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Biomedical subjects

H Blattmann

Publications and source records attributed to H Blattmann.

63 records · Page 4Linked to original sources
PubMed1979

Low-dose effects of X-rays and negative pions on the pronuclear zygote stage of mouse embryos.

Mouse embryos in the pronuclear-zygote stage (day 0 of gestation) were irradiated with 13.5 rad of 140kV X-rays or negative pions. On day 13 the fetuses were examined for developmental anomalies such as intrauterine death, growth retardation and malformations. Significant decreases in the percentage of normal implantations were obtained with peak pions (high LET) and X-rays, whereas the effect of plateau pions was less obvious. Irradiation with peak pions was more effective than with X-rays by a factor of about 1.7.

Abnormalities, Radiation-Induced↗
PubMed1979

Effect of negative pi mesons on vascular permeability of brain in neonatal rats.

Neonatal rats and their radiation-induced cerebral petechial hemorrhages were used as an experimental system for evaluating the effects of negative pions on healthy tissue and especially on the microvasculature. Dose response curves for peak and plateau pions (dose range 150--250 rad and 100--400 rad, respectively) were obtained and compared with those of 200 kV X-rays of corresponding dose rates. The RBE of the peak pions was 1.1, that of the plateau pions 0.6 resulting in a peak/plateau ratio of 1.8. Implications were made as to the importance of this favorable peak/plateau relationship since the response of the capillary endothelium to pion-irradiation might be one of the limiting factors in radiotherapy.

Animals↗
PubMed1977

Effects of low-dose irradiation with x-rays and pi-mesons on embryos of two different mouse strains.

The effects of two different kinds of radiation (X-rays and negative pions) on embryonic development of mice was examined. The application of a known radiosensitizer (lucanthone) combined with 13.5 rd whole-body irradiation on day 8 of gestation showed enhanced teratogenic action compared to treatment with each of the agents alone. The extent of intensification varied both with mouse strain and treatment, indicating possible differences in repair capacity and LET-dependency of sensitization effects. Strain differences were found in the incidence and type of chemical and radiation-induced malformations, which may be explained by different developmental stages at the time of treatment.

Animals↗
PubMedDate not supplied

Proton irradiation of feline nasal planum squamous cell carcinomas using an accelerated protocol.

Fifteen cats were treated for squamous cell carcinoma of the nasal planum using proton beam radiation. The protocol used was accelerated with eight equal fractions given on four consecutive days, with a minimum of six hours between fractions. Total dose of radiation delivered was escalated with nine cats receiving 40.4 CGE (60Co Gy equivalent), and three cats each receiving 42.4 and 44.8 CGE. Complete response to the protocol was 60% (9/15), partial response was 33% (5 of 15), and no response was seen in 6.6% (1 of 15). Tumor control rate at one year was 64% and no cat had tumor recurrence after one year. Median survival was 946 days (+/- 516 days). Side effects were minimal with no severe reactions noted in the early or late period. This protocol offers an effective treatment for squamous cell carcinoma of the feline nasal planum with minimal side effects and may be adaptable to conventional radiation sources particularly when the field size is very small.

Animals↗