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Biomedical subjects

H Chang

Publications and source records attributed to H Chang.

321 records · Page 18Linked to original sources
PubMedDate not supplied

Nm23-H1 immunohistochemical expression in multisteps of cervical carcinogenesis.

To evaluate the expression of nm23-H1 protein in normal, precancerous, and cancerous tissues of the uterine cervix and its role in cervical carcinogenesis, metastasis and recurrence, 82 cervical specimens, including 30 squamous cell carcinomas (SCC), 19 high- and 13 low-grade squamous intraepithelial lesions (HSILs and LSILs) and 20 normal samples, were stained using immunohistochemical method with streptavidin-biotin peroxidase immunostaining. The Chi-square and Fisher's exact tests, as well as Chi-square test for trend, were used for comparing nm23-H1 expression among normal, LSIL, HSIL, and cancerous tissues. The correlation of nm23 expression with metastasis or recurrence was analyzed using Fisher's exact test. There were significant differences in levels of nm23-H1 expression between LSIL and HSIL (P = 0.016) and between LSIL and SCC (P = 0.004), but not between HSIL and SCC or normal and LSIL samples. Furthermore, a positive relationship was demonstrated for high nm23-H1 protein expression and degree of malignant transformation (P < 0.05). Among the 30 SCC cases, high nm23-H1 expression did not show significant association with either carcinomatous metastasis or recurrence (P = 0.123, 0.372, respectively). High nm23-H1 expression appears related to critical progression of LSIL to HSIL but not to metastasis or recurrence of SCC.

Biomarkers, Tumor↗
PubMedDate not supplied

Prehospital delay and emergency department management of ischemic stroke patients in Taiwan, R.O.C.

OBJECTIVE: To determine the magnitude of prehospital delay and how much time elapses between emergency department (ED) presentation and ED clinical investigations in ischemic stroke patients. Factors associated with prehospital delay were also correlated with demographic characteristics and clinical variables. METHODS: A prospective, observational study was conducted simultaneously in five community teaching hospitals in Taiwan from October 1997 to April 1998. Included were all patients presenting with acute ischemic stroke. In each case, diagnosis was confirmed by cranial CT scanning. The main outcomes measured were the number of patients presenting at the ED more than two hours after the onset of symptoms (T(prehospital) > 2 hr) and the time spent at the ED for ED physician evaluation, cranial CT scanning, laboratory examinations, and neurologic consultation. Chi-square testing was used to compare the characteristics of patients with T(prehospital) > 2 hr and those with T(prehospital)< or = 2 hr. Independent predictors of T(prehospital) > 2 hr were determined using multiple logistic regression. RESULTS: Of 157 patients observed, 105 (67%) arrived at the hospital more than 2 hr after the onset of symptoms. Average time from ED presentation to examination by ED physician, completion of CT scanning, and laboratory investigations was 3, 58, and 61 minutes, respectively. Mean time from ED presentation to neurologic consultation was 174 minutes for 38 patients [24%, (38/157)]. The factor associated with T(prehospital) > 2 hr was interhospital transfer (p < 0.05). CONCLUSION: This study reveals that delayed management of stroke patients is mainly due to delayed ED presentation and to difficulties in obtaining neurologic consultation. Ideally, a stroke center may be incorporated within the EMS system to overcome delays due to interhospital transfer and to difficulties in obtaining neurologic consultation.

Adult↗
PubMedDate not supplied

Use of cardiac troponin T, creatine kinase and its isoform to monitor myocardial injury during radiofrequency ablation for supraventricular tachycardia.

To determine whether radiofrequency ablation for supraventricular tachycardia causes significant minor myocardial injury, 16 patients with supraventricular tachycardia undergoing radiofrequency ablation were studied. Cardiac troponin T, creatine kinase and its MB form (CKMB) were measured before, immediately after ablation and every 6 h thereafter for 24 h to detect myocardial injury. Elevation of creatine kinase, CKMB and cardiac troponin T was observed in 6, 4 and 5 patients, respectively. The peak mean creatine kinase concentration was 167 +/- 152 IU/l and that of CKMB was 9 +/- 6 IU/l. The peak mean cardiac troponin T level was 0.44 +/- 0.47 ng/ml. The frequency of elevated measurements was not statistically different among creatine kinase CKMB and cardiac troponin T. The mean pulse numbers of ablation, mean duration of ablation, radiofrequency current and mean total energy did not differ statistically between those with or without elevated cardiac troponin T. It was concluded that radiofrequency ablation for supraventricular tachycardia indeed caused some minor myocardial injury and the frequency of elevated cardiac troponin T was comparable to that of CKMB.

Adolescent↗
PubMedDate not supplied

Lung abscess in congenital cystic adenomatoid malformation: report of one case.

Congenital cystic adenomatoid malformation (CCAM) of the lung is an uncommon anomaly of fetal development of terminal respiratory structures. Patients with CCAM may present either in the newborn with progressive respiratory distress, or in older children with recurrent pulmonary infections. Lung abscess is an extremely rare presentation. Herein we report an 8-year-old girl with type 1 CCAM who presented as lung abscess.

Child↗
PubMedDate not supplied

Expression of estrogen and progesterone receptors in non-small-cell lung cancer: immunohistochemical study.

Estrogen receptor (ER) and progesterone receptor (PgR) have been recognized as being involved in the tumourigenesis of non-small-cell lung cancer (NSCLC). Forty-nine resected NSCLC (39 males and 10 females) were studied immunohistochemically in formalin-fixed, paraffin-embedded sections for ER and PgR. There were 26 squamous cell carcinomas, 22 adenocarcinomas and one adenosquamous carcinoma. 38.8% (19/49)NSCLC had either a positive ER or PgR status of which one was ER+/PgR+, 2 were ER+/PgR- and 16 were ER-/PgR+. There was no statistical difference in hormone receptors status for sex and histological subtypes (p > 0.05). The immunohistochemical assay of formalin-fixed paraffin-embedded sections allows the retrospective analysis of ER and PgR in NSCLC. The ER-/PgR+ status was detected in about one third NSCLC. The discordance between these receptors is suggested to be due to either the presence of functioning variant ER or the constitutive synthesis of PgR independent of estrogen induction in certain ER-/PgR+ NSCLC.

Adenocarcinoma↗