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Biomedical subjects

H C Friederich

Publications and source records attributed to H C Friederich.

At least 19 recordsLinked to original sources
PubMed1976

Biochemical and physiological parameters on the healthy skin surface of persons with candidal intertrigo and of persons with tinea cruris.

Biochemical and physiological tests were carried out on the skin surface of 20 patients with candidal intertrigo and 27 patients with tinea cruris. In all patients the test areas were free of efflorescences. The same tests were performed in 39 and 27 resectively healthy test persons of the same age and sex. The following striking findings came to light: 1. There was a significant decrease in the percentage amount of squalene in the skin surface lipids of the moniliasis group as compared with the control group. 2. There was a significant decrease in the reducing substances in the so called water solubles obtained with the phenol sulfuric acid method in the moniliasis group. The same results were obtained when only those moniliasis patients who were definitely not suffering from diabetes mellitus were taken into account. This is presumably a question of a reduction in the bound carbohydrates. 3. There were significantly more amino acids extractable from the skin surface of the tinea cruris patients than of the control persons. These results point to important predisposing factors for the susceptibility to candidal intertrigo and tinea cruris respectively.

Adolescent↗
PubMed1976

[Punching].

Explore the source record for details and available documents.

Biopsy, Needle↗
PubMed1976

Biochemical and physiological parameters on the healthy skin surface of patients with common warts.

Biochemical and physiological examinations were carried out on the healthy surface of the skin of 24 test persons who had had contracted common warts during the 2 years prior to examination and on a control group of 46 healthy persons of the same age and sex. The following significant results were obtained: (1) There was a significant reduction in the percentage amount of squalene in the lipids of the skin surface in the patients with common warts as compared with the healthy control persons. (2) The alkali neutralization time in the patients with common warts was significantly shortened as compared with the healthy control group. (3) The degree of moistening of the skin with water was significantly less in the patients with common warts than in the control persons. These results indicate important predisposing factors for common warts.

Adolescent↗
PubMed1975

Predisposing factors on the surface of the skin in persons with pityriasis versicolor.

This is a report on biochemical and physiological examinations carried out on 20 test persons who in the last 2 years had contacted and completely recovered from pityriasis versicolor and on 25 control persons of corresponding age and sex. The tests on the skin surface of the patients with pityriasis versicolor show, when compared with the corresponding control group, the following significant results: 1. Significantly more amino acids could be extracted from the skin of the pityriasis versicolor patients than from the skin of the control persons. 2. A significantly shorter alkali neutralisation time was to be found in the pityriasis versicolor patients than in the control persons. 3. The degree of water spreading on the skin was found to be significantly reduced in the pityriasis versicolor patients when compared with the control persons. It is probable that these results point to important predisposing factors for pityriasis versicolor.

Adult↗
PubMed1975

Predisposing factors of the skin surface in persons with impetigo contagiosa.

The following report describes the results of biochemical and physiological examinations in 32 persons, who had suffered from impetigo contagiosa in the last 2 years, as well as 21 control persons of the same age and sex. The examination of the skin surface of the patient group, when compared with the corresponding control group, showed the following significant results: 1. an increase in the percentage of free cholesterol in skin surface lipids possibly as a result of an increased cell turnover in the epidermis, 2. a decrease in reducing substances as revealed by the ferricyanide and the phenolsulfuric acid methods in the so called water solubles, 3. a decrease in the alkali resistance of the skin possibly as a result of a decreased barrier function of the stratum corneum. It is most likely that these results indicate predisposing factors, localized in the epidermis, for impetigo contagiosa.

Adolescent↗
PubMed1975

Biochemical and physiological particularities on the skin surface of diabetics.

Biochemical and physiological examinations were carried out on the skin surface of the following groups: on 16 newly diagnosed diabetics; on 26 diabetics receiving treatment; and on 2 control groups of 16 and 26 healthy persons respectively of corresponding age and sex. The tests on the surface of the skin of the newly diagnosed diabetics when compared with the corresponding control group show the following significant results: 1. An increase in the percentage of free cholesterol in the lipids of the skin's surface possibly as a result of an increased cell turnover in the epidermis. 2. An increase in the free fatty acid concentration to the disadvantage of the triglycerides in the lipids of the skin's surface as an expression of an improved bacterial lipolysis. 3. A decrease in the reducing substances as confirmed by the phenol-sulfuric acid method in the so called water solubles. 4. An increase in the amino acids as confirmed by the ninhydrin method in the so called water solubles. All the above mentioned changes were more pronounced in the newly diagnosed diabetics than in those already receiving treatment; it can be seen that these changes can partly be normalised under diabetic therapy.

Aged↗
PubMed1975

Biochemical and physiological parameters on the skin surface of healthy test persons: a contribution towards the interpretation of the results obtained by a screening program.

Biochemical and physiological examinations were carried out on the skin surface of a total of 115 healthy persons ranging from the age of 7-79 years. In these investigations the following striking findings were made: 1. There is a significant correlation between the results obtained by the ferricyanide, the phenol sulfuric acid and the ninhydrin methods in the so called water solubles. 2. The relationship between the fraction of wax and cholesterol esters and the squalene fraction in the skin surface lipids influences the release of free fatty acids by bacterial lipases. 3. With regards to most parameters tested there are great differences between the 8-12 year age group and the older age groups. 4. There are significant differences in the 8-12 year age group between the male and female test persons. 5. With regards to the parameters tested there are also significant differences between the various test areas.

Adolescent↗