[Blood histamine and early retrospective diagnosis of anaphylactic shock].
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Biomedical subjects
Publications and source records attributed to H Bricard.
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In the last few years, the tremendous growth of clinical transplantations has greatly increased the need for grafts. Combined heart, liver and kidney harvesting in a same donor could provide an answer. The results are presented of multiple organ retrieval (MOR) carried out in an University hospital located in an area with 1,350,000 inhabitants. In addition to the usual problems of donor maintenance and legal aspects, it was necessary to carry out a specific work-up for each organ to be harvested. The job of the local coordinator was extremely important in the search for potential recipients and the organization of the procedure (time-table, air transport) in order to give optimal conditions. The priority given to retrieving the heart and in situ cooling of the liver and kidneys guaranteed the good quality of the harvested organs. Over a period of three years, 28 MOR have been carried out. Of the 94 organs harvested, 88 were transplanted in France or another European country (49 kidneys, 23 hearts, 16 livers); 75 are still functioning (47 kidneys, 19 hearts, 9 livers). As a result of this experience, and taking into account the need for organs, all brain dead patients should be considered as potential multiple organ donors, and not just as kidney donors. The intervention of several teams, often quite distant from the site of retrieval, requires careful planning. The surgical procedure, even when performed by a trained team, is often complex, perfect synchronization of the surgical steps of the operation being the most important point.(ABSTRACT TRUNCATED AT 250 WORDS)
The authors have compared intraocular pressure in during induction and intubation mode. All measures were made with an aplanation tonometer (Schiotz), before induction, after induction, and immediately after intubation. Both NNLA and propofol induced an important decrease of the IOP, more with propofol (45.6%) than with NLA (28.1%). It increased again during intubation, but less with propofol (-26.8%) than with NLA (+9%).
Since 1980, details of all patients operated upon in a digestive surgery unit have been entered on record-cards with the view of obtaining information on the activity of the unit and improving post-operative care. Over a 3-year period, 2005 patients underwent surgery, 25% of them for cancerous lesions. Biliary tract operations (385 patients), fundoplication by the abdominal route for gastro-oesophageal reflux (58 patients) and curative resection of the colon for carcinoma (100 patients) were set apart for evaluation. For each of the above pathologies, morbidity, mortality and duration of stay in hospital in cases with uneventful or complicated post-operative course were analyzed. Annual audits of this kind result in accurate evaluation and periodical reappraisal of the therapeutic habits of the medico-surgical team.
A high-performance liquid chromatographic method is described which determines noxytiolin and 1-methyl-2-thiourea concentrations in serum. Valid determination requires immediate ultracentrifugation of blood samples, rapid serum freezing, and injection into the chromatograph within 6 h. A number of pharmacokinetic parameters were calculated from serum concentration data in rabbits and humans. An unknown metabolite was detected in both species but its structure was not identified.
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This work proposed: 1) to record all the anaesthetic information in the SYSRES system, 2) to carry out a global numerical evaluation of the surgical risks in the form of a coefficient (CORI) defining a probability of complications thanks to a table established from several hundred case-files. This method has several purposes: the carrying-out of very quick summaries of case-files, and of statistical studies, several of which could be used as a basis in scientific work and, most of all, allow an increase in the safety of the patients.
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The patient who was operated on for the recurrence of a colic cancer had an unknown pituitary adenoma. The adenoma was destructing partly the anterior basis of the skull and was protruding in the nasal fossae. The naso-gastric tube entered without any difficulty the right cerebral hemisphere creating lethal cerebral lesions. Some reflexions determined by this very rare condition are discussed.
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