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Biomedical subjects

H C Miller

Publications and source records attributed to H C Miller.

At least 73 records · Page 4Linked to original sources
PubMed1983

Peyronie disease treated with ultrasound and hydrocortisone.

Thirty patients with Peyronie disease were treated with ultrasound using hydrocortisone ointment as the conducting vehicle. Twenty-five patients completed at least one course of treatment. Of those 25, 19 had at least some benefit with evidence that multiple courses of treatment were more beneficial than a single course. We conclude that ultrasound with hydrocortisone is beneficial in relieving pain, relieving deviation, and reducing the size of the fibrous plaque. It has the advantages of being noninvasive, repeatable, and without any side effects.

Administration, Topical↗
PubMed1983

Factors associated with infections among breast-fed babies and babies fed proprietary milks.

Correlation of first postnatal year infections among 251 babies was made with the infant feeding mode, socioeconomic status of family, maternal educational level, age, and maternal behavioral factors including smoking habit and number of siblings in the family. Initially, 127 mothers intended to breast-feed and 124 intended to formula-feed their infants. In the correlation matrix maternal education was the highest variable inversely correlated with infection; it was the first to enter in stepwise regression analysis and was highly significant (P less than .0001). Maternal weight gain during pregnancy and infant feeding mode were the next two variables, respectively, to be added during the stepwise regression but they were not significant in the presence of maternal education. The statistical significance of increased maternal education in inverse relation to infection persisted in the presence of the other two factors (P less than .0064). The t test showed no significant difference in the number of infections among the breast-fed and formula-fed babies within any of the three maternal education groups. It may be concluded that in the population studied, the infant feeding mode itself was not significantly related to the number of infections during the infant's first postnatal year when the education of the mother was taken into account.

Adult↗
PubMed1982

Bioavailability, distribution and pharmacokinetics of diethystilbestrol produced from stilphostrol.

The kinetic behavior of diethylstilbestrol (DES) produced from stilphostrol has been studied in man, dog and rat. A sensitive and selective assay for DES in plasma and tissues has been developed with the use of gas chromatographic separation and mass spectrometric detection. In patients with prostate cancer, the plasma concentrations of DES produced by 1,000-mg. infusions of stilphostrol are 1,500 times the DES concentrations produced by conventional oral DES doses. The pharmacokinetics of DES show 2 separate phases; 1 with a t1/2 of approximately 1 hour, another with a t1/2 of approximately a day. In rats, stilphostrol does not selectively liberate DES in the prostate compared to dosing with DES itself. In dogs, a 50-mg. tablet of stilphostrol was bioequivalent to 40 mg. of DES taken orally. Some of these data support the idea that the high DES concentrations produced by stilphostrol infusions underlie in its ability to produce objective responses in patients refractory to conventional oral DES therapy.

Animals↗
PubMed1982

Persistence of ductus arteriosus with left to right shunt in the older patient.

Eight hundred and four patients with persistence of the ductus arteriosus were seen in Edinburgh between 1940 and 1979. Thirty-seven of them reached the age of 50 years, and in 32 the shunt was exclusively from left to right. Fifteen of the 32 were subsequently treated surgically. None of the 32 was lost to follow-up. Duration of clinical observation averaged 17 years and extended to over 30 years in eight patients. Their features have been correlated with those from reports of 48 comparable patients in an attempt to clarify the management of the persistent ductus in the older patient. Impairment of left ventricular function is shown as the major risk, even when the ductus is small. Bacterial endarteritis is infrequent. Surgical treatment carries greater risk than in childhood and early adult life but usually reduces heart size and restores exercise tolerance. Left ventricular dysfunction, however, occasionally vitiates the benefits; symptoms are then incompletely relieved and death from heart failure may occur months or years after operation. Experience in older patients thus emphasises the value of elective operation in childhood, however well the child, however trivial the shunt. It is concluded that in older patients, the presence or the development of symptoms or cardiac enlargement are almost always indications for surgical treatment. As age increases, especially by the eighth decade, medical treatment may be preferable. Continued follow-up of symptomless patients without cardiomegaly is important because increase in heart size usually precedes further deterioration which can then be prevented by timely surgical treatment.

Adult↗
PubMed1981

Somatic growth failure in infants related to artifact and error.

Growth failure in infants may be diagnosed erroneously because of artifact, error, or both. Assuming that all full-term infants have the same gestational age creates an artifact that is confounded further by errors in measurement of birth length. Crown-heel lengths of 77 while full-term newborns born at the University of Kansas Medical Center, Kansas City, were plotted on standard National Center for Health Statistics postnatal growth chart percentiles appropriate for sex, both with and without regard for gestational age. By the end of the first postnatal year, significantly fewer downward shifts in the growth curves occurred when fetal age was considered in the location of birth percentiles, according to tables by Miller and Merritt. To avoid confusion in interpretation of downward shifts in infants' growth patterns, we recommend that accurate crown-heel lengths be obtained at birth and plotted according to gestational age whenever possible.

Body Height↗
PubMed1981

Intrauterine growth retardation. An unmet challenge.

Most standards of fetal growth are grossly inadequate. Standards of fetal growth should be revised so that they represent normally grown fetuses and newborn infants; their data should be displayed in a uniform manner, and proper allowances should be made for intrinsic factors that affect fetal size significantly, namely gestational age, ethnic group, sex of infant, and maternal parity, height, and weight. The pathogenesis, consequences, and incidence of intrauterine growth retardation (IGR) will not be clearly understood until the different types of IGR are more widely recognized than at present. The incidence of IGR was observed to be significantly higher when the specific types of IGR were diagnosed rather than relying on low birth weight for gestational age, which does not distinguish between the different types of IGR.

Birth Weight↗
PubMed1981

Atrial fibrillation and isolated suppression of the pituitary-thyroid axis: response to specific antithyroid therapy.

Four patients are described with persistent atrial fibrillation associated with normal plasma total thyroxine (T4) and triiodothyronine (T3) but an absent plasma thyrotrophin (TSH) response to intravenous thyrotrophin releasing hormone (TRH). Initial cardioversion failed to establish sinus rhythm in three of the four patients. Following specific antithyroid therapy to lower thyroid hormone levels sufficient to allow a normal TSH response to TRH sinus rhythm was established in all four patients, one spontaneously and three after cardioversion. Stable sinus rhythm has persisted in three patients over a 2-yr follow-up period. In the presence of atrial fibrillation, an absent plasma TSH response to TRH should be considered sufficient grounds for antithyroid therapy even if plasma total T4 and T3 are within the expected normal range.

Atrial Fibrillation↗
PubMed1980

Antigen induced modulation by shed lymphocyte membrane gangliosides.

A unique regulatory mechanism has been proposed for ganglioside which functions to immune responses to temporarily restrain B lymphocytes of all specificities and at various levels of differentiation. Utilizing antigen competition protocols, experiments was designed to exploit and extend the antigen induction properties of this modulation. Spleen cell cultures were prepared from TNP-BGG primed mice. In vitro stimulation of the cultures with ovalbumin (OVA) followed 24 hours later by addition of TNP-BGG resulted in only one weak TNP hemolytic plaque responses when compared to control cultures which did not receive OVA. OVA induced competitive effects were absorbed by anti-Thy-1 or anti-ganglioside. Glycolipids could be extracted from the culture media supernatants of experimental and control groups as a ganglioside fraction containing Thy-1 determinants. These molecules, when formulated into liposomes, produced the same modulatory effect as that of media from the competitive culture group. These results support and extend the proposal that glycolipids released by antigen stimulated T cells provide unrestricted modulation of B cells to prevent overload during T cell maturation. This regulatory mechanism prevents direct antigen binding and prepares B cell receptivity for further stimuli which orchestrate their terminal differentiation into plasma cells.

Animals↗
PubMed1980

Selective removal of T cell function from mouse lymphocyte suspensions by treatment with normal guinea pig serum.

Treatment of murine spleen cells with normal guinea pig serum selectively abrogated responsiveness of these cells to the T cell mitogens PHA or Con A, but failed to affect responses to LPS, i.e., a B cell-specific mitogen. Although pretreatment with GPS inhibited the in vitro immune response of mouse splenocytes to SRBC, responses were normal after restoration with T cells only, indicating that B cells had been spared by GPS. Consistent with these results, incubation with GPS resulted in the loss of reactivity of mouse lymphoid cells in MLC as well as CML systems, both of which test for T cell activities. Furthermore, parental spleen cells treated with GPS were no longer capable of inducing a GVH reaction in F1 hybrids. When compared, the effects of GPS and anti-Thy-1.2 antibodies plus C were found to be comparable. These results indicate that GPS can selectively remove a number of T cell functions from heterogeneous murine lymphoid cell suspensions. Since spleen macrophages were insensitive to GPS cytotoxicity, lack of T cell function is not likely to be due to depletion of these accessory cells.

Animals↗