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Biomedical subjects

H Brettel

Publications and source records attributed to H Brettel.

13 recordsLinked to original sources

Computerized simulation of color appearance for dichromats.

We propose an algorithm that transforms a digitized color image so as to simulate for normal observers the appearance of the image for people who have dichromatic forms of color blindness. The dichromat's color confusions are deduced from colorimetry, and the residual hues in the transformed image are derived from the reports of unilateral dichromats described in the literature. We represent color stimuli as vectors in a three-dimensional LMS space, and the simulation algorithm is expressed in terms of transformations of this space. The algorithm replaces each stimulus by its projection onto a reduced stimulus surface. This surface is defined by a neutral axis and by the LMS locations of those monochromatic stimuli that are perceived as the same hue by normal trichromats and a given type of dichromat. These monochromatic stimuli were a yellow of 575 nm and a blue of 475 nm for the protan and deutan simulations, and a red of 660 nm and a blue-green of 485 nm for the tritan simulation. The operation of the algorithm is demonstrated with a mosaic of square color patches. A protanope and a deuteranope accepted the match between the original and the appropriate image, confirming that the reduction is colorimetrically accurate. Although we can never be certain of another's sensations, the simulation provides a means of quantifying and illustrating the residual color information available to dichromats in any digitized image.

Algorithms↗

Effect of the pulse length of ultrasound on cell membrane damage in vitro.

Suspended cells of a human lymphoblastic cell line were exposed to pulsed ultrasound of 775 kHz. The pulse lengths were varied between 16 and 1000 microseconds. The mark/space ratio was always kept at 1:1. Two ultrasound intensity levels were used: 3.6 and 6.4 W/cm2 spatial peak and temporal peak. After an exposure time of 5 min, cell membrane damage was measured cytometrically by a dye exclusion test. No membrane damage was observable at 16 microseconds, whereas, at pulse lengths of 1000 microseconds, about one-third of the cells were damaged.

Cell Line↗

Cell membrane damage by ultrasound at different cell concentrations.

Cell membrane damage by ultrasound was studied in human nucleated cells in vitro at various concentrations. Suspensions of human blood cells, cells of a human leukemic cell line (Reh) and mixtures of nucleated cells with erythrocytes were exposed to continuous ultrasound of 782 kHz at a SPTA intensity of 15 W/cm2. The surviving nucleated cells without membrane damage were counted on the basis of exclusion of ethidium bromide using a flow cytometer. At high cell concentrations as present in whole blood, we observed no cell death, whereas below 5 X 10(7) cells/ml most of the granulocytes, stimulated lymphocytes and Reh cells were damaged. The concentration threshold below which cells were damaged seemed not to depend on the size of the cells, rather on the concentration of particles in the suspension.

Cell Aggregation↗

Discrimination thresholds in the two-dimensional spatial frequency domain.

In two experiments we have determined the discriminability between two sinusoidal gratings as a function of orientation and spatial frequency differences. Twelve orientation (15 degrees steps) and four spatial frequencies (2, 4, 8, 12 c/deg) were considered and corresponding discrimination thresholds were determined. Results indicated that: (a) spatial frequency discrimination thresholds did not significantly vary over all frequency and orientation positions, and averaged at +/- 1/8 octave limits. (b) Orientation thresholds only slightly increased with spatial frequency (from +/- 5 degrees at 2 c/deg to +/- 6 degrees at 12 c/deg). (c) A large and consistent anisotropy occurred with orientation thresholds showing most sensitivity in the horizontal and vertical directions, with largest thresholds at the oblique angles. No oblique effect was observed with spatial frequency thresholds. These results confirm past observations, providing an extensive set of threshold measurements in the two-dimensional spatial domain.

Discrimination, Psychological↗

Modelling perceptual distortion: amplitude and phase transmission in the human visual system.

In this paper we consider the complementary properties of image amplitude and phase components and their role in normal and amblyopic vision. Specific two-dimensional filtered images are included to demonstrate the possible perceptual distortions due to both amplitude and phase disturbances. Finally, the relationships between amplitude and phase filters are discussed with reference to the types of receptive field distributions expected to underly the normal and abnormal cases.

Amblyopia↗

Insensitivity of peripheral vision to spatial phase.

Tolhurst (1973) had suggested that movement-sensitive mechanisms were the human analogues of transient (Y) neurones in the cat (Enroth-Cugell and Robson 1966) and monkey (Gouras 1968) visual system. We challenged this view in a previous study (Rentschler et al. 1981): in strabismic amblyopia the detection of apparent movement of counterphased gratings is impaired considerably more than pattern detection, whereas no such anomaly is found when the sensitivity to temporal transients is tested. This would imply that with a grating target the detection of lateral movement and of transients is not mediated by the same class of mechanisms. Moreover, we have shown that normal peripheral vision suffers qualitatively from the same kind of movement insensitivity as the amblyopic eye. In this study, we have used a wider range of stimulus parameters to seek more definite evidence.

Humans↗

Amblyopic abnormality involves neural mechanisms concerned with movement processing.

In strabismic amblyopia the detection of apparent movement for counterphase gratings is considerably more impaired than the detection of pattern. No such anomaly is found for the detection of changes from a blank field when gradual or abrupt onsets or offsets of the temporal grating presentation are used. Similarly, normal peripheral vision is relatively poor in detecting alternation of spatial phase. It is concluded that the observed movement abnormality does not reflect a loss in sensitivity of transient mechanisms but rather a visual insensitivity to spatial phase. This would explain why perceptual distortions and low optotype acuity occur in amblyopes with normal contrast sensitivity.

Amblyopia↗

Spatial tuning properties in human amblyopia cannot explain the loss of optotype acuity.

Strabismic amblyopes may exhibit in their squinting eye an almost normal contrast sensitivity to gratings although their optotype acuity is strongly impaired. This discrepancy cannot be accounted for by reduced selectivity of spatial-frequency channels or line-sensitivity functions. Alternative explanations for the loss of letter visual acuity as abnormal interactions between psycho-physical detector-mechanisms or defects in spatial phase sensitivity are discussed.

Adult↗

[Transmission sonographic diagnosis of infant hips].

By means of transmission sonography with incoherent ultrasound it is possible to obtain areal cross-section images of infants' hips which are free of interference and demonstrate axes accurately. It is possible to assess the condition of tendons, ligaments, capsular structures, and the bones, and their relative positions. The authors report on experience gathered since 1982 with the instrument developed at the Gesellschaft für Strahlen- und Umweltforschung (Society for Radiation and Environmental Research) in Munich. In addition to a brief description of the unit and an explanation of the examination technique, they discuss criteria of assessment and demonstrate on the basis of sample results that transmission sonographic findings can be assessed reliably in patients up to the age of 9 months. The possible significance of transmission sonography in the diagnosis and observation of congenital dislocation of the hip is discussed.

Hip Dislocation, Congenital↗