Search PubMed⌕ Search

Biomedical subjects

H C Burry

Publications and source records attributed to H C Burry.

At least 19 recordsLinked to original sources
PubMed1979

A comparison of sulindac with ibuprofen in the management of rheumatoid arthritis.

Sulindac 200mg b.i.d. was compared with ibuprofen 400mg t.d.s. in a double-blind controlled trial in patients with rheumatoid arthritis. Both drugs produced a measurable and significant improvement from baseline levels, in both objective and subjective parameters. All parameters favoured sulindac but the differences were not statistically significant. Side effects were infrequent with both drugs and in all but three cases did not necessitate withdrawal from the trials. Sulindac appears to be an effective anti-inflammatory analgesic drug for the management of rheumatoid arthritis with a low incidence of side effects.

Adult↗
PubMed1979

Benign rheumatoid nodules.

Nine cases in which subcutaneous rheumatoid nodules were observed in the absence of any evidence of rheumatoid arthritis are recorded. In four of these cases, the nodules appeared during adolescence or adult life, a very rare phenomenon. Synovitis occurred in only one patient, after an interval of 15 years, but it did not persist and other features of rheumatoid arthritis were not present. The siting of the nodules in the sub-cutaneous tissue, the absence of features suggestive of rheumatic fever, necrobiosis lipiodica or fungal infection, and lack of any history of trauma, together with the histological appearance, supported a diagnosis of rheumatoid nodules. In all cases, serological tests for rheumatoid factor were negative but in the only case investigated with immunofluorescent staining, IgG and IgM were demonstrated in the biopsy material. It is important to recognise the fact that these benign nodules do not necessarily indicate that the patient has rheumatoid arthritis, or will develop rheumatoid arthritis in the future. The possible relationship of such nodules to granuloma annulare is discussed.

Adolescent↗
PubMed1978

Pathogenesis of some traumatic and degenerative disorders of soft tissue.

1. Trauma to soft tissues is associated with tissue rupture and formation of a haematoma. 2. Such lesions cannot be expected to resolve without complications in the absence of appropriate treatment. 3. Myositis ossificans should be anticipated in lesions of muscles adjacent to their attachments. 4. Chronic tendonitis and enthesopathies not associated with inflammatory connective tissue disease are primarily degenerative in nature and are probably the result of comparative ischaemia. Mesenchymoid transformation is a feature of both.

Contusions↗
PubMed1978

Lateral subluxation of the atlanto-axial joint in rheumatoid arthritis.

Involvement of the cervical spine by rheumatoid disease is common, but lateral subluxation at the atlanto-axial level has not been recorded previously. The condition is due to asymmetrical erosion of the lateral atlanto-axial facet joint, and may be complicated by collapse of the lateral mass of the axis. The condition should be suspected in patients with rheumatoid arthritis (RA) who present with occipital, auricular, and/or facial pain.

Adult↗
PubMed1977

A trial of feprazone in ankylosing spondylitis.

Feprazone, a non-steroidal anti-inflammatory drug, was compared with indomethacin in a double-blind cross-over trial in 24 patients with ankylosing spondylitis, over eight weeks. Both regimes caused significant reduction in pain. There were fewer side-effects and more patient preferences with feprazone but these differences did not reach statistical significance.

Adult↗
PubMed1977

Low back injury in sport.

Low back injuries are shown to present a serious hazard to sportsmen and women, and may lead to long-term disability in relation to their sport. Training methods, particularly weight training, led to many of the injuries and it is recommended that personnel involved in training become more aware of these dangers. Spondylolysis was found in 18% of cases and it is suggested that the full investigation of low back pain in a sportsman is incomplete until this lesion has been excluded.

Adolescent↗
PubMed1977

Effect of intra-articular corticosteroid injections on primate cartilage.

An attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. The knee joints of 10 Macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. Minor degenerative changes of many femoral condyles were shown by India ink staining and by a system of histochemical grading. Changes in the joints injected with corticosteroid were not significantly different from those seen in control joints. The findings were in striking contrast to the severe degeneration reported by others in rabbit joints injected with corticosteroid. The experiment did not support the contention that intra-articular corticosteroids invariably have a deleterious effect on primate cartilage.

Animals↗
PubMed1976

Apparent reduction of endogenous creatinine clearance by salicylate treatment.

A prospective study of nine patients with rheumatoid arthritis and 11 healthy volunteers who started salicylate treatment showed that in 18 of the 20 subjects creatinine clearance values fell the average being 25%. Serum creatinine concentration was increased by an average of 38%, although blood urea levels were unchanged. Since 51Cr-edetic acid clearance tests performed at the same time in 12 of the subjects were not affected, the fall in creatinine clearance was probably not due to impaired glomerular function, and salicylate ingestion may therefore invalidate the creatinine clearance test as an index of glomerular filtration rate. It is clearly important to inquire into the patient's analgesic comsumption when using the creatinine clearance test to assess glomerular function.

Clinical Trials as Topic↗
PubMed1976

Renal disease in rheumatoid arthritis.

N-Acetyl-beta-D-glucosaminidase (NAG) is a sensitive indicator of renal damage. When the urinary NAG levels of 60 patients with rheumatoid arthritis (RA) were measured a highly significant difference was detected between the mean urinary NAG excretion of the patients with RA (341 +/- 294-92 nmol h-1 mg creatinine-1) and that of 60 matched controls (67-53 +/- 16-93 nmol h-1 mg creatinine-1). In 10 patients studied no correlation could be shown between the urinary NAG levels and levels in either serum or synovial fluid. A significant positive correlation was noted between urinary NAG excretion and disease activity as estimated by the Lansbury activity index, the Ritchie articular index, and the haemaglobin level. An abnormally raised urinary NAG excretion was detected in eight out of 20 previously untreated patients with RA, which suggested that the rheumatoid process may affect renal function.

Acetylglucosaminidase↗
PubMed1976

Salicylates and renal function in rheumatoid arthritis.

The effect of salicylate treatment on the kidney, particularly medullary function, was investigated. In a retrospective analysis patients with rheumatoid arthritis (RA) treated with high doses of salicylates were shown to have inferior urinary concentrating power and increased excretion of N-acetyl-beta-D-glucosaminidase (NAG) when compared with patients who had not received salicylate treatment. A prospective study of renal funcition in healthy people and patients with RA starting salicylate in therapeutic doses showed that while epithelial cell excretion was only transiently raised in both groups the excretion of NAG was increased in all cases at three days and this increase was sustained at 10 days, all values being much higher in the patients than in the healthy subjects. Thus salicylate treatment does cause renal tubular damage but this damage results in only minimal impairment of function and does not constitute a reason for withholding salicylate treatment.

Acetylglucosaminidase↗
PubMed1976

Gastrointestinal blood loss on phenylbutazone and feprazone.

Feprazone, a new anti-inflammatory drug, is a useful antirheumatic preparation which causes little gastrointestinal upset. This short cross-over study shows no significant gastrointestinal blood loss with either feprazone or phenylbutazone by the red-cell chromium-51 labelling method.

Arthritis↗
PubMed1976

Sulindac in osteoarthrosis of the hip.

Sulindac (400 mg/day) has been compared with ibuprofen (1200 mg/day) in 40 patients with osteoarthrosis of the hip, over an eight-week period, in a double-blind controlled clinical trial. The two drugs were comparable in terms of patient preference, effects on hip movements, and toxicity. Sulindac showed superior analgesic properties to ibuprofen, resulting in a significantly greater reduction in pain on weight-bearing and with passive movements (P less than 0.01).

Adult↗
PubMed1976

Ketoprofen -- a new anti-rheumatic agent.

Ketoprofen (100 mg/day) and indomethacin (100 mg/day) were compared in a double-blind cross-over trial of four weeks duration in 46 patients with rheumatoid arthritis. The drugs were equally effective in all parameters measured, apart from the paracetamol (rescue drug) tablet count which favoured indomethacin. In a similarly designed study the same dosages of the two drugs were compared in 44 patients with osteoarthrosis of the hip. No significant differences occured between the two groups. A further double-blind cross-over study of 4 weeks duration compared 200 mg ketoprofen/day and 300 mg phenylbutazone/day in 47 patients with osteoarthrosis of the hip. No significant differences occured between the two drugs. In all three studies, side-effects with ketoprofen were infrequent and mild. Biological monitoring throughout revealed no abnormality. These studies have shown ketoprofen to be an effective anti-inflammatory for the treatment of rheumatoid arthritis and osteoarthrosis of the hip with an efficacy comparable to those of indomethacin and phenylbutazone.

Analgesics↗
PubMed1975

A double-blind cross-over trail of Prenazone and aspirin in the management of rheumatoid arthritis.

A double-blind cross-over trial of Prenazone 600 mg and Aspirin 4 g daily was carried out on 20 patients suffering with rheumatoid arthritis. The analgesic and anti-inflammmatory activity was indistinguishable from that of aspirin under the conditions of the trail. Twelve patients expressed a general preference for Prenazone and six for aspirin. Prenazone appeared to be well tolerated and free from serious side-effects. These results suggest that it will be a useful drug in the management of rheumatoid arthritis.

Aged↗