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Biomedical subjects

H Berger

Publications and source records attributed to H Berger.

At least 127 records · Page 7Linked to original sources
PubMed1994

[Radiological diagnosis in lung transplant patients].

Based on the imaging studies obtained from 13 patients after lung transplantation, radiological findings have been correlated with the clinical charts. The intention was to describe the radiological manifestations of the particular transplant complications of these patients. 12 episodes of reimplantation response were seen in the early postoperative period as a perihilar accented perivasal consolidation with typically short-termed appearances. 16 episodes of acute rejection showed various manifestations on the radiographs. They were characterised by immediate response to a bolus therapy with corticosteroids. This decisive observation allows the exclusion of other causes contributing to a condition following thoracotomy with similar radiological manifestations. Stenoses of the pulmonary or the bronchial anastomoses occurred once each and were confirmed in the course of further examinations. Chest radiograph proved to be the appropriate tool for the diagnosis of technical complications following iatrogenic measures (pleural effusion, pneumothorax). Clinical symptoms and follow-up observations are necessary for the interpretation of the radiographs. Chest radiography represents an important help concerning problems in differential diagnosis and further therapeutic decisions.

Acute Disease↗
PubMed1994

Intralesional interferon alpha-2b therapy for Buschke-Loewenstein tumour.

A patient with a Buschke-Loewenstein tumour associated with human papillomavirus type 6/11 is reported. He was intralesionally treated with human recombinant alpha-2b interferon (9 x 10(6) IU/day) three times weekly. The tumour completely disappeared within 5 months of continuous treatment which was well tolerated. Sixteen months after completion of therapy the patient remains well and free of disease.

Adult↗
PubMed1994

[Depression in independently living elderly, a study with the Zung-12].

The psychometric properties of the Zung-12, a short rating scale for the measurement of depression, were studied in a random sample (N = 79) taken from an elderly population living in their own homes in a medium sized town. Both internal and test-retest reliability of the Zung-12 are satisfactory. According to factor analyses the rating scale has a unidimensional structure. High correlations with the Befindlichkeitsskala and the SSWO support the convergent validity. No relation is found between depression score and age, amount of help received and household composition. Women and subjects with lower education appeared to have higher depression scores than respectively men and subjects with higher education. Administration of the Zung-12 in the morning produces higher depression scores than in the afternoon. 10% of the subjects score above the cutting point on one of the occasions, 4% on both occasions. Reliable change scores were calculated to indicate the statistical significance of differences between two administrations.

Aged↗
PubMed1993

Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene.

Polymerase chain reaction amplification of reverse transcribed RNA (RNA-PCR) was used to isolate overlapping cDNA clones encoding an inducible form of nitric oxide synthase (NOS) from purified rat hepatocytes. NOS gene expression in hepatocytes is dependent upon bacterial lipopolysaccharide (LPS) and cytokine treatment. The predicted amino acid sequence of rat hepatocyte inducible NOS is 94% identical with that from the mouse macrophage cell line, RAW264.7. Differences between the two sequences occur as sporadic amino acid substitutions with no major gaps or insertions. These differences are most likely the result of species variability which suggests that hepatocytes and macrophages express the same NOS gene upon induction.

Amino Acid Oxidoreductases↗
PubMed1993

Precocious puberty due to a lipid-cell tumour of the ovary.

A 4-year-old girl with a lipid cell tumour of the ovary showed isosexual precocious pseudopuberty. The endocrine activity of the tumour led to elevated plasma levels of dehydroepiandrosterone sulphate, oestradiol, testosterone and androstenedione. After tumour resection the clinical signs of abnormal hormonal stimulation disappeared within 10 months. The girl developed precocious puberty again 2 years later without any sign of relapse. Therapy with luteinizing hormone releasing hormone agonist was effective although premature activation of the hypothalamic-pituitary-gonadal axis could not clearly be demonstrated by hormonal investigations.

Buserelin↗
PubMed1993

Diabetes and its complications may be caused by inadequate circulation. A new concept.

Students of diabetes have noted that the so-called vascular complications of the disease appear with little or no consistency. Uncontrolled patients may have no vascular problems. Contrarywise obsessive compulsive individuals who follow every dietary regimen perfectly and take their prescriptions faithfully may have horrendous vascular difficulties. These experiences brought me to the conclusion that the 'complications' were really a component of the disease rather than the result of it. In an effort to find a unified concept of the disease it seemed reasonable to conclude that inadequate circulation to the islets may be a cause of the chemical constellation that we call diabetes. Vascular pathology may appear haphazardly in various arteries. Thus some will develop cerebrovascular disease, others coronary manifestations while still other patients will experience peripheral vascular symptoms. Is it not possible that defective circulation to the pancreas might be an aetiological factor in the development of diabetes? These observations lend credence to the concept that arterial pathology may actually precede the appearance of clinical diabetes.

Blood Glucose↗
PubMed1993

[The implantation of elastic metal endoprostheses in tracheal stenosis and tracheomalacia. The initial results with 4 patients].

Narrowing of the trachea due to tracheomalacia or compression can lead to life-threatening asphyxia and may require tracheotomy with intubation or endoscopic introduction of a stent. The use of a self-expanding elastic metal prosthesis in 4 patients with airway obstruction has proved a satisfactory alternative to conventional plastic prostheses, both in the acute phase and over a long period of time. After 4 weeks total epithelium cover of the stent could be demonstrated; biopsies after 3 and 4 months showed differentiation into respiratory ciliated epithelium. Patient acceptance was excellent since there was no sensation of a foreign body, retention of secretions or cough. The physical properties of the wall stent made it a suitable mechanical replacement for an unstable or narrowed trachea during the period of observation.

Aged↗
PubMed1993

[The results of a long-term follow-up of patients with a percutaneous cholecystostomy].

19 out of 37 patients with percutaneous cholecystostomy were followed up for assessment of gallbladder function after percutaneous drainage. 17 out of 19 of the patients remained free from symptoms of gallbladder disease during a mean follow-up period of 25.8 months. Contractility of the gallbladder calculated by measurement of the sonographic diameter of the gallbladder with provocation tests was 62%. One patient was operated upon for choledocholithiasis three years after percutaneous cholecystostomy. Histology showed signs of chronic cholecystitis. It can be concluded that cholecystectomy is not routinely necessary after percutaneous cholecystostomy provided biliary excretion is normal.

Acute Disease↗
PubMed1993

[Neurogenic intermittent claudication of the femoral nerve caused by occlusion of the common iliac artery].

A 52 year old heavy smoker complained of paresthesiae and pain at the ventral side of the right thigh and the antero-medial side of the right lower leg as well as weakness of the right quadriceps femoris during exercise. Clinical examination revealed a paresis of the right quadriceps, hypesthesia and hypalgesia in the area of the femoral nerve and a reduced right patellar reflex after 10 min walking. An occlusion of the right common iliac artery was diagnosed by angiography. Following transluminal angioplasty and implantation of an intravascular stent, the patient was free of symptoms. On the basis of the clinical observations following recanalisation of the common iliac artery, the symptoms can best be explained by a reduced perfusion of the iliolumbar artery supplying the upper part of the femoral nerve, causing ischemia of the femoral nerve during exercise. In conclusion, stenosis/occlusion of the common iliac artery should be considered as a differential diagnosis of quadriceps weakness and paresthesia in the area of the femoral nerve associated with exercise.

Angiography, Digital Subtraction↗
PubMed1993

[Expandable metal mesh stents for treatment of tracheal stenoses and tracheomalacia].

The treatment of tracheo-bronchial stenosis or tracheomalacia is mainly carried out by means of resection or tracheoplastic operative strategies. Since the introduction of metal-mesh stents, a definitive endoluminal therapy has to be considered under new aspects. Six patients with malignant stenosis or tracheomalacia due to compression were treated by implantation of Palmaz- or Wallstents. Immediately after the implantation, patients were relieved from dyspnoea, the forced inspiratory volume-1 (FIV1) was normalized. All implanted stents were well tolerated, even in the long-time follow-up (19 months). Bronchoscopic control showed overgrowth of the metal meshes by respiratory epithelium. The implantation of metal-mesh stents is an adequate alternative in the treatment of malignant stenosis and tracheomalacia.

Aged↗