[Haptoglobin "Marburg"; studies on a rare hereditary haptoglobin variant with 2 different phenotypes in one family].
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Biomedical subjects
Publications and source records attributed to H Cleve.
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A sample from Malawi was studied for the genetic markers haptoglobin (HP), group-specific component (GC) and transferrin (TF). The following allele frequencies were found. For HP: 1F = 0.355, 1S = 0.204, 2FS = 0.396, 2SS = 0.044; the allele 2FF was not observed. For GC: 1F = 0.814, 1S = 0.057, 2 = 0.079, 1A1 = 0.047, 2A1 = 0.0025. For TF: C1 = 0.894, C2 = 0.075, C3 = 0.0026, D1 = 0.029. The HP subtype distribution is among the first to be reported for African blacks.
Two samples representing the Moslem and Christian communities of Jordan were examined for the polymorphic serum proteins AHSG, BF, FXIIIB, GC, HP, PI, PLG, and TF. The results revealed similar allele distributions, and low interpopulation differentiation (GST = 0.0004) between the two communities. The low HP*1S (< 0.12) allele frequencies and the comparatively high PLG*B (> 0.40) and BF*S.07 (approximately equal to 0.05) frequencies are characteristic of the populations of this region.
The allelic distribution of the polymorphic serum proteins AHSG, PLG, FXIIIB and HP was studied in six Jewish groups who migrated to Israel from the Middle East, North Africa, Rumania, Bulgaria, Central and Eastern Europe. The observed AHSG and PLG allele frequencies in these Jewish groups were more or less similar to the observed distributions in non-Jewish populations from their respective areas of origin, while FXIIIB and HP frequencies were similar to those in European populations. Therefore, no uniform pattern of genetic relationships between the Jewish groups was observed. A genetic distance analysis including comparative data from Europe and the Middle East reflected differences between the Jewish groups according to their areas of origin.
A sample of 124 healthy unrelated Arabs from Amman, Jordania were studied for AHSG, BF, F XIII B, GC, PI, PLG and TF serum protein markers. The more recently discovered systems AHSG, F XIII B and PLG appear to be very useful for the characterization of Near Eastern populations.
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