Biomedical subjects

H Cottier

Publications and source records attributed to H Cottier.

At least 127 records · Page 7Linked to original sources

PubMed1975

[Immunological aspects of gastrointestinal neoplasms].

The mammalian immune system appears to play an essential role in preventing the development, and/or in controlling growth and spread, of malignant tumor cells. Antigenic properties of neoplastic cells and defense mechanism of the tumor host are briefly reviewed. The relative importance of immune reactions and other "non-specific" means of host defense with regard to tumor development and growth are discussed in the light of available experimental and clinical evidence. An attempt is made to incorporate these considerations into a hypothesis relating to the development of intestinal neoplasms.

Antigens, Neoplasm↗

PubMed1975

Nonspecific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes.

A modified technique was used to demonstrate lymphocytic acid alpha-naphthyl acetate esterase activity in frozen sections of mouse lymphoid tissue or smears. Positive, dot-like reaction products were noticed in more than 94% of the lymphocytes located in the diffuse cortical ("paracortical", "thymus-dependent") area of mesenteric lymph nodes of young adult ICR mice. Almost identical values were found for lymphocytes in the cisterna chyli. In contrast, the follicular cortex which is predominantly occupied by B cells, contained less than 7% esterase-positive lymphocytes. In vitro, cytotoxic anti-theta serum destroyed the vast majority of esterase positive lymphocytes while esterase-negative lymphocytes were resistent to this treatment. In mesenteric nodes of nude BALB/c (nu/nu) mice, follicular cortex and paracortex together contained approximately 16 times less esterase-positive lymphocytes than in the immunologically competent hybrid BALB/c (nu/+) animals. These findings indicate that non-specific acid esterase activity may serve as a criterion to differentiate peripheral T and B lymphocytes in lymph node sections and smears of mice by light microscopy. Possible implications of this enzyme activity in thymus-derived lymphocytes are discussed.

Animals↗

PubMed1975

Thymus lymphocytes. Efflux and restoration phases after peripheral exposure of mice to phytohaemagglutinin.

Juvenile Swiss mice experienced significant diminutions in thymic content of both small, non-proliferating and larger, proliferating lymphocytes within 12 hours after intraperitoneal injection of phytohaemagglutinin. These alterations, which may predate alterations in lymphocyte traffic and morphology elsewhere, were interpreted as being the consequence of a massive thymus lymphocyte emigration, not of in situ cytolysis, and were effaced by intrathymic lymphocyte restoration toward control numbers by 24 hours.

Animals↗

PubMed1975

Physiology of chemotaxis and random motility.

The following aspects of random and directional migration of leukocytes have been considered: (1) basic cellular mechanisms involved in leukocyte locomotion; (2) the mechanisms of formation and the nature of various factors such as cytotaxins, cytotaxin-inactivators and inhibitors participating in the regulation of the chemotactic response, and (3) the relationship between chemotaxis and leukocyte emigration. The need for adequate techniques for measuring chemotaxis has been emphasized with special reference to clinical investigation.

Blood Glucose↗

PubMed1975