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Biomedical subjects

H Buxton

Publications and source records attributed to H Buxton.

5 recordsLinked to original sources

Balance between four types of synaptic input for the integrate-and-fire model.

We consider the integrate-and-fire model with AMPA, NMDA, GABA(A)and GABA(B)synaptic inputs, with model parameters based upon experimental data. An analytical approach is presented to determine when a post-synaptic balance between excitation and inhibition can be achieved. Secondly, we compare the model behaviour subject to these four types of input, with its behaviour subject to conventional point process inputs. We conclude that point processes are not a good approximation, even away from exact presynaptic balance. Thirdly, numerical simulations are presented which demonstrate that we can treat NMDA and GABA(B)as DC currents. Finally, we conclude that a balanced input is plausible neither pre-synaptically nor post-synaptically for the model and parameters we employed.

Animals↗

A computational model of the analysis of some first-order and second-order motion patterns by simple and complex cells.

Although spatio-temporal gradient schemes are widely used in the computation of image motion, algorithms are ill conditioned for particular classes of input. This paper addresses this problem. Motion is computed as the space-time direction in which the difference in image illuminance from the local mean is conserved. This method can reliably detect motion in first-order and some second-order motion stimuli. Components of the model can be identified with directionally asymmetric and directionally selective simple cells. A stage in which we compute spatial and temporal derivatives of the difference between image illuminance and the local mean illuminance using a truncated Taylor series gives rise to a phase-invariant output reminiscent of the response of complex cells.

Algorithms↗

Auditory lateralization: an effect of rhythm.

Recall of monaurally presented semantically anomalous sentences, which had either neutral or rhythmic timing, was tested at the right ear, at the left ear, and on transfer from one ear to the other. The component words, being computer stored digitized waveforms, had identical acoustic structure in the two conditions. In the rhythmic condition there was not only an overall advantage in the second half of the experiment but also an asymmetric transfer effect such that this advantage did not appear when the left ear was tested after the right. It is proposed that functional lateralization be viewed as an adaptive, dynamic, organizational factor.

Adult↗