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H C Dillon

Publications and source records attributed to H C Dillon.

68 records · Page 4Linked to original sources
PubMed1970

Complement in overt and asymptomatic nephritis after skin infection.

In an ongoing study of streptococcal skin infection and acute glomerulonephritis (AGN) begun in 1964, C'3 determinations were done in 784 patients. There were 126 patients with acute poststreptococcal nephritis, 172 of their siblings, and 486 patients with uncomplicated impetigo from families without an index case of nephritis.90% of the patients with nephritis were infected with one of the four prevalent streptococcal serotypes associated with nephritis in this population; only 12% of patients with uncomplicated impetigo were infected with similar serotypes.93% of the patients with overt nephritis had diminished complement levels. Low complement was more often observed (8%) in AGN siblings than was transient hypertension and/or hematuria (5%). Considering the relationship of low C'3 alone and low C'3 preceded hematuria in four others. Two (0.4%) of the patients with uncomplicated impetigo had low complement values, both of whom were infected with nephritogenic strains. Transient hematuria and/or hypertension was less frequently observed (2.7%) among patients with uncomplicated impetigo. Serial determinations in patients with low complement revealed a return to normal in a linear fashion within 2-12 wk. The validity of the hypothesis that the asymptomatic patients with low complement levels, with or without hematuria, likely had subclinical nephritis is strengthened by the accompanying epidemiologic data. The finding of low complement before the onset of, or in the absence of, hematuria or other evidence of nephritis supports the concept that an immunologic mechanism may precipitate the renal injury of acute streptococcal nephritis.

Adolescent↗
PubMedDate not supplied

Immunochemical characterization of the polysaccharide antigens of group B streptococci.

Mouse monoclonal antibodies were used in the immunochemical characterization of the polysaccharide antigens of group B streptococci (GBS). Monoclonal antibodies specific for the sialylated form of the GBS type III polysaccharide were highly protective in a mouse model of GBS type III infection, whether of IgM, IgG2a, or IgA isotypes, but monoclonal antibodies specific for the nonsialylated form of the type III antigen were not protective, regardless of isotype. Monoclonal antibodies reacting with the type II polysaccharide antigen could be divided into two general antigen binding groups on the basis of the ability of beta-methylgalactopyranoside to inhibit their binding to purified type II antigen. Various proportions of antibodies with the two specificities were observed in rabbit and human sera. Although it was previously reported that rabbit antisera could not distinguish between the sialylated and nonsialylated forms of the type Ib polysaccharide, mouse monoclonal antibodies were found to exhibit exclusive specificity for one or the other form of the antigen. Only monoclonal antibodies specific for the sialylated Ib polysaccharide were protective in a mouse model.

Animals↗
PubMedDate not supplied

Post-streptococcal glomerulonephritis following pyoderma.

Studies of the epidemiology of acute glomerulonephritis (AGN) following pyoderma reported over the past 15 years have been reviewed. Investigations in Alabama, at Red Lake in Minnesota, and in Trinidad proved of special interest because they contribute new information concerning the natural history of streptococcal skin infections and the role of such infections in AGN. Interesting contrasts between streptococcal infections of the skin and those of the throat are now apparent. Compared with pharyngeal infections, skin infections are more common in young preschool children, are caused by different serotypes, and differ in the nature of the streptococcal antibody response. A number of new M-serotypes of group A streptococci, including several of importance in AGN, were found in studies of pyoderma. In contrast to M-types 1 and 12 (those of major importance in AGN followng pharyngitis), M-types 2, 49, 55, 57, and 60 are now recognized to be of major importance in AGN following pyoderma. Although streptococcal skin infections are quire important in AGN, they do not result in acute rheumatic fever.

Glomerulonephritis↗
PubMedDate not supplied

Clinical and epidemiologic studies of pneumococcal infection in children.

Streptococcus pneumoniae was isolated from 1310 children in a 5-year period from 1979 through 1984. There were 44 cases of meningitis, 172 bacteremic infections, 787 cases of otitis media and 307 respiratory and miscellaneous isolates. The majority of infections could be accounted for by a small number of serotypes, with types 3, 6, 14, 19 and 23 predominating. Most infections (70%) occurred in infants younger than 2 years of age. However, nearly one-fourth of those suffering systemic illness had some underlying condition which may have contributed to their risk for infection, even beyond 2 years of age. Ten of the 12 deaths occurred in patients with altered host defenses. Characteristics of pneumococcal disease and the distribution of serotypes are discussed in relation to the work of other investigators over the past 50 years.

Age Factors↗