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Biomedical subjects

H Carstensen

Publications and source records attributed to H Carstensen.

At least 55 records · Page 3Linked to original sources
PubMed1986

Common bile duct obstruction due to an intraluminal mass of candidiasis in a previously healthy child.

A 3 6/12-year-old previously healthy girl had intermittent attacks of abdominal pain following a blunt abdominal trauma. At admission to the hospital, she had jaundice and hepatomegaly. Results of laboratory tests indicated an obstructive pattern, and ultrasonography revealed an intraluminal mass in the distal common bile duct. At surgery, the mass was confirmed as the cause of obstruction, and it was removed. Microscopic analysis indicated that the amorphous material was fungi infested. Growth cultures from bile and feces yielded Candida albicans. Postoperative treatment with T-tube drainage and antimycotic drugs led to an uneventful recovery. Clinical, biochemical, and ultrasonographic follow-up have shown no evidence of recurrence. A possible cause and effect relationship between the trauma and the development of biliary obstruction is suggested.

Abdominal Injuries↗
PubMed1985

A national survey of severe group B streptococcal infections in neonates and young infants in Denmark, 1978-83.

During a six-year period, 1978-83, 80 cases of culture proven group B streptococcal (GBS) bacteraemia and meningitis were identified in neonates and young infants up to 12 weeks of age in a national retrospective survey. Two thirds (68%) were early onset disease (EOD) while one third was late onset disease (LOD) occurring later than the seventh day of life. The overall incidence for the period was 0.24 per 1,000 live-born with a trend towards decline through the period. EOD was associated with low birthweight, twin delivery and congenital anomalies as well as with obstetric risk factors like premature or prolonged rupture of membranes and intrapartum fever. The overall case fatality rate was 23%, both in EOD and LOD. Seven (11%) of the surviving infants, six of whom had had meningitis, developed neurological sequelae. Newborns that showed signs of infection with 12 hours of delivery were at a significantly higher risk of running a fulminant course than newborns whose infections developed later (p = 0.02). Nosocomial transmission of GBS seemed limited and most hospital-acquired cases were unconnected.

Age Factors↗
PubMed1982

Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature.

A mathematical model for the calculation of free and protein bound concentrations of testosterone and estradiol in plasma is presented. The method is based on the knowledge of the total concentrations of all steroids competing for the same binding site on testosterone-estradiol-binding globulin (TeBG), the concentration of albumin, the binding capacity of TeBG, and the association constants of the steroids to the two binding proteins. For the calculations we have determined the total concentrations of testosterone and estradiol. TeBG binding capacity, albumin concentration and the association constants for the binding of testosterone, estradiol and 5 alpha-dihydrotestosterone (DHT) to TeBG and albumin at 37 degrees C. Physiological concentrations of some androgen metabolites reported in the literature were also included in the calculations, namely: DHT, 5-androstene-3 beta, 17 beta-diol (Ae) and 5 alpha-androstane-3 alpha, 17 beta-diol (Aa). The binding constants for Ae and Aa to TeBG and albumin were also from the literature. Mean values of testosterone were calculated for 11 normal men and expressed as percentages of total: 2.0% was unbound, 53--55% bound to albumin and 43--45% bound to TeBG. For 16 normal women of a fertile age the corresponding values were 1.5%, 36--37% and 62%. For estradiol they were 2.4% 68--70% and 28--30% in the men and 2.0%, 52% and 45--46% in the women. Variations in the concentrations of DHT. Ae and Aa did not influence the free concentrations of testosterone and estradiol to any significant extent. It was furthermore concluded that the androgen metabolites could be omitted from the calculations without affecting the calculated concentrations.

Adult↗