Course in young subjects with normal weight (author's transl)].

Ninety-two young patients of normal weight with glycosuria were classified according to the results of glucose tolerance tests into renal diabetes (32 cases) and chemical diabetes (53 cases). After 5 years or more 17 of the patients with renal diabetes were located. In only one case had the development of chemical diabetes led to correction of the initial diagnosis to that of potential diabetes with a reduced renal glucose threshold. Family histories of diabetes were identical in both groups (renal and chemical diabetes) (35 %) and did not provide any means for distinguishing renal diabetes from diabetes mellitus with a reduced renal glucose threshold. Amongst the 34 subjects with chemical diabetes who were located, 3 had become frank diabetics (9 %). Chemical diabetes persisted in 14 patients (42 %) and 17 (50 %) could be considered to be normal. In addition to the three subjects with frank diabetes, only 9 patients (5 with chemical diabetes and 4 normal) continued to take oral therapy at the time of the final examination. However, 13 of these patients who were not taking any treatment had abandoned it relatively recently. Even if the effectiveness of oral therapy is not fully clear, it should be remembered that continued treatment renders the patient less neglectful as far as diet is concerned. Tests for microangiopathy in the three diabetic patients were negative.

Adult↗
PubMed1977

[Outcome in male sterility].

Of a total of 102 cases of male infertility seen over the past ten years, treatment resulted in normalisation of the sperm count in 26, with 12 normal pregnancies resulting. These results concerned cases of oligo-asthenospermia related to a varicocele, pyospermia, hormonal insufficiency or general and psychological disorders. Ten couples were able to have a child with the use of artificial insemination using fresh donor sperm. The abandonment of this technique, nor replaced by the use of frozen sperm provided by a sperm bank, results at the present time in a considerable reduction in the number of inseminations, associated with the overload of these banks. Nevertheless, half of all couples accept the principle of hetero-insemination. The number of couples adopting a child is very low (4% in this study) as a result not only of the difficulties of adoption but also refusal by the couple.

Adoption↗
PubMed1976

[Biological changes in 88 cases of Basedow's disease treated by radioactive iodine].

Biological abnormalities, in particular increased T3 and sometimes TSH, are frequently found in thyrotoxic patients treated with radioactive iodine and subsequently enthyroid. A high T3, associated with an increase in FT4 and a low TSH precedes a relapse. An increase in TSH may indicate progression towards hypothyroidism; even if FT4 and T3 levels are within normal limits. Caution must be exercised before affirming that an increased TSH with a high T3 and normal FT4 is indicative of thyroid equilibrium. At all events, the risk of hypothyroidism despite the use of small doses of radioactive iodine is such that the classical limit for the treatment of patients with thyrotoxicosis should be increased beyond the age of 40. In patients with a high TSH despite being clinically euthyroid, the use of thyroid extract in low dosage (50 mg/day) would appear to be desirable in avoiding the subsequent development of hypothyroidism.

Age Factors↗