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Biomedical subjects

H C Williams

Publications and source records attributed to H C Williams.

143 records · Page 8Linked to original sources

Vascular thrombosis in acute hepatic allograft rejection: scintigraphic appearance.

Hepatobiliary imaging with 99mTc diisopropyl iminodiacetic acid was employed serially in a patient with an hepatic allograft, in order to follow the function of the transplant. Initially improving liver uptake and biliary excretion was observed; however, 12 days postoperative with clinical deterioration the scintigrams revealed an absence of uptake ("phantom" liver), due to thrombosis of the hepatic artery related to acute rejection. Hepatobiliary imaging can be helpful in the study of hepatic allografts.

Biliary Tract↗

Posttraumatic acalculous cholecystitis.

Acalculous cholecystitis occurred in six patients after trauma and burns. The majority developed signs and symptoms similar to acute calculous cholecystitis. All were treated by cholecystectomy after traditional conservative treatment failed. All had either gangrenous changes or focal necrosis of the gallbladder. Postoperative recovery was uniform. Acalculous cholecystitis occurs in 0.5% of large series of injured or burned patients. Delayed recognition led to a high mortality, reported as 24% overall with 10% related to gallbladder disease. Although cholecystostomy has been advocated, it appears that cholecystectomy, when feasible, affords the best overall results.

Adult↗

Patterns of morbidity and mortality in splenic trauma.

The cases of 337 consecutive patients undergoing splenectomy for trauma have been reviewed. The combination of physical examination and peritoneal lavage is effective and safe in establishing the need for operation. Associated injuries are the major determinants of mortality. Exsanguination, infection, and neurologic injuries are the major causes of death.

Female↗

Detection of intracolonic lesion by barium contrast enema. The importance of adequate colon preparation to diagnostic accuracy.

Frequently, the clinical significance of the barium contrast enema is minimal because of inadequate colon preparation prior to examination. The frequency of false-positive routine barium enemas was 17% in 230 consecutive patients who underwent colonoscopy for removal of specific radiographically identified polypoid colon lesions. Initial barium enema inaccuracies were documented with postendoscopic air-contrast radiography in colons that were endoscopically proved to be mechanically clean following a two-day colon preparation. These results suggest that more emphasis on a two-day colon preparation, before the initial barium contrast enema, would substantially reduce the frequency of false-positive interpretations.

Barium Sulfate↗

Hepatic changes in young women ingesting contraceptive steroids. Hepatic hemorrhage and primary hepatic tumors.

Primary hepatic tumors developed in 13 young women who had been ingesting contraceptive steroids. Nine tumors were benign, and four malignant. Six tumors ruptured spontaneously and caused life-threatening hemorrhage. Benign tumors were successfully resected in eight women. One woman died during hepatic resection for malignant hepatoma; in two other cases of hepatocellular carcinoma, tumors were nonresectable. In two patients, the tumor was left in situ after neoplasm had been excluded by biopsy. The increase of such tumors in women of childbearing age warrants the suspicion that these contraceptive steroid hormones play an etiologic role.

Adult↗

Fish tank granuloma in a 14-month-old girl.

A 14-month-old girl developed a persistent ulcerated nodule on her right lower leg associated with further nodules along the thigh. A clinical diagnosis of fish tank granuloma was suspected because of tropical fish tanks at home. The diagnosis was confirmed when Mycobacterium marinum was isolated from low-temperature culture of skin tissue. The child made a complete recovery following treatment with rifampicin for 6 months despite in vitro sensitivity tests reporting resistance. M. marinum infection is uncommon in children, but the diagnosis should be considered in children presenting with chronic skin lesions spreading in a sporotrichoid pattern.

Animals↗