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Biomedical subjects

H Bergman

Publications and source records attributed to H Bergman.

At least 127 records · Page 7Linked to original sources
PubMed1988

The Swedish Alcohol Use Inventory (AVI), a self-report inventory for differentiated diagnosis in alcoholism.

AVI is a self-report inventory intended for standardized and differentiated assessment and diagnosis in alcoholism; it includes 75 items adapted from Horn and Wanberg's Alcohol Use Inventory (AUI) and an assessment of the alcohol intake during a typical week of heavy drinking. The drinking profile is presented in five second-order factor scales: 'alcohol abuse', 'psychological benefits', 'interpersonal complications', 'social drinking' and 'daily drinking' and in 17 first-order factor scales. The reliability and specificity of the scales are satisfactory. Preliminary norms based on a sample of more than 600 alcoholic patients are available. Using the original American scoring and norms the results indicate important similarities in the alcoholism pattern between Sweden and the U.S.A.

Adult↗
PubMed1987

Tumorigenic responses to lindane in mice: potentiation by a dominant mutation.

Obese mottled yellow Avy/a, lean pseudoagouti Avy/a and lean black a/a (YS X VY) F-1 hybrid female mice were fed diet containing 160 p.p.m. lindane (gamma-hexachlorocyclohexane) for 6, 12, 18 or 24 months. Clara cell hyperplasia was present in a majority of the mice after six months of lindane ingestion; however, more yellow mice (77%) than pseudoagouti (50%) or black (56%) mice had developed this lesion. Continued ingestion of lindane increased the incidence of Clara cell hyperplasia and resulted in similar prevalences in the three phenotypes. Lung tumors associated with lindane ingestion for 24 months were found only in yellow (19%) and pseudoagouti (14%) mice but not in the black mice. Prevalences of hepatocellular adenomas and carcinomas were very low (less than 10%) in untreated pseudoagouti and black mice. Lindane ingestion for 24 months resulted in an hepatocellular adenoma prevalence of 12% in pseudoagouti mice and 3% in black mice; comparable hepatocellular carcinoma prevalences were 5% and 1%. Among yellow mice fed lindane diet for 24 months, adenoma prevalence was 35% (9% among untreated controls) but carcinoma prevalence was only 17% (13% among controls). The tumorigenic responses evoked by lindane feeding in the lean pseudoagouti Avy/a mice but not in the black a/a mice indicate, for the first time, that the Avy gene itself, in the absence of obesity, sensitizes cells to transformation. The greater prevalence of hepatocellular adenomas in obese yellow Avy/a than in lean pseudoagouti Avy/a mice implicates obesity-associated factors in tumor promotion. Similarly, the increased prevalence of hepatocellular carcinomas in untreated obese yellow Avy/a mice, as compared to lean pseudoagouti mice, implicates obesity-associated factor as favoring histiotypic progression of liver tumors. Thus, the Avy gene not only sensitizes cells to respond to tumorigenic stimuli but also, by the induction of obesity, enhances promotion and progression of transformed cells.

Adenoma↗
PubMed1987

The relation between drinking habits and neuroticism and weak ego among male and female alcoholic patients.

The relationship between drinking habits and personality functioning was studied in a consecutive series of 300 alcoholic inpatients during treatment and 2 1/2 years later. The alcoholic sample showed more signs of neuroticism and lack of ego strength than the general population. Among the alcoholics there was a relationship between advanced drinking habits and more pathological personality functioning. However at the follow-up improved drinking habits were connected only with improved self-esteem, particularly among female patients.

Adult↗
PubMed1987

Social network density and rehospitalization among young adult patients.

The authors interviewed 30 patients under age 40 who had been hospitalized repeatedly to determine the relationship between social network density, or the extent to which network members know one another, and rehospitalization. They found that moderate levels of network density were associated with fewer days in the hospital. Time spent in the hospital was not related to network size, and patient diagnosis was not a good predictor of hospitalization. The authors hypothesize that a moderately dense network is optimal for psychologically vulnerable individuals because it can be maintained under stress.

Adult↗
PubMed1987

Heavy alcohol drinking and related symptoms in a population study of urban men.

An age-stratified random sample of 228 men was selected from the urban districts of Solna and Sundbyberg in Stockholm. Two hundred of these men (90%) underwent a health survey comprising a general medical examination, taking of a medical and social history, blood and urine tests, roentgenography of the heart and lungs, ECG, electroneurography and computed tomography of the brain. The purpose of the present study was to determine alcohol consumption levels and their correlation with symptoms of heavy drinking and with age. The subjects were collected according to a rectangular age distribution, with age ranges of 20-29, 30-39, 40-49, 50-59 and 60-65 years. Quartiles were used in order to obtain homogeneous strata and to group the sample concerning alcohol consumption. Two measures of alcohol consumption were used--the amount of alcohol consumed in the previous week in g of absolute alcohol per day, and the typical peak consumption in the last six months. Three symptoms related to heavy drinking were studied: (1) inability to cut down or stop drinking, referred to here as subjective, relative loss of control over drinking; (2) morning shakes and malaise relieved by drinking, termed morning drinks; (3) amnesia induced by alcohol, referred to as blackouts. Ten per cent of the men had all three alcohol symptoms and 52% had no alcohol symptoms at all. Twenty-nine per cent had lost control over the amount they drank. Blackouts were noted for 33% and morning drinks for 25%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

Comparison of the tumorigenic response of SENCAR and C57BL/6 mice to benzo(a)pyrene and the inter-experimental variability over a three-year period.

SENCAR and C57BL/6 mice were compared for their ability to produce tumors after benzo(a)pyrene [B(a)P] initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion. SENCAR mice initiated with 101 micrograms/mouse B(a)P and promoted with TPA (2 micrograms/mouse, twice weekly) produced large numbers of papillomas, whereas C57BL/6 mice produced none after 26 weeks of promotion. Continued treatment of the B(a)P-initiated C57BL/6 mice with TPA up to 52 weeks did not induce any papillomas nor did higher doses of B(a)P. Application of increased doses of TPA (10 micrograms/mouse, twice weekly) to B(a)P-initiated C57BL/6 mice (404 micrograms/mouse) for 50 weeks produced few papillomas. Substantial papilloma formation in C57BL/6 mice was observed after weekly treatment with B(a)P (101 micrograms/mouse), with maximal production occurring at weeks 39 to 41 of treatment. In contrast, SENCAR mice treated according to the same protocol produced an equivalent response with maximal papilloma formation occurring 12 to 13 weeks earlier. Therefore, C57BL/6 mice exposed to B(a)P are capable of producing papillomas under certain experimental conditions. The inter-experimental variability of B(a)P-induced (50.5 micrograms/mouse) papilloma formation after 30 weeks of TPA promotion (2 micrograms/mouse, twice weekly) was examined in SENCAR mice over a 37-month period. Low statistical variation was observed in papilloma multiplicity, papilloma incidence, or papilloma latency. Male and female SENCAR mice produced equal values in the three parameters: 4.4 +/- 1.6 papillomas/mouse, 87% +/- 10% of the mice bearing papillomas, and 9.6 +/- 1.3 weeks (time at which 10% of the mice bore papillomas). The numbers of papillomas per mouse did not follow a Poisson distribution.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

Cognitive deficits and morphological cerebral changes in a random sample of social drinkers.

A random sample of 200 men and 200 women taken from the general population as well as subsamples of 31 male and 17 female excessive social drinkers were investigated with neuropsychological tests and computed tomography of the brain. Relatively high alcohol intake per drinking occasion did not give evidence of cognitive deficits or morphological cerebral changes. However, in males, mild cognitive deficits and morphological cerebral changes as a result of high recent alcohol intake, particularly during the 24-hr period prior to the investigation, were observed. When excluding acute effects of recent alcohol intake, mild cognitive deficits but not morphological cerebral changes that are apparently due to long-term excessive social drinking were observed in males. In females there was no association between the drinking variables and cognitive deficits or morphological cerebral changes, probably due to their less advanced drinking habits. It is suggested that future risk evaluations and estimations of safe alcohol intake should take into consideration the potential risk for brain damage due to excessive social drinking. However, it is premature to make any definite statements about safe alcohol intake and the risk for brain damage in social drinkers from the general population.

Adult↗
PubMed1985

Effects of electroconvulsive therapy on neuropsychological function and circulating levels of ACTH, cortisol, prolactin, and TSH in patients with major depressive illness.

Thirteen patients with major depressive illness received unilateral electroconvulsive therapy (ECT). Memory and some other neuropsychological functions were studied concomitantly with changes in clinical symptoms. ACTH in plasma and cortisol, prolactin (PRL) and TSH in serum were measured 30 min before and 1, 5, 15, 30 and 60 min after treatment. Memory functions, impaired after the ECT series, were completely regained 1 month later. ACTH, cortisol, PRL and TSH were significantly increased by ECT. The maximum hormone level after ECT was lower at the last ECT in the series as compared with the first. After the last treatment, nonverbal memory performance was negatively associated with the maximum ACTH level after ECT and verbal learning was negatively correlated to the maximum cortisol level. The reason for these relationships is not known. Since both the ACTH secretion and memory function may be dependent upon the intracerebral catecholamines, the present findings may reflect variations in central monoaminergic receptor function.

Adolescent↗
PubMed1985

Severity of alcohol problems at follow-up--an outcome measure.

An ordinal scale to measure severity of alcohol problems in a follow-up study was constructed. The measure refers to the preceding 6 months and is based on reports of amount of alcohol consumed, drinking pattern, signs of alcohol dependence and time sober. The measure was tested on 300 patients reinvestigated about 2 1/2 years after discharge for inpatient treatment for alcoholism. Thirteen percent of the patients had no alcohol problems and 22% had severe alcohol problems. Rather more than one quarter of the group (27%) were classified as positive intermediates and 38% as negative intermediates. These results were compared with other data and information obtained from official records. It was concluded that the measure had satisfactory validity.

Adult↗