Search PubMed⌕ Search

Biomedical subjects

H Bickel

Publications and source records attributed to H Bickel.

At least 91 records · Page 5Linked to original sources
PubMed1975

[Glucose, fructose and xylitol as energy carriers in postoperative parenteral nutrition (comparative studies) (author's transl)].

The effects of fructose, glucose and xylitol, as well as their mixture in a proportion of 2:1:1 were measured and compared in the postoperative phase in a uniform group of patients receiving these substances during a 6-hour infusion. Carbohydrate balance, carbohydrate blood levels, changes in acid-base equilibrium and rises of lactate and uric acid were used as criteria for assessing the various substrates and their mixtures. Using these criteria, a carbohydrate mixture consisting of fructose, glucose and xylitol (2: 1: 1) proved to be better than the various substrates by themselves in equivalent amounts.

Acid-Base Equilibrium↗
PubMed1975

Determination of phenylalanine hydroxylase activity in patients with phenylketonuria and hyperphenylalaninemia.

The phenylalanine hydroxylase assay was modified by using biopterin, lysolecithin, and dithioerythritol. Liver tissue was obtained by percutaneous needle biopsies in patients with phenylketonuria (PKU) and hyperphenylalaninemia. The use of the naturally occurring cofactor biopterin is essential to measure low enzyme activities. Thirteen of 14 assay specimens in which no activity was detectable correlated with the clinical picture of classic PKU. Twelve assay specimens showed a residual activity up to 6% of normal. This group comprises patients with classic PKU and with so-called hyperphenylalaninemia. Four specimens ranged between 8.7 and 34.5% of the normal values. Patients in this group have developed normally so far without dietary treatment. It seems that patients with residual activity tolerate more phenylalanine in the diet than patients with no detectable activity. One infant with biochemical symptoms of classic PKU was found to have a normal phenylalanine hydroxylase activity.

Adolescent↗