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H C Jones

Publications and source records attributed to H C Jones.

96 records · Page 6Linked to original sources
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Inherited prenatal hydrocephalus in the H-Tx rat: a morphological study.

The H-Tx rat has inherited hydrocephalus which is present at birth. In order to investigate the onset and early stages of hydrocephalus, the heads of fetuses from 16 to 21 days gestation and at 1 day after birth, were serially sectioned using conventional wax histology. Lateral and third ventricle volumes were measured with a graphics tablet and microcomputer. Hydrocephalus was first detected at 18-20 days gestation by enlarged lateral ventricles and it was sometimes accompanied by a large third ventricle. Most hydrocephalics had a non-patent cerebral aqueduct between the third ventricle and the posterior collicular recess and the remainder (about 25%) had an aqueduct which was patent but with a smaller lumen than in non-hydrocephalic littermates. Some fetuses prior to 18 days gestation with normal lateral ventricles also had non-patent aqueducts. Abnormal aqueducts were lined by ependymal cells which were ventrally displaced by thickening of the overlying midbrain; also the subcommissural organ was foreshortened. Infusion with fluorescent markers confirmed that the flow pathway through the aqueduct was obstructed in many hydrocephalic rats. It is concluded that the hydrocephalus may be the result of abnormal brain development in the midline region of the dorsal mesencephalon, leading to aqueduct closure.

Animals↗
PubMedDate not supplied

Is tinnitus a psychological disorder?

There have been consistent reports in the psychosomatic literature indicating that a patient's perception of tinnitus as well as differential response to various treatment modalities may be affected by personality variables. The present study examined several personality correlates of subjective tinnitus in forty-five male patients referred to the Audiology Clinic of a large VA Medical Center with constant tinnitus of at least six months duration. Information was also collected on etiology, onset and chronicity, medications, prior treatment and related medical problems. Four standard psychological tests (MMPI, Cattel's 16 PF, Rotter's Locus of Control and Holmes and Rahe Life Stress Scale) were administered to all patients in the study, in addition to a comprehensive audiologic and otologic evaluation. Correlational analyses were used to examine the relationship between personality profiles and the demographic, medical and audiologic data. The expected psychosomatic characteristics of this patient population did not emerge as had been predicted from previous reports in the literature. Findings suggest that tinnitus may have an unwarranted reputation as a psychopathological disorder. Therefore, conventional psychotherapy may be of limited efficacy whereas standard audiologic treatment approaches may be more promising.

Adult↗