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Biomedical subjects

H Brynger

Publications and source records attributed to H Brynger.

At least 109 records · Page 6Linked to original sources
PubMed1983

Autologous renal transplantation and pyelocystostomy after unsuccessful pyeloplasty.

A total of 4 patients with persistent outflow obstruction after pyeloplasty for hydronephrosis was reoperated with renal autotransplantation and pyelocystostomy. All 4 patients had undergone an unsuccessful Anderson-Hynes pyeloplasty and 2 also had had a second operation. All patients had relief of pain, normalization of urine outflow and improved renal function during an observation of 27 to 37 months. Occasional asymptomatic bacteriuria occurred in 2 patients. Thus, renal autotransplantation and pyelocystostomy may be considered a useful and safe method to eliminate persistent outflow obstruction after unsuccessful pyeloplasty.

Adult↗
PubMed1983

Transfused cadaver kidney donors and graft survival.

A retrospective study of blood transfusion to the cadaveric kidney donor and graft survival in 129 primary transplantations between 1973 and 1981 in a single center is presented. Only transfusions given while the donor had the fatal disease were considered. Among 109 earlier transfused recipients graft survival calculated according to actuarial methods was significantly higher in 55 patients who received kidneys from transfused donors than in 54 patients who received kidneys from donors who had not been transfused (P less than 0.05). We conclude that transfusion to the cadaveric kidney donor positively affected graft survival in recipients who had been transfused.

Adolescent↗
PubMed1983

Autologous renal transplantation with direct pyelocystostomy in the treatment of recurrent renal calculi.

Six male patients with severe recurrent urinary calculus disease underwent renal autotransplantation with direct pyelocystostomy to allow spontaneous passage of stones. The only serious complication was an early renal vascular thrombosis with graft loss in one patient who had been operated on three times before with ipsilateral partial resections for nephrolithiasis. The other five patients did well (observation time 4-34 months). Their renal function has remained unchanged. Autotransplantation with direct pyelocystostomy should be considered in patients with multiple recurrent stones of the upper urinary tract, especially when some degree of obstruction has developed or when other predisposing anomalies prevail.

Adult↗
PubMed1983

Pancreatic duct occlusion with Ethibloc. An experimental study in juvenile pigs.

In the transplantation of vascularized pancreatic grafts severe problems are related to the exocclusion is an improved alternative to duct ligation in producing atrophy of the exocrine pancreas while leaving the endocrine pancreas intact. Fractional growth rate in duct-ligated and duct-occluded animals was reduced to 1/3 - 1/4 of that of sham operated controls. Fasting blood glucose, fasting insulin, sum of blood glucose and glucose elimination rate during an intravenous glucose tolerance test remained normal in the duct-ligated and Ethibloc-occluded animals. There was a diminished insulin response to a maximal glucose load. In spite of this, the glucose tolerance remained virtually normal. The volume of the pancreas was reduced to 1/3 of its normal size after both experimental procedures. Histologically, the islets appeared to remain normal, while the exocrine portion of the gland was replaced by fibrous tissue. No traces of the active compound, Ethibloc, remained after 4 weeks. This study shows that pancreatic duct occlusion with Ethibloc results in impairment of endocrine function. Consequently, Ethibloc duct occlusion does not seem to be a superior alternative to other methods of producing exocrine atrophy in organs intended for transplantation.

Animals↗
PubMed1983

Renal transplantation across a blood group barrier--'A2' kidneys to 'O' recipients.

The outcome of 11 renal transplants with kidneys from blood group A2 donors to blood group O recipients is reported. Eight grafts had a satisfactory function, three early losses were noted: one acute rejection after four weeks, two technical failures. The longest survival is four years, the patient died from septicaemia with a functioning graft. Obviously, the blood group A2-O incompatibility is not an obstacle to successful organ transplantation.

ABO Blood-Group System↗
PubMed1983

Prognostic factors at the time of renal retransplantation.

One hundred and eighty-two patients with a second cadaver (CD) transplant performed during 1969-80 showed similar patient and graft survival to that of 535 recipients of first CD grafts. Loss of the first graft after 12 months resulted in a significantly higher second graft survival (GS II) than loss in early acute rejection within three months, 71 per cent vs 34 per cent at one year (p less than 0.01). A high frequency of presensitised patients was observed (53%) which negatively influenced the GS II, at one year 55 per cent vs 40 per cent for patients without and with antibodies (p less than 0.01). A good HLA-A, B match and absence of antibodies positively influenced GS II. Blood transfusions prior to the first transplantation did not influence survival of the second graft.

Adult↗
PubMed1983

Pancreas transplantation in streptozotocin-diabetic juvenile pigs. Evaluation of function among duct-ligated, duct-occluded, and nonligated allografts.

This study examined pancreatic allograft function in transplanted diabetic juvenile pigs. The grafts were transplanted with ligated, occluded (Ethibloc) or open ducts. No immunosuppression was used. Irreversible and permanent diabetes was induced by streptozotocin. Graft function was assessed by measuring glucose tolerance and insulin production during an i.v. glucose tolerance test. The fractional growth rate of the transplanted host was used to evaluate the long-term consequence of transplantation. Normal glucose tolerance was achieved in 50%, and a slight impairment in 10% of the animals. In 35%, no detectable graft function was observed. Duct-ligated and Ethibloc-occluded grafts had a significantly lower function rate within the first week compared with grafts with open ducts. The fractional growth rate was significantly decreased in animals receiving grafts with occluded ducts. This was probably not due to different insulin production. No graft failures were observed within the first week in open-duct graft transplantations. Graft failures were associated with elevated serum alpha-amylase and were probably due to vascular impairment. Normal glucose tolerance in transplanted pigs was associated with elevated levels of normal insulin and C-peptide in peripheral blood, concomitant with low levels of proinsulin. Our results show that a pancreatic graft should be transplanted with open ducts. Obstructed ducts lead to an increased frequency of graft failure, while the transplanted hosts with such functioning grafts show retarded growth due to unidentified factors.

Animals↗
PubMed1982

Clinical and diagnostic considerations in Fabry's disease.

Three patients with Fabry's disease with a similar clinical picture, including recurrent burning sensations in the extremities, hypohidrosis and slowly progressive renal insufficiency, have been investigated metabolically at different stages of renal impairment. One patient died after three unsuccessful renal transplantations in a 4-year period of intermittent haemodialysis with disabling pains. One successfully transplanted patient is still alive and well, 12 years after the start of therapy. Thermolabile alpha-galactosidase has been demonstrated in his urine. The third patient has slowly progressive renal impairment. No therapeutic enzyme replacement available today is ideal. Early diagnosis is therefore necessary to increase the possibilities of prenatal diagnosis and genetic counseling.

Adolescent↗
PubMed1982

Dialysis treatment and psoriasis in Europe.

One hundred and fifty out of 944 European dialysis centers reported experience with patients suffering from psoriasis. Ninety-three centers returned special questionnaires on 97 patients with end stage renal failure (ESRF patients) and on 49 patients dialyzed for psoriasis but who had normal renal function (NRF patients). Improvement of skin disease was reported in 17 out of 27 NRF patients according to both "objective criteria" and the patients' personal opinions. However, most of these patients had been on dialysis for less than one year (9.9 +/- 11.1 months) which is too short to allow for the spontaneous recurrence of psoriasis. In contrast, 60% of ESRF patients had been on dialysis for 45 +/- 3.1 months. Skin disease definitely improved in 20% of these patients after commencement of dialysis. This proportion is greater than the expected spontaneous long-term remission of psoriasis.

Adult↗