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Biomedical subjects

H Brincker

Publications and source records attributed to H Brincker.

102 records · Page 6Linked to original sources
PubMedDate not supplied

Itraconazole treatment of pulmonary aspergillosis in leukaemia patients during a nosocomial epidemic associated with indoor building renovation.

During indoor building renovation a nosocomial epidemic of pulmonary aspergillosis occurred in a haematological ward, involving 10 patients with acute leukaemia undergoing intensive chemotherapy. Antifungal treatment included the combination of amphotericin B and 5-fluorocytosine during periods of granulocytopenia, followed by itraconazole after bone-marrow recovery. In five patients, lung aspergillomas disappeared completely, while significant improvement was observed in a further two patients. Itraconazole appeared to contribute significantly to the result, but the drug did not work during granulocytopenic episodes. Air analyses showed increased counts of fungal spores in ward locations with heavy traffic of patients and staff, suggesting the need to identify and avoid risk areas when placing patients undergoing intensive chemotherapy.

Adult↗
PubMedDate not supplied

Two pregnancy-associated late relapses in acute lymphoblastic leukemia.

Late relapses of acute lymphoblastic leukemia occurred in two women in associated with pregnancy, 7 and 17 years, respectively, after the initial diagnosis of leukemia. In both cases and in a similar pregnancy-associated case in the literature relapse was accompanied by the appearance of vacuolization in the leukemic lymphoblasts. In order to explain how late relapses can occur at all and how they may be triggered by endocrine events such as pregnancy, it seems necessary to assume that some leukemic cells are not autonomous and that they may preserve the faculty of normal homeostatic regulation.

Adolescent↗