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Biomedical subjects

H Bruns

Publications and source records attributed to H Bruns.

At least 19 recordsLinked to original sources
PubMed1980

Electron microscopic studies of herpes simplex virus type 1 infection of macrophages, T- and B-lymphocytes of mice.

The course of infection with herpes simplex virus type 1 (HSV-1) in peritoneal macrophages, phytohemagglutinin (PHA-)stimulated (T-)lymphocytes and lipopolysaccharide (LPS-)stimulated (B-)lymphocytes of NMRI-mice was studied by means of electron microscopy. Non-stimulated as well as thioglycolate-stimulated macrophages were investigated; lymphocytes were derived both from HSV-1-sensitized and non-sensitized animals. The morphological characteristics of the abortive infection in macrophages and T-lymphocytes and of the productive infection in B-lymphocytes are described. No differences were observed between stimulated and non-stimulated cells or cells of sensitized and non-sensitized animals.

Adsorption↗
PubMed1979

[Computer and chemical synthesis].

Numerous computer programs have gained entry into drug research; some of them are already used as a matter of routine, whereas others are still being tested. The special advantages of the use of computer programs are shown for the two fields "computer-assisted synthesis planning" and "quantitative structure-activity relationships". Several aspects of cooperation between man and computer are briefly discussed.

Computers↗
PubMed1979

[Contribution to the etiology of coxarthrosis. Radiographic and clinical evaluation of 976 arthrotic hip joints (author's transl)].

Radiograms and case histories of 654 randomized patients with 976 arthrotic hip joints have been reviewed in an attempt to make an etiological diagnosis. 98.3% of the patients and 98.8% of arthrotic hips, respectively, could be determined as to their underlying praearthrotic deformities according to Hackenbroch sen. The respective mean value gained from 6556 patients published in the world literature is 74.2% with marked individual variations. Most frequent praearthrotic condition was found to be congenital hip dislocation, followed by epiphyseolysis capitis femoris juvenilis, trauma, coxitis, M. Perthes, coxa vara, protrusio acetabuli, idiopathic femoral head necrosis, ankylosing spondylitis and several more rare basic conditions.--The most important reasons for differing results are discussed: Specific composition of clinic cases, completeness of documentation, experience of the reviewer and considerable space for personal interpretation. Relevant epidemiological data are also mentioned; they are in agreement with clinical experience and published data.--Finally it is stated that present diagnostic methods are not able to detect all praearthrotic conditions.

Adolescent↗
PubMed1978

[An implantable femur distractor for operative leg lengthening (author's transl)].

A new femur distractor has been developed, lengthening the leg. This instrument is electronically controllable and can be implanted totally. It is possible to regulate transcutaneously by radio control the operation "forward motion", "stop" and "backward motion". After testing this instrument in sheep, the lengthening of human femur by this system can be introduced.

Bone Lengthening↗
PubMed1978

[Epicondylitis of the humerus (author's transl)].

Principles of Treatment and Results after Hohmann's Operation: The method of clinical examination and rational conservative measures including physiotherapy are discussed in the light of the literature and the results of a cooperative study. To summarize briefly it may be said that conservative therapy should first of all be completely exhausted. Local injections of a corticosteroid should not exceed 3 and at most 6. If conservative therapy is unsuccessful after 4 months, operation is indicated and the extended Hohmann operation performed.

Adrenal Cortex Hormones↗
PubMed1978

[Anaesthesia and intracellular distribution of cerebral hexokinase (author's transl)].

The purpose of the present investigation was to demonstrate how the intracellular distribution of hexokinase was influenced by anaesthetics. The experiments were carried out using mice in vivo and the isolated perfused rat brain. Thiopentone (100 mg/kg i.p.) produced an increase of soluble hexokinase activity in brains of mice which were removed from the skull in 45 s to 120 s. A solubilization of hexokinase activity was demonstrable in the surgical stage of anaesthesia, when the animals awoke redistribution to control values was measurable. A dose dependent influence of thiopentone on hexokinase distribution was demonstrated in the isolated perfused rat brain. When the thiopentone concentration in the perfusion medium was increased (0.05-0.8 mM) the soluble hexokinase activity was elevated while the EEG activity was reduced up to isoelectricity.

Anesthetics↗
PubMed1976

[Further experiences with total hip arthroplasty. Clinical and roentgenographic results after 3--6 years following implantation (author's transl)].

Report on 236 re-examined total hip arthroplasties performed between 3 and 6 years before (69 Huggler-Weber I and 167 McKee-Farrar joints). 76% of the patients were satisfied with their results on the base of acceptable pain control, increased joint mobility and improved functional capacity. Negative estimations usually could be verified by clinical and roentgenographic findings, the main reason for failures being aseptic loosening of one or both of the implant components in a present rate of 17.8%. Additional failures were due to infectious loosening (2.7%) and pararticular ossification (1.3%). Aseptic loosening of Weber-Huggler implants (33%) occured three times as often as with McKee-Farrar joints and usually was confined to the acetabulum. The influence of different factors such as patient's age and previous surgery, preoperative roentgenographic findings, etiology of coxarthrosis and operative technique has been evaluated. It is concluded that the present way of implant cementation with acrylics offers no sufficient long term anchorage and total hip arthroplasty therefore presently should be confined to the elderly. However, the results may be improved by strict indication and proper surgical technique.

Age Factors↗