Urinary tract infection and antibiotic susceptibility in malnourished children.
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Anti-Bacterial Agents↗
Biomedical subjects
H Caksen
Publications and source records attributed to H Caksen.
A case of Adams-Oliver syndrome associated with acrania, microcephaly, hemiplegia, epilepsy, and mental retardation.
Adams-Oliver syndrome (AOS) is a rare congenital disorder, characterized by aplasia cutis congenita (ACC) of the scalp and variable degrees of terminal transverse limb defects. In this article, a newborn infant diagnosed as AOS for a large scalp defect, acrania, and finger malformations is presented. The patient was hospitalized and the scalp defect was successfully repaired with several surgical operations. During the hospitalization septicemia, meningitis, and convulsions developed, but they were successfully treated with appropriate antibiotics, antifungal, and anticonvulsive agents, He was discharged five months after admission to the hospital. Now, he is 3 years old, and has microcephaly, moderate mental retardation, left spastic hemiplegia, and epilepsy.
Abnormalities, Multiple↗
Splenic abscess, pleural effusion and severe anemia caused by Salmonella typhi.
Various complications related to gastrointestinal system, central nervous system, and skeletal system may be observed during typhoid fever, but splenic abscess and pleural effusion are rarely encountered. A 12-year-old boy was admitted with fever, fatigue and pallor. On examination he had hepatosplenomegaly and severe anemia. He was diagnosed as having Salmonella typhi infection complicating with splenic abscess, pleural effusion and severe anemia, and successfully treated with percutaneous drainage with ultrasonography and antibiotics. In conclusion we would like to emphasize that typhoid fever should also be considered in patients with hepatosplenomegaly and severe anemia, and percutaneous drainage with ultrasonography may successfully be used in management of splenic abscess in typhoid fever.
Abscess↗
Budd-Chiari syndrome in a patient heterozygous for both factor V Leiden and the G20210A mutation on the prothrombin gene.
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Budd-Chiari Syndrome↗
A review of 207 newborn with tetanus.
In this study, 207 patients with neonatal tetanus admitted to Erciyes University, Faculty of Medicine, Unit of Neonatology between 1976 and 1994 were investigated retrospectively. One hundred and sixty-seven (80.6%) patients had non-hygienic home deliveries and none of the mothers of the children had been immunised with tetanus toxoid. Of the 207 patients, 161 (77.8%) were males, 46 (22.2%) were females. Failure to suck and twitching were the most frequent symptoms. The mean age of patients who died or survived was 6.9 and 8.8 days respectively (p > 0.05). Mean birth weight was 3092 g for the fatal cases and 3317 g for the survivors (p < 0.05). Mean age of onset of symptoms was 5.5 days for the fatal cases and 6.5 days for the survivors (p < 0.05). Mean period between onset of symptoms and hospital admission was 1.5 days for the fatal cases and 2.1 days for the survivors (p > 0.05). Ninety-seven (46.8%) of the 207 patients died. Mean age of death was 9.3 days and most of the patients died at the fifth day of admission to hospital. Sex, age on admission and duration of symptoms did not affect the prognosis. In addition, the efficacy of the diazepam, phenobarbital sodium and chlorpromazine used for sedation in neonatal tetanus was investigated. Of 207 patients, 43 patients were treated with diazepam, 33 patients with phenobarbital sodium, another 33 patients with phenobarbital sodium + chlorpromazine and 94 patients were treated with diazepam + phenobarbital sodium +/- chlorpromazine called as "combined therapy". The least mortality rate was found in the group treated with "combined therapy" and the highest mortality rate in the group treated with phenobarbital sodium + chlorpromazine (p < 0.001). The most frequent cause of death was apnea in the first week and sepsis in the later period.
Cause of Death↗
Neuroblastoma and Poland syndrome in a 15-year-old boy.
A 15-year-old boy with neuroblastoma associated with Poland syndrome is presented. He was admitted with a 2-month history of progressive back pain and a 3-day history of weakness of the lower extremities, encopresis and enuresis. On physical examination, in addition to paraplegia, absence of the pectoralis major muscle was diagnosed on the right side of his chest. A large heterogeneous mass in the right side of the thorax was revealed on computerized tomography. Neuroblastoma was diagnosed on histopathological analysis of the mass. To the authors' knowledge this is the first case of neuroblastoma associated with Poland syndrome in the literature.
Adolescent↗
Aarskog syndrome associated with hypermetropia and toe anomaly.
Aarskog syndrome is characterised by a disproportionately short stature and facial, skeletal and urogenital anomalies ('shawl' scrotum and cryptorchidism). Ophthalmic findings include a slight downward slant to the palpebral fissures, hypertelorism, blepharoptosis, strabismus, ophthalmoplegia, hypermetropic astigmatism and a large cornea. Findings on the extremities include joint hyperextensibility, short and broad hands, interdigital webbing, a short fifth finger, clinodactyly and broad feet with bulbous toes. We report on a 7 1/2-year-old boy with typical findings of Aarskog syndrome, hypermetropia and bilateral proximal implantation of the fifth toes. These associated abnormalities have hitherto never been described, to our knowledge.
Abnormalities, Multiple↗
A case of the cardiofacial syndrome (Cayler's syndrome).
An infant whose face appears asymmetrical at rest and whose mouth is pulled downward to one side when crying is said to have an 'asymmetric crying facies' (ACF). The association of ACF with congenital cardiac anomalies is known as cardiofacial syndrome (Cayler's syndrome). The present report describes a case with cardiofacial syndrome and ACF associated other congenital anomalies, and provides criteria for differentiating absence of the depressor anguli oris muscle (DAOM) from palsy of the seventh cranial nerve and its central connections.
Crying↗
Imaging of an atypical case of congenital toxoplasmosis.
In this article we describe the cranial computerized tomography findings of an infant with congenital toxoplasmosis, which was performed because she showed an atypical clinical course consisting of meningitis and multiple cerebral abscesses. In this case the cranial computerized tomography allowed the diagnosis of hydrocephalus and multiple cerebral abscesses, and guided the therapeutic approach.
Brain Abscess↗
A case of malignant histiocytosis associated with skin involvement mimicking kwashiorkor.
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Child, Preschool↗
Perioral skin and mucosal lesions due to chloral hydrate.
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Chloral Hydrate↗
The effects of prednisolone and serum malondialdehyde levels in puppies with experimentally induced meconium aspiration syndrome.
The aim of this study was to investigate the effect of different doses of prednisolone in puppies experimentally induced with meconium aspiration syndrome (MAS). Meconium was collected from human babies in the first day of life and was released into the trachea of 11 newborn puppies to induce MAS. Puppies were treated with 2 mg/kg prednisolone (standard dose), 30 mg/kg prednisolone (megadose) or 0.9% saline, all administered intravenously. The study ended 20 h after meconium aspiration and the lungs were then scored for histopathology. Animals not treated with prednisolone deteriorated after 8 h while respiration rate, oxygenation, pH and partial pressure of carbon dioxide values were better in the prednisolone-treated groups. Histopathology scores were better in the treatment groups compared with the control group, with megadose giving the best result. At the end of the study, serum malondialdehyde levels were significantly higher in the megadose prednisolone group compared with the other two groups. In conclusion, we determined that prednisolone reduced physiological and histological changes in puppies with MAS and that a 30 mg/kg dose was more effective than 2 mg/kg.
Animals↗
Gliclazide-induced hepatitis, hemiplegia and dysphasia in a suicide attempt.
The drugs used to treat diabetes mellitus are diverse and include several classes. One class is sulfonylureas which primarily cause serum glucose reduction by stimulating the release of preformed insulin from the pancreatic islets. Gliclazide, a second generation sulfonylurea, is used to control glycemic levels in non-insulin-dependent diabetes mellitus. We report a 14 year-old non-diabetic girl who developed hepatitis, hemiplegia and dysphasia after ingestion of an overdose of gliclazide (20 mg/kg/day) in a suicide attempt. Our purpose is to draw attention to the severity of gliclazide-induced neurological signs. To the best of our knowledge, gliclazide-induced hemiplegia and dysphasia have not been previously reported in the literature.
Adolescent↗
Asymmetric crying facies and congenital hypothyroidism: report of two patients.
A congenital asymmetric crying facies (ACT) is caused by congenital hypoplasia or agenesis of the depressor anguli oris muscle. Associations of this facial defect with major congenital anomalies have been reported, most commonly in the cardiovascular system and less frequently involving the genitourinary, musculoskeletal, cervicofacial, respiratory, and rarely, the endocrine system. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac defects. Two newborn infants who had ACF associated with congenital heart defect and congenital hypothyroidism are described. To the best of our knowledge the association of ACF and congenital hypothyroidism has not previously been published.
Congenital Hypothyroidism↗
Persistent neonatal hypoglycemia: an unusual finding of congenital hypothyroidism.
We report a newborn infant who has congenital hypothyroidism associated with profound and persistent neonatal hypoglycemia. Persistent and marked hypoglycemia has not been previously reported in congenital hypothyroidism to our knowledge. The cause of this condition may be reduced glyconeogenesis or insulin clearance.
Congenital Hypothyroidism↗
Collodion baby concomitant with congenital hypothyroidism: a patient report and review of the literature.
Collodion baby is a rare congenital disorder resembling harlequin fetus but is milder in degree. Although it has been reported that harlequin fetus is associated with kidney abnormalities, malignant keratoma, micromelia, polydactyly, thymic atrophy and thyroid aplasia, there are few reports of collodion baby associated with congenital abnormality and/or disease in the literature. A newborn infant admitted with shedding of the skin and diagnosed as collodion baby concomitant with congenital hypothyroidism is presented here. This is the first case of collodion baby associated with congenital hypothyroidism in the literature to our knowledge.
Abnormalities, Multiple↗
Thyroid function tests in the newborn infants of preeclamptic women.
The purpose of this study was to identify possible changes in thyroid functions in newborn infants of preeclamptic women. Fifteen neonates (nine boys and six girls) of preeclamptic women and 17 healthy neonates (nine boys and eight girls) for the control group were included in the study. Serum thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and total thyroxine (TT4) levels and thyroid gland volumes were determined in both groups. Serum TSH and TT4 levels were not statistically different between the two groups. However, serum TT3 level was 79.22 +/- 40.19 ng/dl in the study group and 40.00 +/- 15.99 ng/dl in control subjects (p < 0.01). The mean right, left and total thyroid volumes were 1.3 +/- 1.2 ml, 1.2 +/- 1.1 ml and 2.4 +/- 2.3 ml in the study group and 0.6 +/- 0.2 ml, 0.6 +/- 0.2 ml, and 1.1 +/- 0.4 ml in the control group, respectively (p < 0.05). The mean thyroid volume/body weight was 0.9 +/- 0.09 ml/kg in the study group and 0.3 +/- 0.06 ml/kg in the control group (p < 0.05). In conclusion, we would like to stress that preeclampsia might be a cause of fetal and neonatal thyroid enlargement and elevated serum TT3 level.
Female↗