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Biomedical subjects

H C Carlson

Publications and source records attributed to H C Carlson.

At least 55 records · Page 3Linked to original sources
PubMed1975

Retrograde pancreatography in autopsy specimens.

Sixty-two pancreases were dissected at autopsy. In 55 of them, the pancreatic ducts were filled with 50 per cent Hypaqje and roentgenograms were made prior to dissection. Clinical information (available in every case) was correlated with the gross and microscopic findings and findings on the pancreatograms. The anatomically and functionally predominant duct was considered the "main pancreatic duct" regardless of its embryologic development. The common bile and main pancreatic duct opened independently into the duodenum in 8 of the 62 cases (13 per cent). The accessory pancreatic duct had a patent orifice into the duodenum in 12 of 57 cases (21 per cent). The ampulla of Vater was well developed in only 4 of the 62 cases (6 per cent), but an ampullary dilatation was present twice as often at the end of the acessory pancreatic duct, in both those that ended blindly and those that opened into the duodenum. The orifices for the accessory duct were often tiny pinhole openings. There were 2 primary carcinomas of the pancreas, one in the head and one in the tail. The pancreatic duct was almost completely obstructed in each case. Both tumors were undifferentiated adenocarcinomas, and extravasation occurred into each one of them. Extravasation also occurred into a necrotic lymphoma involving the tail of the pancreas, and into two areas of abscess formation in another case. Diffuse, dense, fluffy opacification of pancreatic parenchyma, due to alteration in cell membrane permeability, was demonstrated in acute pancreatitis, infarction, autolysis, and overfilling of the ducts by vigorous injection. Three pancreases showed microscopic changes of chronic pancreatitis. The pancreatogram on one was normal, but the microscopic changes were minimal, and pancreatitis was not suspected clinically. The other 2 cases were symptomatic, and their pancreatograms showed strictures and irregularities of the main pancreatic duct as well as saccular ectasia was present in three additional pancreases, two of which showed squamous metaplasia of ductal epithelium without other microscopic stigmata of chronic pancreatitis and no clinical features to suggest pancreatitis. The possibilities exist that ectasia of secondary ducts and squamous metaplasia of ductal epithelium are manifestations of low-grade injury and that "subclinical pancreatitis" may be common in the general population.

Adult↗
PubMed1975

Alleviating mortality associated with a vitamin E-selenium deficiency by dietary ascorbic acid.

Adding ascorbic acid to a practical ration deficient in vitamin E and selenium for the growing duck substantially reduced associated mortality. The continued appearance of various myopathies but absence of vascular faults supported implication of a reduced de novo ascorbate synthesis as part of the syndrome. Presumably, alleviation of this induced secondary inadequacy with its more lethal pathology was the primary reason for the lower death rate.

Animal Feed↗
PubMed1975

Inclusion body disease in a great horned owl.

The carcass of a great horned owl (Bubo virginianus), which had been found moribund in southern Ontario, was presented for necropsy. Throughout the liver and spleen were numerous white foci 1-2 mm in diameter; also noted were white plaques in the mucosae of the pharyngeal papillae and intestine. Results of light and electron microscopic studies and experimental transmission to two captive great horned owls suggested that this was a herpvirus disease similar and possibly indentical to the owl disease reported by other workers in Wiconsin and Australia.

Animals↗
PubMed1975

Pathology of spontaneous hemorrhagic enteritis of turkeys.

Thirteen turkeys naturally affected with hemorrhagic enteritis were studied pathologically. The main gross lesions were splenomegaly and hemorrhagic contents in the gut. The main histological lesions were intranuclear inclusion bodies in largemononuclear cells in many visceral organs and in reticular cells around the sheathed arteries of the spleens and varying degrees of lymphocytic hyperplasia in most tissues. The inclusions were frequently present in areas of the lymphocytic hyperplasia. The large mononuclear cells with the inclusions frequently showed a degenerative change.

Animals↗
PubMed1975

Electron microscopic findings of cells with inclusion bodies in experimental hemorrhagic enteritis of turkeys.

The spleen, liver, bone marrow and intestines of two turkeys in which hemorrhagic enteritis of turkeys was experimentally reproduced were examined electron-microscopically. Intranuclear inclusion bodies as described in a previous report were found in all the tissues examined. These occupied most of the area in affected nuclei and were composed of viral particles with morphological characteristics of an adenovirus. The cells with the inclusions were divided into two types of cells, immature and reticular cells. There was some variety in the stage of differentiation of the former cells. As the viral particles developed the cells degenerated and disintegrated. A few particles had been released into the cytoplasm of the degenerated cells but no particles were present in intercellular spaces.

Adenoviridae↗
PubMed1975

Intraluminal duodenal diverticulum. Report of two cases and review of the literature.

Diverticula rarely occur within the lumen of the duodenum. They arise near the papilla of Vater and extend distally. The diverticulum is lined on both sides with duodenal mucosa, and its eccentric opening is usually proximal in the sac. The diverticulum results from incomplete recanalization of the intestinal lumen after the proliferative epithelial stage in the 7-week embryo and represents either a remnant of one of two channels formed during recanalization or a distal ballooning of a congenital duodenal diaphragm. Although the patient with a diverticulum may be asymptomatic, most patients present with abdominal pain and obstructive symptoms; pancreatitis and gastrointestinal bleeding may be associated with the diverticulum. Barium study shows a characteristic radiolucent halo that represents the wall of the diverticulum. Surgery should be approached with caution because injury to the papilla is a hazard, and in children, coexisting congenital anomalies may be present.

Adult↗
PubMed1973

Marble spleen disease of pheasants in Ontario.

Two outbreaks of marble spleen disease were observed in pen-raised pheasants in Ontario on the same farm in the summer of 1971 and in 1972. In both instances, a mortality of 3% per day lasted for approximately 14 days. Fifteen birds were necropsied and tissues removed and examined histologically and by electron microscopy. In addition splenic material was injected into adult pheasants. The gross lesions, characterized by enlarged greyish-white mottled spleens and acute congestion and oedema in the lungs, were identical to those described by previous authors. Histological examination of livers, lungs, spleens and proventriculi revealed some reticular-type cells which contained either an eosinophilic or a basophilic intranuclear inclusion. Electron microscopy of the affected spleens revealed cells with massive intranuclear accumulations of virus particles. Although transmission trials failed, the evident histological and electron microscopy lesions confirm the suggestion by other authors that this is a viral disease affecting the reticulo-endothelial system.

Animals↗