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H Coper

Publications and source records attributed to H Coper.

108 records · Page 6Linked to original sources
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An attempt to correlate the development of tolerance to delta-9-tetrahydrocannabinol and d-amphetamine with their subcellular distribution in rat brain.

The daily application in rats of d-amphetamine during 4 weeks in increasing doses from 16-80 mg/kg/day developed a tolerance. The quantitative evaluation of the relative accumulation of unchanged d-amphetamine in different subcellular brain fractions estimated with 3H labelled d-amphetamine showed that the development of tolerance to amphetamine is not associated with a decreased accumulation of the unchanged drug in any subcellular fraction of the brain. Synthetic delta-9-tetrahydrocannabinol (THC) was injected (10 mg/kg) to rats twice daily. After the 9th injection the intensity of the initial depressant effect was approximately similar to that after one injection but completely disappeared after 3 hrs of treatment. The specific activities of delta-9-THC and its metabolites in brain subcellular fractions were estimated with use of 3H-delta-9-THC. The tolerance to delta-9-THC in contrast to amphetamine seems to be mainly metabolic.

Animals↗
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[Sedative-hypnotic compounds in the exhalation of hops, II].

Hops are told to promote sleep; manyfold efforts to detect the soporific principle have been unsuccessful so far. Preliminary pharmacological tests lead to the conclusion that the soporific activity of the exhalation of hops can be explained by its content of 2-methyl-3-butene-2-ol (1) in the volatile fraction. It was found that 1, when given to mice i.p. (0.80 g/kg) produces narcosis for about 8 h; no abnormal behaviour was observed there upon. Due to its water-solubility the concentration of 1 in the essential oil obtained by steam-distillation is low; contrary to that, 1, is enriched in the more volatile fraction of hops.

Animals↗