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Biomedical subjects

H C Korting

Publications and source records attributed to H C Korting.

At least 235 records · Page 13Linked to original sources
PubMed1984

[Cephalosporin allergy and cephalosporin-penicillin cross allergies with special reference to venereologic therapy of severe anaphylactic reactions].

The newer cephalosporins are gaining more and more importance in antimicrobial chemotherapy. This also applies to venereology. Yet before widespread use, their potential for anaphylactic reactions must be defined, as they are not uncommon with penicillin. In fact, the first cephalosporins shared this drawback with penicillin. According to the experimental and clinical data available, the newer cephalosporins, however, should not give rise to severe allergic reactions of the immediate type. This at least holds true for individuals without a history of allergy to beta-lactam-antibiotics but, in fact, not even they should be endangered. This, however, still needs further confirmation.

Anaphylaxis↗
PubMed1983

Distribution of auxotypes and correlation to antibiotic susceptibility of 169 recent clinical Neisseria gonorrhoeae isolates from Munich.

In Munich 169 isolates of Neisseria gonorrhoeae were investigated with respect to nutritional profiles (auxotypes) and antibiotic susceptibility. Of the 165 penicillin-susceptible strains 97 proved to be prototrophic (auxotype 1), 42 proline-dependent (auxotype 2). Only 3 arginine-, hypoxanthine- and uracil-dependent strains (auxotype 14) were found. A total of 10 different auxotypes were identified among the non-penicillinase-producing strains and one among the penicillinase producers. The minimal inhibitory concentrations of penicillin G ranged from 0.01 to 1 microgram/ml, those of cefuroxime from 0.001 to 4 mg/ml; tetracycline and kanamycin had a narrow spectrum of effective concentrations, from 0.25 to 8 micrograms/ml and from 4 to 64 micrograms/ml respectively. The type 14 strains showed the well-known high susceptibility to penicillin G.

Cefuroxime↗
PubMed1983

Cultural proof of Neisseria gonorrhoeae in synovial fluid in disseminated gonococcal infection.

Disseminated gonococcal infection is not too rare, and joint involvement is one of its prominent features. Although diagnosis in general is based on clinical findings and microbiological examination of the genitals and sometimes blood, there are cases in which exact diagnosis can only be made after the investigation of synovial effusion. An observation of this kind is presented, and the general value of the aspiration of synovial fluid in disseminated gonococcal infection is discussed. Special interest is also given to the possible coincidence of disseminated gonococcal infection and other sexually transmitted diseases as for example trichomoniasis, both of which were found in our case.

Adult↗
PubMed1983

[Metronidazole therapy of rosacea. The drug and its indications].

Introduced on the basis of a primary incidental observation metronidazole has gained more and more interest in the treatment of rosacea. Even before its list of indications had widened steadily. First being used for trichomoniasis, metronidazole is now administered in diseased states as different as anaerobic infection and dependence on alcohol. Although even prolonged administration so far has caused on the whole only minor side-effects in man the experience gained in experimental animals fuels doubts with respect to its long-term safety. Although metronidazole therapy for rosacea proved effective we propose to confine its use to cases that do not respond to tetracycline or local treatment. Pregnancy should be considered a contraindication.

Biotransformation↗
PubMed1983

[Determination of pathogens in blood in disseminated gonococcal infection. Case report and overview of the literature].

Although Neisseria gonorrhoeae has been recognized as causative agent of infectious disease not only of the genital region but also of other organs already at the end of the 19th century, disseminated gonococcal infection as a clinical entity has been defined fairly recently, i.e., during the last decade. In particular, it has been very difficult for a long time to detect Neisseria gonorrhoeae in the blood of patients suffering from this form of gonorrhea. Therefore, the case of a 22-year-old woman is presented who developed fever, arthritis, and pustules and from whose cervix, rectum, and blood Neisseria gonorrhoeae could be grown. Based on the reports in the literature and our own experience indispensable and further desirable diagnostic measures to be adopted in such cases are discussed.

Adult↗
PubMed1983

Coincidence of primary malignant melanoma of skin and eye. Report of a case without B-K mole syndrome but with a further malignancy.

Although primary malignant melanomas of the skin or eye alone are not too rare, their coincidence is most uncommon. The case of a 41-year-old Caucasian male is reported who developed superficially spreading melanoma on the skin of his trunk 9 years after the enucleation of his right eye because of a fusiform melanoma of the choroidal membrane. Staging revealed a further malignancy: hemangiopericytoma inside and adjacent to the left psoas muscle. Both theoretical and practical conclusions to be drawn from the case are discussed.

Adult↗
PubMed1982

[Triple bacterial infection of the cervix uteri in benign gonococcal sepsis].

Benign gonococcal sepsis or disseminated gonococcal infection is a well defined clinical entity. Although the coincidence of several sexually transmitted diseases in the same patient has recently gained interest no case has been reported so far in which benign gonococcal sepsis was combined with further bacterial infections of the genitals. Therefore the case of a 25-year-old woman is reported who suffered from cervicitis, arthritis, and dermatitis due to neisseria gonorrhoeae infection and also harboured chlamydia trachomatis and ureaplasma urealyticum in her cervix. Facing this coincidence certain therapeutical and epidemiological conclusions must be drawn.

Adult↗
PubMed1982

Susceptibility of Neisseria gonorrhoeae to cefotaxime: in vitro studies and treatment results.

More and more beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae are nowadays isolated in most parts of the world including the European continent. Therefore, there is a need for reliable alternatives in the treatment of gonorrhoea. Cefotaxime--first representative of a new generation of beta-lactamase-resistant cephalosporins--was evaluated for this reason, first in vitro and then in vivo. All 191 strains tested proved susceptible, the highest MIC amounting to 0.03 microgram/ml, a drug concentration well exceeded in plasma for more than 4 h after i.m. application of 0.5 g cefotaxime. In contrast to other investigators we have therefore decided to test this relatively small dose clinically without the addition of probenecid. The clinical results were excellent: 146 of 151 patients (96.7%) were cured. In the female sub-group (34 patients) the cure rate amounted to 100%. Thus, the i.m. injection of 0.5 g cefotaxime as a single dose must be looked upon as a reliable regimen for the cure of uncomplicated gonorrhoea, both in males and females.

Cefotaxime↗
PubMed1982

Intraindividual variations of 8-methoxypsoralen plasma levels.

Intraindividual variations of 8-methoxypsoralen (8-MOP) plasma levels were investigated. On at least 3 consecutive days of treatment 8-MOP levels were determined 2 h following the administration of 0.56-0.82 mg/kg b.w. On day 1 a complete plasma level-time profile was obtained. Interindividually, 8-MOP plasma levels varied from 0-654 ng/ml. Intraindividual variation was considerably less being 1.2-5.3-fold. In one patient who showed a lower absorption rate of 8-MOP plasma levels varied from 0-126 ng/ml. There was a rather close correlation (r = 0.81) of the variation of 8-MOP plasma levels (determined as the ratio of highest to lowest plasma level) and mean plasma level, intraindividual variation decreasing exponentially with increasing 8-MOP plasma levels. Parameters determining variation of 8-MOP plasma levels are the intrinsic hepatic clearance, liver blood flow, and possibly the absorption of the drug from gastrointestinal tract. To keep intraindividual variation as low as possible ingestion of the drug together with a standardized meal is suggested. Drugs interfering with hepatic metabolism or liver blood flow should be avoided.

Adult↗
PubMed1982

Determination of 8-methoxypsoralen levels in plasma and skin suction blister fluid by a new sensitive fluorodensitometric method.

An improved fluorodensitometric assay for the determination of 8-methoxypsoralen (8-MOP) in plasma is described. Because of its low limit of detection (below 1 ng/spot) this method is suitable to determine the drug in skin suction blister fluid, too. The standard deviation of the procedure is 6.4% or less. Plasma and skin blister fluid levels of 8-MOP are determined 2 h following oral administration of 40-60 mg 8-MOP. They range from 0-239 ng/ml and 0-163 ng/ml, respectively. A rather close correlation (r = 0.91) between these two parameters could be observed. Thus, in cases with relatively high plasma levels sufficient skin levels can be predicted. If further investigations would prove, however, that a distinct concentration threshold required for therapeutic success exists--and recent experiments with fibroblast cultures imply that--skin blister fluid level determinations would seem highly desirable when plasma levels let us expect skin levels in the critical range. In general determination of 8-MOP skin blister fluid levels can be looked upon as a model for the evaluation of drug skin levels after systemic application in man.

Adult↗
PubMed1982

Does cantharides blister fluid provide access to the peripheral compartment?

The pharmacokinetics of bendroflumethiazide (BFT) was investigated following the oral administration of 10 mg to 3 healthy volunteers. Each subject participated twice in the study. BFT was determined in plasma and cantharides blister fluid from 1/2 to 30 h post administration. Blister fluid was obtained from blisters 10-22 h old. Plasma levels were fitted to a tri-exponential equation and the concentration of the drug in the peripheral compartment was calculated from the microscopic rate constants. In 5 of 6 cases investigated, cantharides blister fluid levels paralleled the concentration of the drug in the peripheral compartment. The mean blister fluid levels exceeded the calculated concentration in Compartment 2 1.46 fold. In one case, the blister fluid level paralleled the plasma level. This subject clearly differed from the others as more than 10 h were required for blister formation in her. The results suggest that following the administration of BFT, cantharides blister fluid behaves as part of the peripheral compartment. The possible value of studying blister fluid levels in pharmacokinetic investigations is discussed.

Adult↗
PubMed1982

[Coincidence of multiple cylindroma and trichoepitheliomas (Brooke-Spiegler-Syndrome)].

The coincidence of cyclindromas and trichoepitheliomas has been subject of a rather broad discussion for its principal pathogenetic aspects. Clinical cases, however, have only rarely been observed. Therefore, a case-report is given. Although the heredity of the Brooke-Spiegler syndrome seems well established by now, there is no anamnestic data in our case.

Adult↗
PubMed1981

Histological and cytological criteria in the diagnosis of malignant melanomas by cryostat sections.

Although cryostat sections in general allow a distinction to be made between malignant melanomas and other pigmented lesions in clinically doubtful cases, the differential diagnosis may be difficult. The histological and cytological criteria taken into account can be classified as major, minor, and insufficient. Knowing the diagnostic value of each makes a conventionally established diagnosis safer. Variance analysis does not contribute to the problem but it can nevertheless be shown that the evaluation of six major criteria makes a quick and reliable cryostat section diagnosis possible. If these results are confirmed in a prospective study it would be a decisive step on the way to a quicker and safer cryostat section diagnosis of malignant melanoma, even for the less experienced histopathologist.

Analysis of Variance↗
PubMed1981

[Multiple glomus tumors].

Two patients with disseminated glomus tumors (glomangiomas) are reported. Histologically, the angiomatous from typical of multiple glomus tumors was found. Th glomus tumors are related to the arterio-venous anastomoses (organ of Hoyer-Grosser). The most important histological variants are the epithelioid and the angiomatous type. Possibly, the former is related to the arterial segment, the latter to the venous segment of the normal arterio-venous anastomoses. The histological identification of glomus cells is diagnostic. The nature of these cells has been under discussion since Masson's time. Ultrastructurally, they have been clearly identified as modified smooth muscles cells. Electron-microscopy can be helpful in the differentiation of glomus tumors from hemangiopericytomas which may sometimes be difficult histologically.

Adult↗
PubMed1981

Gonococcal carriage in the throat--no common findings anyhow? Absence of Neisseria gonorrhoeae in the pharynges of 158 repeatedly swabbed young men.

Urethral carriage of gonococci is now accepted as a common phenomenon. During the last 10 years, moreover, gonococcal infections of the throat--both symptomatic and asymptomatic--have increasingly been demonstrated. As most investigations were undertaken in a highly selected population (VD patients), it seemed useful to screen a group of army recruits for the presence of Neisseria gonorrhoeae in their throats. In fact, while Neisseria meningitidis turned up very often, no such strains could be found. So gonococcal pharyngeal--other than urethral--carriage cannot be considered as a normal finding in an unselected population; as high as the corresponding rates in VD patients patients may be.

Adult↗
PubMed1981

[Amiodarone pigmentation. A rare, but typical drug side-effect].

Amiodarone is one of the most effective antiarrhythmic and anti-anginose drugs. A rare but typical side-effect with an incidence of 1:100 is sunburn, and of 1:1,000 a black-violet to slaty pigmentation of the sun-exposed skin areas. According to histochemical and ultrastructural findings the skin pigment deposits are considered to be lipofuscin.

Adult↗