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Biomedical subjects

H C Peng

Publications and source records attributed to H C Peng.

44 records · Page 3Linked to original sources
PubMed1990

[Surgical treatment of esophageal atresia--6 years of experience].

Surgical treatment of fourteen infants with esophageal atresia over the past six years was reviewed retrospectively. Two patients had esophageal atresia without tracheoesophageal fistula (Gross Type A), the other 12 patients had distal tracheoesophageal fistula (Gross Type C). Associated anomalies were found in three patients: one had a patent ductus arterious, another had trisomy 18, and the third had polydactylia. According to Waterston's risk group classification, there were 7 cases in Group A, 5 in Group B and 2 in Group C. The choice of operative method mainly depended on the distance between the two esophageal ends. Two patients with Type A atresia were treated by a staged operation because the distance between the two esophageal blind ends far exceeds 2 cm. A Type C patient with a "gap" longer than 2 cm who first had his esophagostomy, gastrostomy and ligation of the tracheoesophageal fistula at another hospital was transferred to us to get an esophageal reconstruction using a right-side ileocolon. Another ten Type C patients with a "gap" of less than 2 cm were operated on by extrapleural end-to-end esophago-esophagostomy after their tracheo-esophageal fistula was closed. The remaining Type C patient with a longer gap of about 3 cm was treated by primary anastomosis following mobilization of the upper pouch as well as limited mobilization of the lower esophageal segment. Anastomotic leakage was found in three patients. One patient developed subsequent stricture when the leakage was healed. The causes of mortality in three patients were pulmonary hemorrhage, sepsis and pneumonia respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Esophageal Atresia↗
PubMed1989

Edema-producing proteins isolated from Trimeresurus mucrosquamatus snake venom.

Seven edema-producing fractions were isolated from Trimeresurus mucrosquamatus snake venom by CM-Sephadex C-50 chromatography and further purified by gel filtration on a Sephadex G-75 column. They were homogeneous as judged by electrophoresis on polyacrylamide gels. The mol. wts were estimated to be 26,900 (Fr. IV-2), 21,500 (Fr. X-2), 23,000 (Fr. XII-2), 21,800 (Fr. XIII-2), 24,600 (Fr. XIV-2), 80,000 (Fr. XVIII-1) and 22,500 (Fr. XXII-2). Fraction IV-2 had weak esterase activity, fractions X-2, XII-2, XIII-2 and XIV-2 possessed proteolytic activity toward casein and fibrinogen, while fractions XVIII-1 and XXII-2 possessed phospholipase A2 activity. Fractions with phospholipase A2 activity had greater edema-producing activity than those with protease and/or esterase activity. It is concluded that the edema caused by T. mucrosquamatus venom may be due to phospholipases A2, proteases and esterases.

Amino Acids↗
PubMed1988

Reappraisal of atrioventricular junctional pacemaker automaticity in the sick sinus syndrome. Clinical significance and the role of autonomic chronotropic influences.

Postpacing impulse recovery times of the junctional tissue (junctional automaticity) were determined by atrial or ventricular overdrive pacing in 27 patients with dysfunction of the sinus node. The maximum junctional recovery time (MJRT) could be measured in 22 patients and ranged from 1,630 to 9,730 ms (mean 3,860 +/- 2,077); the maximum corrected junctional recovery time (MJRTc) could be measured in 18 patients and ranged from 140 to 5,986 ms (mean 2,089 +/- 1,529). Autonomic influence on the JRTs was evaluated by intravenous administration of atropine (1.5 mg) alone or in combination with propranolol (5 to 6 mg). Of the seven patients in whom MJRTc and/or MJRT could be measured before and after drug intervention, the JRTs shortened in four and prolonged in three after combination of atropine and propranolol. Atropine alone shortened MJRT in all eight patients studied. Our data reveal that both vagal and catecholamine-dependent factors (especially vagal over-activity) are operative in the escape mechanism of the junctional tissue.

Adult↗
PubMedDate not supplied

[Appendicitis in children: clinical observation in 88 surgical cases].

From February 1983 to December 1987, appendectomy was done in 106 children for the presumptive diagnosis of appendicitis with or without perforation at VGH-Taichung. Subsequent pathological findings confirmed suppurative appendicitis in 53 patients (48.1%), and perforated appendicitis in 37 patients (34.9%). There were 18 (17.0%) normal appendices. The age of patients ranged from 2 to 14 years, with an average of 8.9 years. Only 9.1% of the patients were under 5 years of age. The perforation rate was 62.5% in children under 5 years of age, and 59.4% in children 5 to 8 years old, both of them had a higher incidence than children over 8 years of age (27.1%, P less than 0.05). The mean duration of symptoms was 76.2 hours in children with perforated appendicitis, which was significantly longer than that in children with suppurative appendicitis (28.7 hrs, P less than 0.05). The use of triple combination of antibiotics in the treatment of perforated appendicitis has been proved to significantly decrease the incidence of postoperative wound complications. Early diagnosis, prompt surgical intervention, and recognition and treatment of residual septic foci were proved appropriate means of treatment of appendicitis.

Adolescent↗
PubMedDate not supplied

Neonatal Staphylococcus aureus pancarditis: report of one case.

Due to poor feeding, decreased activity and severe abdominal distension, a 20-day old female infant was admitted to our hospital. The patient was diagnosed as having necrotizing enterocolitis and received a multiple segmental resection. During the hospitalization, recurrent sepsis and candidiasis occurred. On the 56th day of admission, tachycardia, thrombocytopenia and cardiomegaly were noted. Sudden onset of cardiac arrest occurred and a post-mortem examination revealed staphylococcal pancarditis. Pancarditis is a rare and fatal disease in newborns. When a patient with a catheter insertion shows unknown cause of thrombocytopenia and acute onset of cardiomegaly, an echocardiogram is highly suggested. Early diagnosis and proper parenteral antibiotics may be life-saving.

Acute Disease↗