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Biomedical subjects

H Binder

Publications and source records attributed to H Binder.

At least 91 records · Page 5Linked to original sources
PubMed1988

Is aphasia an additional prognostic factor in ischemic stroke with regard to the severity of hemiparesis in the subacute stage?

The outcome of 122 patients with ischemic stroke in the left carotid territory (ascertained by CT) was investigated using mailed questionnaires after a mean follow-up time of 60.7 months (SD 20.5 months). Patients who had had cerebrovascular accidents others than TIA prior to the stroke were not included in the study. The relationship between the degree of aphasia in the postacute stage and the long-term outcome was evaluated with regard to the severity of motor deficits. With respect to survival, recurrent stroke, single activities of daily living such as dressing, personal hygiene, walking, feeding, bowel management and overall self-care status, the outcome of patients was not dependent on the severity of aphasia. Aphasia did also not serve as a prognostic factor in returning to work after left hemispheric cerebral infarction. Our results indicate that in presence of motor deficits the severity of aphasia in the subacute stage does not additionally influence the long-term outcome after left hemispheric cerebral infarction.

Activities of Daily Living↗
PubMed1988

[Prognosis of social reintegration following stroke].

From the socio-economic point of view, early prediction of outcome after stroke is of essential value. The longterm prognosis of 310 patients suffering from ischemic stroke, was therefore investigated by means of questionnaires. The mean follow-up period was 62.5 (S.D. 21.9) months. The results of patients who had suffered cerebrovascular accidents other than ischemic stroke or only transient ischemic attacks were not included. It had been the aim of the study to determine the predictive value of some clinical variables and symptoms in the subacute stage as regards the familial and social functioning handicaps to be expected later on. Between the number of strokes as well as the severity of some clinical signs (motor deficits, sensory deficits, speech disorders, organic mental syndrome) on the one hand, and the restrictions experienced in familial functioning on the other hand, a clear cut correlation was found. As regards social functioning, two additional predictors of unfavourable outcome could be identified: age, and lesion within the left hemisphere. The findings indicate that some clinical variables and symptoms in the subacute stage are of great predictive value concerning the ensuing handicap in familial and social functioning. These variables may help to develop individual strategies as regards the further social management and support (e.g. discharge arrangements, care services, rehabilitation programs).

Adolescent↗
PubMed1987

[Reversible opening of the blood-brain barrier in the chemotherapy of malignant gliomas].

The concept of a blood brain or blood tumour barrier blocking the passage of lipid insoluble cytoreductive drugs from blood into brain-tumor, leads to a protocol of intraarterial injection of high dose methotrexate (MTX) during reversible, osmotic blood brain barrier disruption (BBBD). Malignant Gliomas of grades III and IV in 9 patients and one primary CNS-lymphoma in one patient have been treated in 2 to 5 sessions per patient with BBBD plus polychemotherapy (MTX, cyclophosphamide, procarbazine). Median progression free intervals (PFI) which are still in continuation are 12.2 months. Median PFI which had been terminated by tumour recurrence are 7.75 months.

Antineoplastic Agents↗
PubMed1987

Congenital muscular torticollis: results of conservative management with long-term follow-up in 85 cases.

A retrospective review of 277 patients with congenital muscular torticollis seen between 1970 and 1982 was conducted. In 85 cases this was supplemented by questionnaires and recent photographs, permitting a two- to 13-year follow-up. The first visit for 81.6% of patients was before six months of age. All were enrolled in a specific physical therapy program at the time of the first visit, unless they presented with severe torticollis after 12 months of age. Torticollis was mild to moderately severe in 90.6% of cases. Sternomastoid fibrotic nodules were present in 38.6%, more frequently in the more severe cases. Hip dysplasia increased in direct relation to severity and occurred in 10.5% of cases. At 12 months the torticollis had been conservatively resolved in nearly 70% of patients regardless of severity and presence or absence of focal fibrosis. Tenotomies were indicated in only ten children, eight of whom had first been seen after 12 months of age. Long-term sequelae were mild and consisted of craniofacial asymmetry, intermittent head tilt, and mild scoliosis. Developmental asymmetry or high tone due to limited mobility in the cervical spine were noted in 25.3% of infants initially and tended to subside with appropriate therapy. However, 11.8% of patients with long-term follow-up showed persistent functional asymmetry of the involved body side despite mild or moderate severity, early diagnosis, and complete resolution of the torticollis. Long-term observations indicate that congenital torticollis rarely requires surgical treatment.

Female↗
PubMed1986

Activation of V1-receptors by vasopressin stimulates inositol phospholipid hydrolysis and arachidonate metabolism in human platelets.

The activation of platelet V1-receptors by vasopressin (0.01-1 microM) induces the rapid formation of inositol phosphates, 1,2-diacylglycerol and phosphatidic acid, indicating inositol phospholipid hydrolysis by phospholipase C. Vasopressin immediately induces the formation of inositol bisphosphate and inositol trisphosphate. Accumulation of inositol 1-monophosphate and inositol 4-monophosphate occurs later after a time lag of 15 s. Low concentrations (10-100 nM) of vasopressin only activate phospholipase C, whereas high concentrations (1 microM) induce activation of phospholipase C and subsequently the production of arachidonate metabolites. Cyclo-oxygenase metabolites are associated with further activation of phospholipase C, release reaction and irreversible platelet aggregation. Vasopressin requires for its action extracellular Mg2+, but not Ca2+. The described platelet changes are not induced by 1-desamino-[8-D-arginine]vasopressin, a V2-receptor agonist, and are blocked by a specific V1-receptor antagonist. The results indicate that platelets possess a V1-receptor that is coupled to polyphosphoinositide hydrolysis by phospholipase C, leading to the formation of 1,2-diacylglycerol and inositol trisphosphate. Those compounds may act as second messengers for platelet responses induced by vasopressin, whereas endoperoxides and thromboxane A2 stimulated by vasopressin may serve as amplifiers for platelet activation.

Arachidonate Lipoxygenases↗
PubMed1986

Blood brain barrier modification and chemotherapy. Interventional neuroradiology in the treatment of malignant gliomas.

Postoperative interventional neuroradiology was performed in patients with malignant gliomas to increase target efficacy of chemotherapy. In 8 glioma patients the blood brain or blood tumor barrier was reversibly opened by intraarterial injection of hyperosmolar fluid (Mannitol 25%). One additional patient had primary lymphoma of the central nervous system. During barrier modification chemotherapeutic agents were applied intraarterially and intravenously. A total of 22 blood brain barrier modification procedures have been carried out until now, ranging from one to five per patient. A presently continuing tumor regression or tumor progression free intervals have been noted in 5 patients. Therapeutic effects are being evaluated from repeated computed tomography and single photon emission computed tomography examinations.

Adult↗
PubMed1985

Thrombin induces the rapid formation of inositol bisphosphate and inositol trisphosphate in human platelets.

Human platelets prelabeled with [3H]inositol were exposed to thrombin. The aqueous soluble inositol phosphates were separated by anion exchange column chromatography, paper chromatography or high-performance liquid chromatography, and identified by cochromatography with authentic standard substances. Thrombin immediately induces the rapid formation of inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate. Accumulation of inositol-1-monophosphate and inositol-2-monophosphate occurs later after a time lag of 10 sec. The results indicate that the phospholipase C induced polyphosphoinositide hydrolysis rather than the phosphatidylinositol hydrolysis is the triggering event for platelet activation, and support the concept of inositol 1,4,5-trisphosphate as putative second messenger.

Blood Platelets↗
PubMed1985

Separation of inositol phosphates and glycerophosphoinositol phosphates by high-performance liquid chromatography.

We developed a HPLC method which separates the following nine inositol-containing compounds of biological interest: inositol, inositol 1-monophosphate, inositol 2- or 4-monophosphate, inositol 1,2-cyclic phosphate, inositol 1,4-bisphosphate, inositol 1,4,5-trisphosphate, glycerophosphoinositol, glycerophosphoinositol 4-monophosphate, and glycerophosphoinositol 4,5-bisphosphate. The method shows good resolution and sufficient recovery (70-80%) for each compound. By applying this method to human platelets prelabeled with [3H]inositol and stimulated with thrombin, we found an early increase of inositol 1,4-bisphosphate and inositol 1,4,5-trisphosphate. Accumulation of glycerophosphoinositol, inositol 1-monophosphate, and an inositol monophosphate which cochromatographs with inositol 2- and inositol 4-monophosphate occurs later. The method is simple, and--after removal of salts from the incubation buffer--can be directly applied to the measurement of aqueous soluble [3H]inositol-labeled compounds in biological samples.

Chromatography, High Pressure Liquid↗
PubMed1985

[Tetrachloroethylene: effect of low concentrations of 1,1,2,2-tetrachloroethylene (perchloroethylene) on organisms in the mouse. I. Laboratory chemical research].

Tetrachloroethylene in a concentration of 0.05 resp. 0.1 mg/kg bw/d was offered in drinking water to a group of NMRI-mice. Besides a decrease in bodyweight an increase in the relative weight of the spleen resp. of the kidneys could be determined. The liver and the brain remained uneffected. In the offered concentration, tetrachloroethylene influenced the lipoprotein metabolism in the liver in the sense of a chronic-alcohol-toxic liver change, whereas the liver cell was not destroyed in toto. The unchanged rate of the synthesis of liver cells could be established sufficiently through the normal serum-glutamate-pyruvate-transaminase, an unchanged serum electrophoresis as a measure for the efficiency of the protein synthesis of the liver cells, furthermore a swelling of the liver and/or an enlargement of the liver could not be diagnosed. The erythropoietic system was found to be most susceptible to tetrachloroethylene. We could detect a defect like in the case of hemolytic anemia, this manifested itself in a very high increase of the lactatdehydrogenase, in an increase of the LD-isoenzyme-1, as well as in the occurrence of reactive initial stages of erythrocytes in the bone marrow and in the moderate degree of a hyperchrome anemia in the peripheral blood-count.

Administration, Oral↗
PubMed1985

[Tetrachloroethylene: effect of low concentrations of 1,1,2,2-tetrachloroethylene (perchloroethylene) on the mouse. II. Study of tetrachloroethylene in various organs and demonstration of histological changes in the examined organs].

Perchlorethylene in subacute amounts in form of contaminated drinking-water was given to a group of NMRI-mice (group A = 0,05 mg PER/kg BW/d and group B = 0,1 mg PER/kg BW/d) over a period of seven weeks. The histologic changes of various organs and the perchlorethylene-residues in the examined organs have been determined. We only could establish the light-microscopic perceivable histologic changes in the spleen. Thus the pulpa cords were rich in erythrocytes and the area of the red pulpa contained plenty of blood-formation-centers with megakaryocytes. In the spleens of group B a siderin-storage in the red pulpa in macrophages could be established. These results are indicative for an increased hemolysis. In all of the examined organs, the heaviest accumulation of perchlorethylene we could be established in the spleen, whereby the concentration in the spleen amounted to several times as much as the residue-examinations of the other organs. In the liver for instance an insignificant amount of PER was stored. The erythrocytes and the fragments of them, that have been changed by the storage of PER are being decomposed in the spleen, and perchlorethylene reaches the spleen via the erythrocytes.

Administration, Oral↗
PubMed1984

[Real-time sonography of the skull in the newborn].

The results of 293 examinations of the skull by sonography in 170 newborn are presented. In 73 patients the results could be compared with the findings on CT or at post mortem. In 48%, abnormal sonograms of the skull were obtained, due to congenital abnormalities, hydrocephalus or intracerebral bleeds. High accuracy and wide application make real time sonography the diagnostic procedure of first choice for the examination of the brain of the newborn. An attempt has been made to determine the optimum time for the examination and suitable intervals for follow-up.

Agenesis of Corpus Callosum↗
PubMed1984

Mitoxantrone and cyclophosphamide in advanced breast cancer: a pilot study.

A trial of combination chemotherapy using mitoxantrone-cyclophosphamide was started in 1983. Sixteen patients with widely metastatic cancer of the breast, including one man, received mitoxantrone, 10 mg/m2 intravenously (IV) over 30 minutes on day 1, followed by cyclophosphamide, 200 mg/m2 by mouth (PO) daily in divided doses on days 3 to 6. It is too early to evaluate four patients at present. The remaining 12 received three or more courses of treatment, and three of these patients achieved a complete response. Another four patients went into partial remission, amounting to an overall response rate of 58%. The other evaluable patients showed stable disease with improved symptoms. Hematologic toxicity was mainly granulocytopenia, but thrombocytopenia occurred in two patients. Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy. Mitoxantrone appeared to have no cardiac toxicity. It was concluded that mitoxantrone-cyclophosphamide is an effective chemotherapeutic combination with minimal toxicity and should be further studied in larger controlled trials.

Adult↗